Patents by Inventor Chenghang Zong

Chenghang Zong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of whole transcriptome amplification
    Patent number: 11162134
    Abstract: Embodiments of the disclosure encompass highly sensitive and quantitative methods for single-cell sequencing of total RNA. In particular cases, methods utilize annealing of multiple primers to RNA, polytailing of single stranded DNA reverse transcribed therefrom, and utilization of bar codes in primers for amplification of amplicons produced from second strand synthesis.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: November 2, 2021
    Assignee: Baylor College of Medicine
    Inventor: Chenghang Zong
  • Methods of linearly amplifying whole genome of a single cell
    Patent number: 11047001
    Abstract: Embodiments of the disclosure encompass methods of amplifying nucleic acid from one or more cells. In particular embodiments, the nucleic acid is amplified as amplicons in a linear manner. Specific embodiments include the removal or effective destruction of nonlinearly produced amplicons.
    Type: Grant
    Filed: May 8, 2019
    Date of Patent: June 29, 2021
    Assignee: Baylor College of Medicine
    Inventors: Chenghang Zong, Michael Gundry, Kuanwei Sheng
  • METHODS OF WHOLE TRANSCRIPTOME AMPLIFICATION
    Publication number: 20200299759
    Abstract: Embodiments of the disclosure encompass highly sensitive and quantitative methods for single-cell sequencing of total RNA. In particular cases, methods utilize annealing of multiple primers to RNA, polytailing of single stranded DNA reverse transcribed therefrom, and utilization of bar codes in primers for amplification of amplicons produced from second strand synthesis.
    Type: Application
    Filed: March 31, 2017
    Publication date: September 24, 2020
    Inventor: Chenghang Zong
  • METHODS OF LINEARLY AMPLIFYING WHOLE GENOME OF A SINGLE CELL
    Publication number: 20190264271
    Abstract: Embodiments of the disclosure encompass methods of amplifying nucleic acid from one or more cells. In particular embodiments, the nucleic acid is amplified as amplicons in a linear manner. Specific embodiments include the removal or effective destruction of nonlinearly produced amplicons.
    Type: Application
    Filed: May 8, 2019
    Publication date: August 29, 2019
    Inventors: Chenghang Zong, Michael Gundry, Kuanwei Sheng
  • Methods of linearly amplifying whole genome of a single cell
    Patent number: 10301671
    Abstract: Embodiments of the disclosure encompass methods of amplifying nucleic acid from one or more cells using MALBAC (multiple annealing and looping-based amplification cycles) primers. In particular embodiments, the nucleic acid is amplified as amplicons in a linear manner. Specific embodiments include the removal or effective destruction of nonlinearly produced amplicons.
    Type: Grant
    Filed: May 5, 2015
    Date of Patent: May 28, 2019
    Assignee: Baylor College of Medicine
    Inventors: Chenghang Zong, Michael Gundry, Kuanwei Sheng
  • METHODS OF LINEARLY AMPLIFYING WHOLE GENOME OF A SINGLE CELL
    Publication number: 20170183721
    Abstract: Embodiments of the disclosure encompass methods of amplifying nucleic acid from one or more cells using MALBAC (multiple annealing and looping-based amplification cycles) primers. In particular embodiments, the nucleic acid is amplified as amplicons in a linear manner. Specific embodiments include the removal or effective destruction of nonlinearly produced amplicons.
    Type: Application
    Filed: May 5, 2015
    Publication date: June 29, 2017
    Inventors: Chenghang Zong, Michael Gundry, Kuanwei Sheng
  • Methods of amplifying whole genome of a single cell
    Patent number: 9617598
    Abstract: Methods and compositions for amplifying the whole genome of a single cell are provided.
    Type: Grant
    Filed: May 22, 2012
    Date of Patent: April 11, 2017
    Assignee: President and Fellows of Harvard College
    Inventors: Xiaoliang Sunney Xie, Chenghang Zong, Sijia Lu
  • Methods of Amplifying Whole Genome of a Single Cell
    Publication number: 20140200146
    Abstract: Methods and compositions for amplifying the whole genome of a single cell are provided.
    Type: Application
    Filed: May 22, 2012
    Publication date: July 17, 2014
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Xiaoliang Sunney Xie, Chenghang Zong, Sijia Lu