Patents by Inventor Chi-nung W. Hsiao

Chi-nung W. Hsiao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of matrix metalloproteinase inhibitors
    Patent number: 6441189
    Abstract: The instant invention provides a process for the synthesis of matrix metalloproteinase inhibitors.
    Type: Grant
    Filed: December 13, 2001
    Date of Patent: August 27, 2002
    Assignee: Abbott Laboratories
    Inventors: Anne E. Bailey, David R. Hill, Chi-nung W. Hsiao, Ravi Kurukulasuriya, Steve Wittenberger, Todd McDermott, Maureen A. McLaughlin
  • Process for the preparation of matrix metalloproteinase inhibitors
    Publication number: 20020052511
    Abstract: The instant invention provides a process for the synthesis of matrix metalloproteinase inhibitors.
    Type: Application
    Filed: December 13, 2001
    Publication date: May 2, 2002
    Inventors: Anne E. Bailey, David R. Hill, Chi-Nung W. Hsiao, Ravi Kurukulasuriya, Steve Wittenberger, Todd McDermott, Maureen A. McLaughlin
  • Process for the preparation of matrix metalloproteinase inhibitors
    Publication number: 20020019539
    Abstract: The instant invention provides a process for the synthesis of matrix metalloproteinase inhibitors.
    Type: Application
    Filed: March 30, 2001
    Publication date: February 14, 2002
    Inventors: Anne E. Bailey, David R. Hill, Chi-Nung W. Hsiao, Ravi Kurukulasuriya, Steve Wittenberger, Todd McDermott, Maureen A. McLaughlin
  • Process for preparation of 4H-4-oxo-quinolizine-3-carboxylic acid
    Patent number: 5693813
    Abstract: A process for the preparation of a compound having the formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are defined, from an enamine by chain expansion and ring closure followed by additional derivatization, treatment with a 3-alkoxyl-acryloyl compound, another ring closure, and converting a hydroxyl group to a leaving group.
    Type: Grant
    Filed: February 26, 1997
    Date of Patent: December 2, 1997
    Assignee: Abbott Laboratories
    Inventors: Wei-Bo Wang, Francis A. J. Kerdesky, Chi-Nung W. Hsiao, Qun Li, Daniel T. Chu
  • Process for the preparation of a renin inhibiting compound
    Patent number: 5275950
    Abstract: Intermediates and a process for their preparation are disclosed which are useful for the preparation of a renin inhibiting compound of the formula: ##STR1## wherein R is a nitrogen-containing heterocycle which is bonded via a nitrogen atom to the sulfonyl group, R.sub.6 is hydrogen, alkoxy, halogen or loweralkyl, R.sub.7 is loweralkyl having 2 to 7 carbon atoms, and R.sub.8 is loweralkyl, cycloalkyl, or aryl or a pharmaceutically acceptable acid addition salt thereof.
    Type: Grant
    Filed: February 10, 1993
    Date of Patent: January 4, 1994
    Assignee: Abbott Laboratories
    Inventors: Daniel A. Dickman, Bruce W. Horrom, Chi-Nung W. Hsiao, M. Robert Leanna, Hormoz Mazdiyasni, Howard E. Morton, Thomas M. Zydowsky, William R. Baker, Stephen L. Condon
  • Dopamine agonists
    Patent number: 4963568
    Abstract: Novel compounds which are selective dopamine agonists are useful for treating disorders characterized by abnormal dopamine levels, such as Parkinson's Disease, as well as cardiovascular disorders.
    Type: Grant
    Filed: May 31, 1989
    Date of Patent: October 16, 1990
    Assignee: Abbott Laboratories
    Inventors: Robert W. Schoenleber, John W. Kebabian, Yvonne C. Martin, Michael P. DeNinno, Richard J. Perner, David M. Stout, Chi-Nung W. Hsiao, Stanley DiDomenico, Jr., John F. DeBernardis, Fatima Z. Basha, Michael D. Meyer, Biswanath De
  • Process for intermediates to 1-carbapenems and 1-carbacephems
    Patent number: 4845229
    Abstract: A stereoselective process for chiral intermediates to 1-carbapenem and 1-carbacephalosporins is provided comprising the use of an N-acyl-(4R)-substituted-1,3-thiazolidine-2-thione as a chiral auxiliary in boron enolate mediated aldol condensation with a protected-.beta.-keto ester aldehyde. E.g., benzyl 3,3-(ethylenedioxy)-4-formylbutyrate is condensed with the boron enolate formed with n-butyryl (4R)-methoxycarbonyl-1,3-thiazolidine-2-thione to provide benzyl 3,3-ethylenedioxy-(5R)-hydroxy-6-[(4R)-methoxycarbonyl-1,3-thiazolidine-2- thione-3-ylcarbonyl]octanoate. Displacement of the thiazolidine-2-thione chiral auxiliary moiety with an O-alkyl, O-acyl or O-aralkyl hydroxyamine provides the corresponding chiral intermediate as the hydroxamate.
    Type: Grant
    Filed: February 26, 1988
    Date of Patent: July 4, 1989
    Assignee: University of Notre Dame du Lac
    Inventors: Chi-nung W. Hsiao, Marvin J. Miller
  • Process for intermediates to 1-carbapenems and 1-carbacephems
    Patent number: 4745201
    Abstract: A stereoselective process for chiral intermediates to 1-carbapenum and 1-carbacephalosporins is provided comprising the use of an N-acyl-(4R)-substituted-1,3-thiazolidine-2-thione as a chiral auxiliary in boron enolate mediated aldol condensation with a protected-.beta.-keto ester aldehyde. E.g., benzyl 3,3-(ethylenedioxy)-4-formylbutyrate is condensed with the boron enolate formed with n-butyryl (4R)-methoxycarbonyl-1,3-thiazolidine-2-thione to provide benzyl 3,3-ethylenedioxy-(5R)-hydroxy-6-[(4R)-methoxycarbonyl-1,3-thiazolidine-2- thione-3-ylcarbonyl]octanoate. Displacement of the thiazolidine-2-thione chiral auxiliary moiety with an O-alkyl, O-acyl or O-aralkyl hydroxyamine provides the corresponding chiral intermediate as the hydroxamate.
    Type: Grant
    Filed: September 25, 1985
    Date of Patent: May 17, 1988
    Assignee: University of Notre Dame du Lac
    Inventors: Chi-nung W. Hsiao, Marvin J. Miller