Patents by Inventor Cheryl I. Champion
Cheryl I. Champion has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9169303Abstract: Methods and compositions are provided herein for immunizing a subject by administering to the subject an effective amount of an immunogenic peptide or an immunogenic fragment or variant thereof incorporated within a vault-like particle carrier. The methods and compositions advantageously exhibit enhanced ability to induce cell-mediated immunity and/or antibody-based immunity.Type: GrantFiled: July 26, 2014Date of Patent: October 27, 2015Assignee: The Regents of the University of CaliforniaInventors: Valerie A. Kickhoefer, Leonard H. Rome, Kathleen A. Kelly, Cheryl I. Champion
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Publication number: 20140377301Abstract: Methods and compositions are provided herein for immunizing a subject by administering to the subject an effective amount of an immunogenic peptide or an immunogenic fragment or variant thereof incorporated within a vault-like particle carrier. The methods and compositions advantageously exhibit enhanced ability to induce cell-mediated immunity and/or antibody-based immunity.Type: ApplicationFiled: July 26, 2014Publication date: December 25, 2014Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Valerie A. Kickhoefer, Leonard H. Rome, Kathleen A. Kelly, Cheryl I. Champion
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Patent number: 8834896Abstract: Methods and compositions are provided herein for immunizing a subject by administering to the subject an effective amount of an immunogenic peptide or an immunogenic fragment or variant thereof incorporated within a vault-like particle carrier. The methods and compositions advantageously exhibit enhanced ability to induce cell-mediated immunity and/or antibody-based immunity.Type: GrantFiled: January 10, 2013Date of Patent: September 16, 2014Assignee: The Regents of the University of CaliforniaInventors: Valerie A. Kickhoefer, Leonard H. Rome, Kathleen A. Kelly, Cheryl I. Champion
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Publication number: 20130122037Abstract: Methods and compositions are provided herein for immunizing a subject by administering to the subject an effective amount of an immunogenic peptide or an immunogenic fragment or variant thereof incorporated within a vault-like particle carrier. The methods and compositions advantageously exhibit enhanced ability to induce cell-mediated immunity and/or antibody-based immunity.Type: ApplicationFiled: January 10, 2013Publication date: May 16, 2013Inventors: Valerie A. Kickhoefer, Leonard H. Rome, Kathleen A. Kelly, Cheryl I. Champion
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Publication number: 20130078273Abstract: Methods and compositions are provided herein for immunizing a subject by administering to the subject an effective amount of an immunogenic peptide or an immunogenic fragment or variant thereof incorporated within a vault-like particle carrier. The methods and compositions advantageously exhibit enhanced ability to induce cell-mediated immunity and/or antibody-based immunity.Type: ApplicationFiled: November 26, 2012Publication date: March 28, 2013Inventors: Valerie A. Kickhoefer, Leonard H. Rome, Kathleen A. Kelly, Cheryl I. Champion
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Patent number: 8318182Abstract: Methods and compositions are provided herein for immunizing a subject against Chlamydial genital infection by administering to the subject an effective amount of a Chlamydial immunogenic peptide or an immunogenic fragment or variant thereof incorporated within a vault-like particle carrier. In some aspects, the vault-like-particles are administered to the nasal mucosa. The methods and compositions advantageously exhibit enhanced ability to induce cell-mediated immunity and/or antibody-based immunity at mucosal surfaces while reducing inflammation associated with Chlamydia infection.Type: GrantFiled: February 10, 2012Date of Patent: November 27, 2012Assignee: The Regents of the University of CaliforniaInventors: Valerie A. Kickhoefer, Leonard H. Rome, Kathleen A. Kelly, Cheryl I. Champion
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Publication number: 20120141534Abstract: Methods and compositions are provided herein for immunizing a subject against Chlamydial genital infection by administering to the subject an effective amount of a Chlamydial immunogenic peptide or an immunogenic fragment or variant thereof incorporated within a vault-like particle carrier. In some aspects, the vault-like-particles are administered to the nasal mucosa. The methods and compositions advantageously exhibit enhanced ability to induce cell-mediated immunity and/or antibody-based immunity at mucosal surfaces while reducing inflammation associated with Chlamydia infection.Type: ApplicationFiled: February 10, 2012Publication date: June 7, 2012Inventors: Valerie A. Kickhoefer, Leonard H. Rome, Kathleen A. Kelly, Cheryl I. Champion
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Patent number: 8124109Abstract: Methods and compositions are provided herein for immunizing a subject against Chlamydial genital infection by administering to the subject an effective amount of a Chlamydial immunogenic peptide or an immunogenic fragment or variant thereof incorporated within a vault-like particle carrier. In some aspects, the vault-like-particles are administered to the nasal mucosa. The methods and compositions advantageously exhibit enhanced ability to induce cell-mediated immunity and/or antibody-based immunity at mucosal surfaces while reducing inflammation associated with Chlamydia infection.Type: GrantFiled: May 15, 2009Date of Patent: February 28, 2012Assignee: The Regents of the University of CaliforniaInventors: Valerie A. Kickhoefer, Leonard H. Rome, Kathleen A. Kelly, Cheryl I. Champion
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Publication number: 20090304751Abstract: Methods and compositions are provided herein for immunizing a subject against Chlamydial genital infection by administering to the subject an effective amount of a Chlamydial immunogenic peptide or an immunogenic fragment or variant thereof incorporated within a vault-like particle carrier. In some aspects, the vault-like-particles are administered to the nasal mucosa. The methods and compositions advantageously exhibit enhanced ability to induce cell-mediated immunity and/or antibody-based immunity at mucosal surfaces while reducing inflammation associated with Chlamydia infection.Type: ApplicationFiled: May 15, 2009Publication date: December 10, 2009Inventors: Valerie A. Kickhoefer, Leonard H. Rome, Kathleen A. Kelly, Cheryl I. Champion
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Patent number: 6685945Abstract: An antigenic preparation is provided which contains a 31 Kd outer membrane protein from Leptospira which can be used immunologically as a vaccine for leptospirosis caused by this organism.Type: GrantFiled: August 19, 1997Date of Patent: February 3, 2004Assignee: The Regents of the University of CaliforniaInventors: David A. Haake, David R. Blanco, Cheryl I. Champion, Michael A. Lovett, James N. Miller
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Patent number: 6677439Abstract: Antigenic rare outer membrane proteins of Spirochaetaceae are obtained from organisms extracted from infected tissue by a novel process of isolation utilizing a discontinuous Ficoll gradient separation, release of outer membrane in a low isotonic and low pH buffer and identification of outer membrane by use of a lipid soluble dye. Four antigenic rare outer membrane proteins of T. pallidum subsp. pallidum useful in diagnosis and prophylaxis of syphilis are provided. Also provided is the amino acid sequence of a rare outer membrane protein of T. pallidum subsp. pallidum and the nucleotide sequence encoding it.Type: GrantFiled: October 13, 1998Date of Patent: January 13, 2004Assignee: The Regents of the University of CaliforniaInventors: David R. Blanco, James N. Miller, Michael A. Lovett, Cheryl I. Champion
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Publication number: 20030162208Abstract: An antigenic preparation is provided which contains a 31 Kd outer membrane protein from Leptospira which can be used immunologically as a vaccine for leptospirosis caused by this organism.Type: ApplicationFiled: December 17, 2002Publication date: August 28, 2003Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, a California corporationInventors: David A. Haake, David R. Blanco, Cheryl I. Champion, Michael A. Lovett, James N. Miller
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Publication number: 20020071845Abstract: An antigenic preparation is provided which contains a 31 Kd outer membrane protein from Leptospira which can be used immunologically as a vaccine for leptospirosis caused by this organism.Type: ApplicationFiled: August 19, 1997Publication date: June 13, 2002Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: DAVID A. HAAKE, DAVID R. BLANCO, CHERYL I. CHAMPION, MICHAEL A. LOVETT, JAMES N. MILLER
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Patent number: 6153194Abstract: The present invention presents three B. burgdorferi membrane proteins: Oms28, Oms45, and Oms66, each of about 28, 45, and 66 kDa respectively; and with average single channel conductances of about 0.6, 0.22, and 9.7 nS, respectively. Also disclosed are the methods for purifying these proteins from B. burgdorferi, methods for producing antibodies to these proteins, and the resulting antibodies. These proteins and their immunogenic fragments, and antibodies capable of binding to them are useful for inducing an immune response to pathogenic B. burgdorferi as well as providing a diagnostic target for Lyme disease. Further disclosed are the nucleotide and amino acid sequences, the cloning of the genes encoding the proteins and their recombinant proteins, and methods for obtaining the foregoing. Other B. burgdorferi outer membrane spanning proteins (Oms) obtainable by the isolation and purification methods of the present invention.Type: GrantFiled: October 29, 1998Date of Patent: November 28, 2000Assignee: The Regents of the University of CaliforniaInventors: Jonathan T. Skare, Ellen S. Shang, Cheryl I. Champion, David R. Blanco, James N. Miller, Michael A. Lovett, Tajib A. Mirzabekov, Bruce L. Kagan, Paul Tempst, Denise M. Foley
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Patent number: 5854395Abstract: The present invention provides EppA polypeptide, a Borrelia burgdorferi virulence protein. This 17-kD outer membrane protein has been designated EppA for exported plasmid protein A.Type: GrantFiled: September 24, 1996Date of Patent: December 29, 1998Assignee: The Regents of the University of CaliforniaInventors: Cheryl I. Champion, Michael A. Lovett, David A. Haake, James N. Miller, David R. Blanco
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Patent number: 5821085Abstract: Antigenic rare outer membrane proteins of Spirochaetaceae are obtained from organisms extracted from infected tissue by a novel process of isolation utilizing a discontinuous Ficoll gradient separation, release of outer membrane in a low isotonic and low pH buffer and identification of outer membrane by use of a lipid soluble dye. Four antigenic rare outer membrane proteins of T. pallidum subsp. pallidum useful in diagnosis and prophylaxis of syphilis are provided. Also provided is the amino acid sequence of a rare outer membrane protein of T. pailidum subsp. pallidum and the nucleotide sequence encoding it.Type: GrantFiled: April 23, 1997Date of Patent: October 13, 1998Assignee: The Regents of the University of CaliforniaInventors: David R. Blanco, James N. Miller, Michael A. Lovett, Cheryl I. Champion
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Patent number: 5753459Abstract: Antigenic rare outer membrane proteins of Spirochaetaceae are obtained from organisms extracted from infected tissue by a novel process of isolation utilizing a discontinuous Ficoll gradient separation, release of outer membrane in a low isotonic and low pH buffer and identification of outer membrane by use of a lipid soluble dye. Four antigenic rare outer membrane proteins of T. pallidum subsp. pallidum useful in diagnosis and prophylaxis of syphilis are provided. Also provided are the amino acid sequences of two rare outer membrane proteins of T. pallidum subsp. pallidum, called TROMP 1 and TROMP 2, and the nucleotide sequences encoding them.Type: GrantFiled: January 23, 1996Date of Patent: May 19, 1998Assignees: The Regents of the University of California, Sloan-Kettering Institute for Cancer ResearchInventors: David R. Blanco, James N. Miller, Michael A. Lovett, Cheryl I. Champion, Paul J. Tempst
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Patent number: 5658757Abstract: An antigenic preparation is provided which contains a 31 Kd outer membrane protein from Leptospira which can be used immunologically as a vaccine for leptospirosis caused by this organism.Type: GrantFiled: December 20, 1994Date of Patent: August 19, 1997Assignee: The Regents of the University of CaliforniaInventors: David A. Haake, David R. Blanco, Cheryl I. Champion, Michael A. Lovett, James N. Miller
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Patent number: 5558993Abstract: A polynucleotide encoding a 17-kD virulence protein, called EppA, from Borrelia burgdorferi is provided. The protein encoded by the polynucleotide of the invention is useful immunologically as a vaccine for Lyme borreliosis caused by B. burgdorferi. Methods and kits for detection of EppA polynucleotide are also provided.Type: GrantFiled: June 17, 1994Date of Patent: September 24, 1996Assignee: The Regents of the University of CaliforniaInventors: Cheryl I. Champion, Michael A. Lovett, David A. Haake, James N. Miller, David R. Blanco