Abstract: Systems, apparatus and methods are provided for logical-to-physical (L2P) address translation. A method may comprise receiving a request for a first logical data address (LDA), and calculating a first translation data unit (TDU) index for a first TDU. The first TDU may contain a L2P entry for the first LDA. The method may further comprise searching a cache of lookup directory entries of recently accessed TDUs using the first TDU index, determining that there is a cache miss, generating and storing an outstanding request for the lookup directory entry for the first TDU in a miss buffer, retrieving the lookup directory entry for the first TDU from an in-memory lookup directory, determining that the lookup directory entry for the first TDU is not valid, reserve a TDU space for the first TDU in a memory and generating a load request for the first TDU.

Abstract: Systems, apparatus and methods are provided for logical-to-physical (L2P) address translation. A method may comprise receiving a request for a first logical data address (LDA), and calculating a first translation data unit (TDU) index for a first TDU. The first TDU may contain a L2P entry for the first LDA. The method may further comprise searching a cache of lookup directory entries of recently accessed TDUs using the first TDU index, determining that there is a cache miss, generating and storing an outstanding request for the lookup directory entry for the first TDU in a miss buffer, retrieving the lookup directory entry for the first TDU from an in-memory lookup directory, determining that the lookup directory entry for the first TDU is not valid, reserve a TDU space for the first TDU in a memory and generating a load request for the first TDU.

Abstract: Systems, apparatus and methods are provided for logical-to-physical (L2P) address translation. A method may comprise receiving a request for a first logical data address (LDA), and calculating a first translation data unit (TDU) index for a first TDU. The first TDU may contain a L2P entry for the first LDA. The method may further comprise searching a cache of lookup directory entries of recently accessed TDUs using the first TDU index, determining that there is a cache miss, generating and storing an outstanding request for the lookup directory entry for the first TDU in a miss buffer, retrieving the lookup directory entry for the first TDU from an in-memory lookup directory, determining that the lookup directory entry for the first TDU is not valid, reserve a TDU space for the first TDU in a memory and generating a load request for the first TDU.

Abstract: Systems, apparatus and methods are provided for logical-to-physical (L2P) address translation. A method may comprise receiving a request for a first logical data address (LDA), and calculating a first translation data unit (TDU) index for a first TDU. The first TDU may contain a L2P entry for the first LDA. The method may further comprise searching a cache of lookup directory entries of recently accessed TDUs using the first TDU index, determining that there is a cache miss, generating and storing an outstanding request for the lookup directory entry for the first TDU in a miss buffer, retrieving the lookup directory entry for the first TDU from an in-memory lookup directory, determining that the lookup directory entry for the first TDU is not valid, reserve a TDU space for the first TDU in a memory and generating a load request for the first TDU.

Abstract: The invention provides a liposome composition for delivering high pay-load of a therapeutic agent to neovascularization sites of the eyes in a patient in need thereof. The liposome composition for entrapping the therapeutic agent comprises a particle forming component composed of a variety of vesicle-forming lipids, and an agent-carrying component able to form a complex with the therapeutic agent via electrostatic charge-charge interaction or hydrophobic-hydrophobic interaction; wherein the liposome composition comprising the therapeutic agent has a mean particle diameter of about 30 to 200 nm and may accumulate at the neovascularization sites of the eyes 24 hours after the intravenous administration of the liposome composition comprising the therapeutic agent to the patient. A method for delivering the therapeutic agent to the eyes in a patient with this liposome composition is also provided.

Abstract: The invention provides a liposome composition for delivering high pay-load of a therapeutic agent to neovascularization sites of the eyes in a patient in need thereof. The liposome composition for entrapping the therapeutic agent comprises a particle forming component composed of a variety of vesicle-forming lipids, and an agent-carrying component able to form a complex with the therapeutic agent via electrostatic charge-charge interaction or hydrophobic-hydrophobic interaction; wherein the liposome composition comprising the therapeutic agent has a mean particle diameter of about 30 to 200 nm and may accumulate at the neovascularization sites of the eyes 24 hours after the intravenous administration of the liposome composition comprising the therapeutic agent to the patient.