Patents by Inventor Cheryl Davey

Cheryl Davey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid amplification process
    Patent number: 6063603
    Abstract: This invention relates to a process for amplifying a specific nucleic acid sequence. The process involves synthesizing single-stranded RNA, single-stranded DNA and double-stranded DNA. The single-stranded RNA is a first template for a first primer, the single-stranded DNA is a second template for a second primer, and the double stranded DNA is a third template for synthesis of a plurality of copies of the first template. A sequence of the first primer or the second primer is complementary to a sequence of the specific nucleic acid and a sequence of the first primer or the second primer is homologous to a sequence of the specific nucleic acid. The amplification process may be used to increase the quantity of the specific nucleic acid sequence to allow detection, or to increase the purity of the specific nucleic acid sequence as a substitute for conventional cloning methodology.
    Type: Grant
    Filed: February 26, 1996
    Date of Patent: May 16, 2000
    Assignee: Akzo Nobel N.V.
    Inventors: Cheryl Davey, Lawrence T. Malek
  • Nucleic acid amplification process
    Patent number: 5554517
    Abstract: This invention relates to a process for amplifying a specific nucleic acid sequence. The process involves synthesizing single-stranded RNA, single-stranded DNA and double-stranded DNA. The single-stranded RNA is a first template for a first primer, the single-stranded DNA is a second template for a second primer, and the double stranded DNA is a third template for synthesis of a plurality of copies of the first template. A sequence of the first primer or the second primer is complementary to a sequence of the specific nucleic acid and a sequence of the first primer or the second primer is homologous to a sequence of the specific nucleic acid. The amplification process may be used to increase the quantity of the specific nucleic acid sequence to allow detection, or to increase the purity of the specific nucleic acid sequence as a substitute for conventional cloning methodology.
    Type: Grant
    Filed: February 10, 1995
    Date of Patent: September 10, 1996
    Assignee: Akzo Nobel N.V.
    Inventors: Cheryl Davey, Lawrence T. Malek
  • Method for the synthesis of ribonucleic acid (RNA)
    Patent number: 5466586
    Abstract: The invention relates to a method for the synthesis of ribonucleic acid (RNA) starting from deoxyribonucleic acid (DNA). In the method of the invention, a double stranded DNA molecule is cleaved with a restriction endonuclease so as to generate a free 3'-end. The resultant DNA molecule is then denatured and hybridized with a primer that anneals to the 3'-end of the denatured DNA. The primer used in the hybridization contains a T7 promoter sequence at its 5'-end. Following the hybridization step, the 3'-ends of the resultant hybrid DNA molecule are extended with DNA polymerase to generate a template suitable for T7 RNA polymerase mediated RNA synthesis.
    Type: Grant
    Filed: February 7, 1994
    Date of Patent: November 14, 1995
    Assignee: Akzo Nobel N.V.
    Inventors: Cheryl Davey, Lawrence T. Malek, Peter F. Lens, Frits Wielaard
  • Nucleic acid amplification process
    Patent number: 5409818
    Abstract: This invention relates to a process for amplifying a specific nucleic acid sequence. The process involves synthesizing single-stranded RNA, single-stranded DNA and double-stranded DNA. The single-stranded RNA is a first template for a first primer, the single-stranded DNA is a second template for a second primer, and the double stranded DNA is a third template for synthesis of a plurality of copies of the first template. A sequence of the first primer or the second primer is complementary to a sequence of the specific nucleic acid and a sequence of the first primer or the second primer is homologous to a sequence of the specific nucleic acid. The amplification process may be used to increase the quantity of the specific nucleic acid sequence to allow detection, or to increase the purity of the specific nucleic acid sequence as a substitute for conventional cloning methodology.
    Type: Grant
    Filed: June 24, 1988
    Date of Patent: April 25, 1995
    Assignee: Cangene Corporation
    Inventors: Cheryl Davey, Lawrence T. Malek
  • Enhanced nucleic acid amplification process
    Patent number: 5130238
    Abstract: This invention relates to an improved process for amplifying a specific nucleic acid sequence. The process involves synthesizing single-stranded RNA, single-stranded DNA and Double-stranded DNA. The single-stranded RNA is a first template for a first primer, the single-stranded DNA is a second template for a second primer, and the double stranded DNA is a third template for synthesis of a plurality of copies of the first template. A sequence of the first primer or the second primer is complementary to a sequence of the specific nucleic acid and a sequence of the first primer or the second primer is homologous to a sequence of the specific nucleic acid. The improvement of the amplification process involves the addition of DMSO alone or in combination with BSA, which improves the specificity and efficiency of the amplification.
    Type: Grant
    Filed: August 23, 1989
    Date of Patent: July 14, 1992
    Assignee: Cangene Corporation
    Inventors: Lawrence T. Malek, Cheryl Davey, Graham Henderson, Roy Sooknanan