Abstract: A medical device adapted for implantation into a patient receives electrical power from an extracorporeal power supply. The medical device has a first receiver for a first wireless signal, a power circuit that extracts energy from the first wireless signal to power the medical device, and a feedback signal generator that transmits a second wireless signal indicating a magnitude of energy extracted from the first wireless signal. The extracorporeal power supply includes a source of electrical power and a power transmitter that emits the first wireless signal. A second receiver enables the extracorporeal power supply to receive the second wireless signal. A feedback controller manipulates the first wireless signal in response to the second wireless signal to ensure that sufficient electrical energy is provided to the medical device without wasting electrical power from the source.

Abstract: A medical device, such as a cardiac pacing device for an animal, includes an intravascular antenna that has a first coil for engaging a wall of a first blood vessel to receive a radio frequency signal. The first coil includes a first winding wound helically in a rotational direction along a longitudinal axis from a first end of the coil to a second end. A second winding that is connected to the a first winding at the second end, is wound helically in the same rotational direction along the longitudinal axis from the second end to the first end. An electronic circuit is implanted in the animal and is connected to the antenna to receive an electrical signal therefrom.

Abstract: A Class-E power amplifier includes a choke and a switch connected in series between a source of a supply voltage and circuit ground and connected to an inductively coupled coil. An output node of the amplifier is formed between choke and the switch and connected to a transmitter antenna. A shunt capacitor couples the amplifier's output node to the circuit ground. A feedback signal, indicating an intensity if the signal at the amplifier output node is used to vary the input signal to the Class-E power amplifier and thereby control operation of the switch.

Abstract: An abnormally rapid ventricular cardiac rate that results from atrial fibrillation can be reduced by stimulating a vagal nerve of the heart. An apparatus for such stimulation includes a power transmitter that emits a radio frequency signal. A stimulator, implanted in a blood vessel adjacent the vagal nerve, has a pair of electrodes and an electrical circuit thereon. The electrical circuit receives the radio frequency signal and derives an electrical voltage from the energy of that signal. The electrical voltage is applied in the form of pulses to the pair of electrodes, thereby stimulating the vagal nerve. The pattern of that stimulating pulses can be varied in response to characteristics of the atrial fibrillation or the ventricular contractions.

Abstract: An implantable vagal stimulation device with high-energy efficiency and novel data sensing is provided for use in a wide variety of applications where neural stimulation is required, including human heart rate control. The stimulation device uses low-impedance circuitry and digital waveforms to minimize energy losses, thereby requiring a relatively small battery. Front-loaded, passive filtering is employed to reduce electromagnetic noise sensitivity, leaving a clear physiological signal without degradations. This physiological signal is processed by a derivative zero transition detector (DZD), which is immune to variations in input signal dynamic range unlike traditional methods. Information that the DZD receives can be then interpreted and used along with an algorithm to execute appropriate vagal nerve stimulation.

Abstract: An implantable device provides artificial electrical stimulation of animal tissue using a plurality of electrodes. A sensing unit detects a physiological parameter at a stimulation site. A control unit governs the stimulation, in response to the detected physiological parameter, by selecting certain pairs of the electrodes and by defining the shape, duration, and duty cycle of a segmented stimulation waveform. A stimulation signal generator produces the segmented stimulation waveform that has a first segment and a second segment that with respect to the first segment is longer in duration lesser in magnitude and opposite in polarity.

Abstract: One or more techniques are provided for identifying a period of minimal motion for an organ of interest, such as the heart or lungs. Motion data is acquired for the organ of interest and for one or more proximate organs using sensor-based and/or image-based techniques. The sensor-based techniques may include electrical and non-electrical techniques. The image-based techniques may include both pre-acquisition and acquisition image data. The motion data for the organ of interest and proximate organs may be used to generate a set of multi-input motion data that may be processed to identify desired periods, such as periods of minimal motion, within the overall motion of the organ of interest.

Abstract: A Class-E amplifier has been adapted for use in the radio frequency section that drives a transmit coil of a magnetic resonance imaging (MRI) system. The Class-E amplifier responds to a radio frequency carrier signal and a control signal by producing a radio frequency excitation signal for driving the transmit coil. The Class-E amplifier includes a pickup coil that senses a signal emitted from the transmit coil and produces a feedback signal that is used to alter the control signal and thereby control production of the radio frequency excitation signal.

Abstract: An apparatus for sensing biological signals from an animal. The implanted apparatus includes at least one implantable electrode pair that is connected to a twisted pair of insulated conductors. The electrode pair is disposed at a first set of locations to sense biological signals. The twisted pair of insulated conductors is connected to an instrumentation amplifier via a passive network of filters. The amplifier amplifies the filtered biological signal from the electrode pair to provide an amplified differential signal. The amplifier has an internal voltage reference. Additionally, an energy source powers the apparatus without being connected to mains or an isolation transformer of medical equipment. A signal analysis module analyzes amplified differential signals to obtain at least one physiological parameter. The apparatus may also comprise a signal presentation module to display amplified signals and physiological parameters associated with the signal.

Abstract: A method and system of gating for a medical imaging system includes utilizing a non-electrical sensor to acquire information for gating. A sensor assembly usable in the method and system of gating may include a non-electrical sensor coupled to one side of a patient-sensor interface, the other side adapted for securing to a patient.

Abstract: A Class-E amplifier has been adapted for use in the radio frequency section of a magnetic resonance imaging (MRI) system. A drive signal is produced by modulating the envelope of a radio frequency carrier signal and then is applied to a switch in the Class-E amplifier. The switch is connected in series with a choke between a supply voltage terminal and circuit ground with an output node formed between the choke and the switch. The output node is coupled to circuit ground by a shunt capacitor. In a preferred embodiment, a pair of such amplifiers, that are ? radians out of phase, are connected to each rung of a transverse electromagnetic transmit array type radio frequency coil of the MRI system.

Abstract: One or more techniques are provided for identifying a period of minimal motion for an organ of interest, such as the heart or lungs. Motion data is acquired for the organ of interest and for one or more proximate organs using sensor-based and/or image-based techniques. The sensor-based techniques may include electrical and non-electrical techniques. The image-based techniques may include both pre-acquisition and acquisition image data. The motion data for the organ of interest and proximate organs may be used to generate a set of multi-input motion data that may be processed to identify desired periods, such as periods of minimal motion, within the overall motion of the organ of interest.

Abstract: A medical device adapted for implantation into a patient receives electrical power from an extravascular power supply. The medical device has a first receiver for a first radio frequency (RF) signal from which energy is extracted to power the medical device, and a second RF signal carries an indication of an amount of that extracted energy. The extravascular power supply includes a source of electrical power and a power transmitter that emits the first RF signal which is varied in response to the indication from the second radio frequency signal. Animal physiological data also can be carried by the second RF signal. The medical device includes a system that monitors the effects of tissue stimulation and regulates subsequent stimulation accordingly.

Abstract: A medical device adapted for implantation into a patient receives electrical power from an extravascular power supply. The medical device has a first receiver for a first radio frequency (RF) signal from which energy is extracted to power the medical device, and a second RF signal carries an indication of an amount of that extracted energy. The extravascular power supply includes a source of electrical power and a power transmitter that emits the first RF signal which is varied in response to the indication from the second radio frequency signal. Animal physiological data also can be carried by the second RF signal. The medical device includes a system that monitors the effects of tissue stimulation and regulates subsequent stimulation accordingly.

Abstract: An antenna module, that is compatible with a magnetic resonance imaging scanner for the purpose of diagnostic quality imaging, is adapted to be implanted inside an animal. The antenna module comprises an electrically non-conducting, biocompatible, and electromagnetically transparent enclosure with inductive antenna wires looping around an inside surface. An electronic module is enclosed in an electromagnetic shield inside the enclosure to minimize the electromagnetic interference from the magnetic resonance imaging scanner.

Abstract: A radio frequency antenna is provided for use with a medical device for implantation into an animal. The antenna comprises a coil formed by a wire that includes a core formed of a shape-memory material with an electrically conductive first layer applied to an outer surface of the core. A second layer, of an electrically insulating and biologically compatible material, extends around the first layer. If necessary to reduce friction, a lubricant is placed between the first and second layers. If second layer is formed of a porous material or a non-biological compatible material, a biological compatible outer layer surrounds the second layer thereby providing a barrier that is impermeable to body fluids of the animal.

Abstract: An intravascular implantable system for providing electrical stimulation of tissue inside an animal to deal with a clinical condition is described. The system comprises a power supply module supplying energy to the implantable system, an implanted control module controlling operation of the implantable system and producing desired digital waveforms. Each desired digital waveform has an envelope with a predetermined attribute. An implanted intravascular sensing module sensing at least one parameter of interest for the purpose of dealing with the clinical condition. An intravascular stimulation module is provided to electrically stimulate the tissue with an output waveform that is substantially similar to the desired digital waveform produced by the control module.

Abstract: An implantable biocompatible lead that is also compatible with a magnetic resonance imaging scanner for the purpose of diagnostic quality imaging is described. The implantable electrical lead comprises a plurality of coiled insulated conducting wires wound in a first direction forming a first structure of an outer layer of conductors of a first total length with a first number of turns per unit length and a plurality of coiled insulated conducting wires wound in a second direction forming a second structure of an inner layer of conductors of a second total length with a second number of turns per unit length. The first and the second structures are separated by a distance with a layer of dielectric material. The distance and dielectric material are chosen based on the field strength of the MRI scanner.

Abstract: An implantable device electrically stimulates an organ of an animal in response to a trigger event. Between trigger event that device receives a wireless signal, such as a radio frequency signal, and stores energy from the signal in a plurality of capacitors. The capacitors are located within a electrical lead that extends to a stimulation electrode attached to the organ. That electrical lead has a hollow outer insulating tube with a pair of conductors extending longitudinally therein. The plurality of capacitors are connected between the pair of conductors. Thus the electrical lead serves as both a conductor of a stimulation current to the electrode and a housing for the plurality of capacitors.

Abstract: An apparatus configured to detect transitions between relatively rising and falling amplitudes of an input signal Vin(t) arriving at a input node comprises a comparator having a first input, a second input, and an output for providing a two state output signal Vout(t) wherein state changes in the output signal Vout(t) correspond to the relatively rising amplitude of the input signal Vin(t) and the relatively falling amplitude of the input signal Vin(t). A delay circuit provides a shifted signal Vin(t+?t) to the second input of the comparator, and a hysteresis circuit provides hysteretic deadband appended input signal Vin+?V to the first input of the comparator.