Patents by Inventor Chengyun Yue
Chengyun Yue has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220054716Abstract: Provided is a bio-coating, including a surface layer. The surface layer includes multiple first single bodies connected in an unordered manner, multiple first through holes formed between the multiple first single bodies and inside the multiple first single bodies. The surface layer arranged on the outermost side of the bio-coating includes the multiple first single bodies connected in an unordered manner, and the multiple first through holes are formed between the multiple first single bodies and inside the multiple first single bodies, i.e., the multiple first single bodies in the surface layer are connected in an unordered manner. Therefore, the multiple first through holes in the surface layer are able to be in an unordered state, facilitating the growing of corresponding bone tissue cells into the surface layer, and thus improving a bone ingrowth effect and long-term stability.Type: ApplicationFiled: December 24, 2019Publication date: February 24, 2022Inventors: Chen XIN, Lingxiao LU, Xiaolong CHANG, Xiang LIU, Chengyun YUE
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Patent number: 9433709Abstract: An interventional medical device and manufacturing method thereof. The interventional medical device comprises: a stent body (1); a surface of the stent body (1) being provided with a drug releasing structure (3), and drug in the drug releasing structure (3) being drug for suppressing proliferation of adventitial fibroblasts and a drug for suppressing proliferation of intimal and/or smooth muscle cells. In use, after interventional medical device is implanted into a human body, the drug for suppressing proliferation of adventitial fibroblasts carried thereon can promote the compensatory expansion of the vessel, and the drug for suppressing proliferation of intimal cells and/or smooth muscle cells carried thereon can suppress intimal proliferation of the vessel. The combination of the two kinds of drugs greatly reduces the occurrence rate of in-stent restenosis.Type: GrantFiled: April 2, 2015Date of Patent: September 6, 2016Assignee: SHANGHAI MICROPORT MEDICAL (GROUP) CO., LTD.Inventors: Dadong Zhang, Xu Cai, Chengyun Yue, Junfei Li, Yan Hu, Peng Huang, Zhirong Tang, Qiyi Luo
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Patent number: 9226994Abstract: The present invention discloses an interventional medical device and methods of making the same. At least one coating layer is disposed on the outer surface of the interventional medical device and the material of the outmost layer of the coating layer is a sulfonate group-containing polymer. In the present invention, the material of the outmost layer of the interventional medical device is a sulfonate group-containing polymer. The polymer is endowed with a same surface property as that of heparin in addition to appropriate hydrophilicity due to the presence of the sulfonate group. After the interventional medical device is implanted into the human body, a hydrophilic surface is formed on the outer surface of the interventional medical device which is also negatively charged in the body fluid. Therefore, cells can easily adhere and grow on the outer surface thereof as a result of the enhanced cell compatibility.Type: GrantFiled: June 13, 2011Date of Patent: January 5, 2016Assignee: Shanghai MicroPort Medical (Group) Co., Ltd.Inventors: Junfei Li, Xi Hu, Chengyun Yue, Dawei Wang, Peng Huang, Zhirong Tang, Qiyi Luo, Zhaohua Chang
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Patent number: 9095431Abstract: An invasive cardiac valve comprises a tubular stent (1) and a valve (2). One end of the tubular stent (1) is of a frusto-conical structure, the other end is wide open, and the diameter of the open end is greater than the diameter of the frusto-conical end. The valve (2) is attached to the frusto-conical end of the tubular stent (1); and a delivery and retrieval hole (4) of the cardiac valve is provided at the top of the open end of the tubular stent (1). Because the diameter of the open end is greater than the diameter of the frusto-conical end, the cardiac valve can be effectively fixed in a position of aortic annulus to prevent the cardiac valve displacement caused by the impact of the blood flow. Because the valve (2) is attached to the frusto-conical end of the tubular stent (1), the valve (2) can totally avoid the left and right coronary ostia and does not affect the haemodynamics of the coronary artery.Type: GrantFiled: December 30, 2010Date of Patent: August 4, 2015Assignee: SHANGHAI MICROPORT MEDICAL (GROUP) CO., LTD.Inventors: Qifeng Yu, Xiang Liu, Yunlei Wang, Chengyun Yue, Qiyi Luo
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Publication number: 20150209485Abstract: An interventional medical device and manufacturing method thereof. The interventional medical device comprises: a stent body (1); a surface of the stent body (1) being provided with a drug releasing structure (3), and drug in the drug releasing structure (3) being drug for suppressing proliferation of adventitial fibroblasts and a drug for suppressing proliferation of intimal and/or smooth muscle cells. In use, after interventional medical device is implanted into a human body, the drug for suppressing proliferation of adventitial fibroblasts carried thereon can promote the compensatory expansion of the vessel, and the drug for suppressing proliferation of intimal cells and/or smooth muscle cells carried thereon can suppress intimal proliferation of the vessel. The combination of the two kinds of drugs greatly reduces the occurrence rate of in-stent restenosis.Type: ApplicationFiled: April 2, 2015Publication date: July 30, 2015Applicant: SHANGHAI MICROPORT MEDICAL (GROUP) CO., LTD.Inventors: Dadong ZHANG, Xu CAI, Chengyun YUE, Junfei LI, Yan HU, Peng HUANG, Zhirong TANG, Qiyi LUO
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Publication number: 20150004207Abstract: An interventional medical device and manufacturing method thereof, the interventional medical device comprising a stent body (1); the stent body (1) is provided with a drug releasing structure on the surface, the drug in the drug releasing structure being a drug for inhibiting adventitial fibroblast proliferation. When the interventional medical device is implanted into a human body, the drug for inhibiting the adventitial fibroblast proliferation can be slowly released into vessel wall cells in contact with the stent body (1), thus inhibiting the proliferation of the adventitial fibroblasts, promoting vascular compensatory expansion, and reducing the incidence rate of instent restenosis.Type: ApplicationFiled: January 17, 2012Publication date: January 1, 2015Applicant: SHANGHAI MICROPORT MEDICAL (GROUP) CO., LTD.Inventors: Xu Cai, Dadong Zhang, Yan Hu, Peng Huang, Junfei Li, Chengyun Yue, Zhirong Tang, Qiyi Luo
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Publication number: 20140248327Abstract: An interventional medical device and manufacturing method thereof. The interventional medical device comprises: a stent body (1); a surface of the stent body (1) being provided with a drug releasing structure (3), and drug in the drug releasing structure (3) being drug for suppressing proliferation of adventitial fibroblasts and a drug for suppressing proliferation of intimal and/or smooth muscle cells. In use, after interventional medical device is implanted into a human body, the drug for suppressing proliferation of adventitial fibroblasts carried thereon can promote the compensatory expansion of the vessel, and the drug for suppressing proliferation of intimal cells and/or smooth muscle cells carried thereon can suppress intimal proliferation of the vessel. The combination of the two kinds of drugs greatly reduces the occurrence rate of in-stent restenosis.Type: ApplicationFiled: January 16, 2012Publication date: September 4, 2014Applicant: SHANGHAI MICROPORT MEDICAL (GROUP) CO., LTD.Inventors: Dadong Zhang, Xu Cai, Chengyun Yue, Junfei Li, Yan Hu, Peng Huang, Zhirong Tang, Qiyi Luo
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Publication number: 20130296806Abstract: The present invention discloses an interventional medical device and methods of making the same. At least one coating layer is disposed on the outer surface of the interventional medical device and the material of the outmost layer of the coating layer is a sulfonate group-containing polymer. In the present invention, the material of the outmost layer of the interventional medical device is a sulfonate group-containing polymer. The polymer is endowed with a same surface property as that of heparin in addition to appropriate hydrophilicity due to the presence of the sulfonate group. After the interventional medical device is implanted into the human body, a hydrophilic surface is formed on the outer surface of the interventional medical device which is also negatively charged in the body fluid. Therefore, cells can easily adhere and grow on the outer surface thereof as a result of the enhanced cell compatibility.Type: ApplicationFiled: June 13, 2011Publication date: November 7, 2013Applicant: SHANGHAI MICROPORT MEDICAL (GROUP) CO LTDInventors: Junfei Li, Xi Hu, Chengyun Yue, Dawei Wang, Peng Huang, Zhirong Tang, Qiyi Luo, Zhaohua Chang
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Publication number: 20120316642Abstract: An invasive cardiac valve comprises a tubular stent (1) and a valve (2). One end of the tubular stent (1) is of a frusto-conical structure, the other end is wide open, and the diameter of the open end is greater than the diameter of the frusto-conical end. The valve (2) is attached to the frusto-conical end of the tubular stent (1); and a delivery and retrieval hole (4) of the cardiac valve is provided at the top of the open end of the tubular stent (1). Because the diameter of the open end is greater than the diameter of the frusto-conical end, the cardiac valve can be effectively fixed in a position of aortic annulus to prevent the cardiac valve displacement caused by the impact of the blood flow. Because the valve (2) is attached to the frusto-conical end of the tubular stent (1), the valve (2) can totally avoid the left and right coronary ostia and does not affect the haemodynamics of the coronary artery.Type: ApplicationFiled: December 30, 2010Publication date: December 13, 2012Applicant: MICROPORT MEDICAL (SHANGHAI) CO., LTDInventors: Qifeng Yu, Xiang Liu, Yunlei Wang, Chengyun Yue, Qiyi Luo
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Publication number: 20090004238Abstract: Methods of applying biocompatible coating materials around biological materials using photopolymerization while maintaining the pre-encapsulation status of the biological materials are disclosed. The coatings can be placed directly onto the surface of the biological materials or onto the surface of other coating materials that hold the biological materials. The components of the polymerization reactions that produce the coatings can include natural and synthetic polymers, macromers, accelerants, cocatalysts, photoinitiators, and radiation. Methods of utilizing these encapsulated biological materials to treat different human and animal diseases or disorders by implanting them into several areas in the body including the subcutaneous site are also disclosed.Type: ApplicationFiled: August 22, 2008Publication date: January 1, 2009Applicant: Novocell, Inc.Inventors: David Scharp, Paul Latta, Chengyun Yue, Xiaojie Yu, Jeffrey Alan Hubbell
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Patent number: 7427415Abstract: The present invention relates to compositions and methods of treating a disease, such as diabetes, by implanting encapsulated biological material into a patient in need of treatment. This invention provides for the placement of biocompatible coating materials around biological materials using photopolymerization while maintaining the pre-encapsulation status of the biological materials. Several methods are presented to accomplish coating several different types of biological materials. The coatings can be placed directly onto the surface of the biological materials or onto the surface of other coating materials that hold the biological materials. The components of the polymerization reactions that produce the coatings can include natural and synthetic polymers, macromers, accelerants, cocatalysts, photoinitiators, and radiation.Type: GrantFiled: October 14, 2003Date of Patent: September 23, 2008Assignee: Novocell, Inc.Inventors: David Scharp, Paul Latta, Chengyun Yue, Xiaojie Yu, Jeffrey Alan Hubbell
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Publication number: 20040136971Abstract: The present invention relates to compositions and methods of treating a disease, such as diabetes, by implanting encapsulated biological material into a patient in need of treatment. This invention provides for the placement of biocompatible coating materials around biological materials using photopolymerization while maintaining the pre-encapsulation status of the biological materials. Several methods are presented to accomplish coating several different types of biological materials. The coatings can be placed directly onto the surface of the biological materials or onto the surface of other coating materials that hold the biological materials. The components of the polymerization reactions that produce the coatings can include natural and synthetic polymers, macromers, accelerants, cocatalysts, photoinitiators, and radiation.Type: ApplicationFiled: October 14, 2003Publication date: July 15, 2004Inventors: David Scharp, Paul Latta, Chengyun Yue, Xiaojie Yu, Jeffrey Alan Hubbell