Patents by Inventor Chia-Yi Kuan

Chia-Yi Kuan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160317473
    Abstract: This disclosure relates to managing brain injury. In certain embodiments, this disclosure relates to methods comprising administering an effective amount of an inhibitor of sphingosine-1-phoshate signaling, an inhibitor of retinoic-acid-receptor-related orphan receptors ? or ?, and/or an inhibitor of tPA microglial activation to a subject in need thereof. Typically, the subject is a neonate or a neonate born prematurely.
    Type: Application
    Filed: May 19, 2015
    Publication date: November 3, 2016
    Inventors: Chia-Yi Kuan, Dianer Yang, Yu-Yo Sun
  • Publication number: 20120240247
    Abstract: The c-Jun NH2-terminal kinase (JNK) group of MAP kinases are activated by exposure of cells to environmental stress. The role of JNK in the brain was examined by targeted disruption of the gene that encodes the neuronal isoform JNK3. It was found that JNK3 is required for the normal response to seizure activity. Methods of screening for molecules and compounds that decrease JNK3 expression or activity are described. Such molecules or compounds are useful for treating disorders involving excitotoxicity such as seizure disorders, Alzheimer's disease, Huntington disease, Parkinson's disease, and ischaemia.
    Type: Application
    Filed: December 16, 2011
    Publication date: September 20, 2012
    Inventors: Roger J. Davis, Richard A. Flavell, Pasko Rakic, Alan J. Whitmarsh, Chia-Yi Kuan, Derek Di Yang
  • Publication number: 20100286053
    Abstract: Plasminogen activators as potential therapeutic targets in neonatal hypoxia ischemia (HI) brain injury. Use of plasminogen activator inhibitor-1 (PAI-1) to ameliorate HI encephalopathy related disease. Use of PAI-1 as preventive treatment of cerebral palsy (CP).
    Type: Application
    Filed: May 6, 2010
    Publication date: November 11, 2010
    Applicants: Children's Hospital Medical Center, The Regents Of The University of Michigan
    Inventors: Chia-Yi Kuan, Daniel A. Lawrence, Dian Er Yang, Faisal Adhami
  • Patent number: 6943000
    Abstract: The c-Jun NH2-terminal kinase (JNK) group of MAP kinases are activated by exposure of cells to environmental stress. The role of JNK in the brain was examined by targeted disruption of the gene that encodes the neuronal isoform JNK3. It was found that JNK3 is required for the normal response to seizure activity. Methods of screening for molecules and compounds that decrease JNK3 expression or activity are described. Such molecules or compounds are useful for treating disorders involving excitotoxicity such as seizure disorders, Alzheimer's disease, Huntington disease, Parkinson's disease, and ischaemia.
    Type: Grant
    Filed: October 2, 1998
    Date of Patent: September 13, 2005
    Assignees: University of Massachusetts, Yale University
    Inventors: Roger J. Davis, Richard A. Flavell, Pasko Rakic, Alan J. Whitmarsh, Chia-Yi Kuan, Derek Di Yang
  • Publication number: 20030023990
    Abstract: The c-Jun NH2-terminal kinase (JNK) group of MAP kinases are activated by exposure of cells to environmental stress. The role of JNK in the brain was examined by targeted disruption of the gene that encodes the neuronal isoform JNK3. It was found that JNK3 is required for the normal response to seizure activity. Methods of screening for molecules and compounds that decrease JNK3 expression or activity are described. Such molecules or compounds are useful for treating disorders involving excitotoxicity such as seizure disorders, Alzheimer's disease, Huntington disease, Parkinson's disease, and ischaemia.
    Type: Application
    Filed: October 2, 1998
    Publication date: January 30, 2003
    Applicant: University of Massachusetts
    Inventors: ROGER J. DAVIS, RICHARD A. FLAVELL, PASKO RAKIC, ALAN J. WHITMARSH, CHIA-YI KUAN, DEREK DI YANG