Abstract: The present disclosure relates to heart valve prostheses, delivery devices, actuation handles, and other improved devices and methods that facilitate delivery of a heart valve prosthesis to a defective native valve structure in a patient, such as the aortic valve.

Abstract: The present disclosure relates to heart valve prostheses, delivery devices, actuation handles, and other improved devices and methods that facilitate delivery of a heart valve prosthesis to a defective native valve structure in a patient, such as the aortic valve.

Abstract: The present disclosure relates to heart valve prostheses, delivery devices, actuation handles, and other improved devices and methods that facilitate delivery of a heart valve prosthesis to a defective native valve structure in a patient, such as the aortic valve.

Abstract: A valve prosthesis and a system for delivering a valve prosthesis are described herein. The system can include a core member and an engagement mechanism for releasably engaging a radially expandable valve anchor of the valve prosthesis along the core member. The engagement mechanism can include a pin assembly slidably coupled to the core member and a nose cone including a lock component slidably coupled along the core member to permit the valve anchor to disengage from the pin assembly.

Abstract: The present disclosure relates to heart valve prostheses, delivery devices, actuation handles, and other improved devices and methods that facilitate delivery of a heart valve prosthesis to a defective native valve structure in a patient, such as the aortic valve.

Abstract: The present disclosure relates to heart valve prostheses, delivery devices, actuation handles, and other improved devices and methods that facilitate delivery of a heart valve prosthesis to a defective native valve structure in a patient, such as the aortic valve.

Abstract: A valve prosthesis and a system for delivering a valve prosthesis are described herein. The valve prosthesis can include a valve anchor having a longitudinal axis and proximal and distal end portions. The valve anchor can include a plurality of U-shaped members and a plurality of anchoring legs, each of the plurality of anchoring legs comprising a connection aperture at a distal end portion thereof and a longitudinal slot extending along a length of the anchoring leg, wherein the plurality of anchoring legs and the plurality of U-shaped members can radially expand in stages to permit a native valve structure to be interposed therebetween for anchoring the valve prosthesis relative to the native valve structure.

Abstract: A valve prosthesis and a system for delivering a valve prosthesis are described herein. The system can include a support frame, a valve anchor comprising an anchoring leg and a plurality of U-shaped members, and a suture coupled to the support frame and slidably coupled to the anchoring leg.

Abstract: This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.

Abstract: An integrated circuit for controlling operation of a motor of a fan assembly. The fan assembly includes a housing and a fan. The motor is in the housing. The housing is void of sensors. The motor is configured to rotate the fan. The integrated circuit includes a detection module and a first control module. The detection module is separate from the fan assembly. The detection module is configured to detect a voltage induced in a first coil of the motor or a back electromotive force received from the first coil of the motor. The first control module is configured to receive a control signal from a second control module and control the operation of the fan based on (a) the control signal, and (b) the voltage induced in the first coil of the motor or the back electromotive force. The second control module is separate from the integrated circuit.

Abstract: This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.

Abstract: This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.

Abstract: Compositions that inhibit or block the interaction between Erbin and ErbB2 and methods of their use are provided. Preferred compositions include peptides that inhibit or block Erbin and ErbB2 interaction under physiologic conditions in a subject. One embodiment provides an isolated peptide fragment of ErbB2 including the C-terminal 15 amino acids of ErbB2. The peptide fragment can be about 15 to 27 amino acids in length.

Abstract: This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.

Abstract: A system including memory to store a plurality of sets of values, where each set is used to control speed of a different type of motor. A pulse width modulation (PWM) module receives an input indicating a type of motor sensed in the system, selects a set corresponding to the type of the sensed motor, and generates, based on the selected set, a pulse width modulation signal to control speed of the sensed motor. A speed module receives a requested speed for the sensed motor and generates an output indicating a range of speed corresponding to the requested speed. The PWM module selects, based on the range of speed, a value from the selected set; shifts, based on the selected value, the pulse width modulation signal; and adjusts, based on the shifted pulse width modulation signal, the speed of the sensed motor by adjusting torque applied to the sensed motor.

Abstract: This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.

Abstract: This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.

Abstract: An integrated circuit for controlling operation of a motor of a fan assembly. The fan assembly includes a housing and a fan. The motor is in the housing. The housing is void of sensors. The motor is configured to rotate the fan. The integrated circuit includes a detection module and a first control module. The detection module is separate from the fan assembly. The detection module is configured to detect a voltage induced in a first coil of the motor or a back electromotive force received from the first coil of the motor. The first control module is configured to receive a control signal from a second control module and control the operation of the fan based on (a) the control signal, and (b) the voltage induced in the first coil of the motor or the back electromotive force. The second control module is separate from the integrated circuit.

Abstract: Disclosed are methods for treating hepatitis C in a human patient in need thereof that entails administering to the patient of about 350 mg of sofosbuvir and another anti-HCV compound.

Abstract: A system including memory to store a plurality of sets of values, where each set is used to control speed of a different type of motor. A pulse width modulation (PWM) module receives an input indicating a type of motor sensed in the system, selects a set corresponding to the type of the sensed motor, and generates, based on the selected set, a pulse width modulation signal to control speed of the sensed motor. A speed module receives a requested speed for the sensed motor and generates an output indicating a range of speed corresponding to the requested speed. The PWM module selects, based on the range of speed, a value from the selected set; shifts, based on the selected value, the pulse width modulation signal; and adjusts, based on the shifted pulse width modulation signal, the speed of the sensed motor by adjusting torque applied to the sensed motor.