Abstract: The present invention provides a preparation method of a material for a puncture-resistant artificial blood vessel. The artificial blood vessel prepared by the method comprises two layers: the dense outer layer and the electrospun inner layer, the structures of these two layers are combined tightly and are inseparable, so that the properties of blood oozing resistance and repeated puncture resistance required by the artificial blood vessel can be provided. The puncture-resistant artificial blood vessel provided by the present invention has excellent biocompatibility, blood compatibility and flexibility and has the functions of blood oozing resistance and repeated puncture resistance. The method provided by the present invention has the characteristics such as convenience in operation, simplicity in production process and liability to the realization of large scale.

Abstract: The present invention provides a preparation method preparation method for three-layer artificial blood vessel and application thereof. The three-layer artificial blood vessel comprise three layers, electrospinning inner layer, dense middle layer and electrospinning outer layer, the three-layer structure is closely combined and difficult to separate. The inner layer with a cytoskeleton-like structure can promote the formation of intima; the dense middle layer can effectively prevent the leakage of biomacromolecules and increase the puncture resistance of the whole artificial blood vessel; and the outer layer can promote the growth of tissue cells and better integrate with tissue. The three-layer artificial blood vessel provided by the invention has excellent blood compatibility, good flexibility, good puncture resistance and interlayer peeling resistance. The preparation method is convenient and is suitable for industrial scale production.

Abstract: Disclosed are an injectable sustained-release pharmaceutical formulation and a process for preparing the same. In some embodiments, the formulation comprises an active ingredient in a therapeutically effective amount, an amphipathic molecule, an organic acid and/or a salt thereof which is hardly soluble in water, and an oily solvent. The injectable sustained-release pharmaceutical formulation provides a good sustained-release effect for various active ingredients, in particular peptides, proteins, nucleic acids and saccharides.