Abstract: The T cells specific to human collagen type II, one of the possible autoantigens, have a crucial role in the development of rheumatoid arthritis in the context of HLA-DR4. The protein-protein interactions between the T cell receptor (TCR) and the type II collagen linked to the allele MHC of class II HLA-DR4 may thus represent the target for the development of new drugs against rheumatoid arthritis. Using computational virtual screening techniques, families of pharmacologically active molecules have been identified that interfere with the TCR/collagen II-MHCII interaction. The compounds identified here open up new possibilities in the treatment of rheumatoid arthritis.

Abstract: The T cells specific to human collagen type II, one of the possible autoantigens, have a crucial role in the development of rheumatoid arthritis in the context of HLA-DR4. The protein-protein interactions between the T cell receptor (TCR) and the type II collagen linked to the allele MHC of class II HLA-DR4 may thus represent the target for the development of new drugs against rheumatoid arthritis. Using computational virtual screening techniques, families of pharmacologically active molecules have been identified that interfere with the TCR/collagen II-MHCII interaction. The compounds identified here open up new possibilities in the treatment of rheumatoid arthritis.

Abstract: The T cells specific to human collagen type II, one of the possible autoantigens, have a crucial role in the development of rheumatoid arthritis in the context of HLA-DR4. The protein-protein interactions between the T cell receptor (TCR) and the type II collagen linked to the allele MHC of class II HLA-DR4 may thus represent the target for the development of new drugs against rheumatoid arthritis. Using computational virtual screening techniques, families of pharmacologically active molecules have been identified that interfere with the TCR/collagen ll-MHCII interaction. The compounds identified here open up new possibilities in the treatment of rheumatoid arthritis.

Abstract: The T cells specific to human collagen type II, one of the possible autoantigens, have a crucial role in the development of rheumatoid arthritis in the context of HLA-DR4. The protein-protein interactions between the T cell receptor (TCR) and the type II collagen linked to the allele MHC of class II HLA-DR4 may thus represent the target for the development of new drugs against rheumatoid arthritis. Using computational virtual screening techniques, families of pharmacologically active molecules have been identified that interfere with the TCR/collagen ll-MHCII interaction. The compounds identified here open up new possibilities in the treatment of rheumatoid arthritis.

Abstract: A device and related method for producing electrical energy, in the form of current flowing in a load. The said method uses two solutions with different ionic concentration as energy source. The said device includes at least two electrodes immersed at least partially in a liquid contained in a cell. The method includes a plurality of phases. Among them, a phase in which the electrodes and are brought into contact with a first solution; a phase in which they are electrically charged; a phase in which they are brought into contact with a second solution; a phase in which at least a part of the accumulated charge is let flow through the load. The energy provided to the load is more than the energy used to charge the electrodes.

Abstract: A device and related method for producing electrical energy, in the form of current flowing in a load. The said method uses two solutions with different ionic concentration as energy source. The said device includes at least two electrodes immersed at least partially in a liquid contained in a cell. The method includes a plurality of phases. Among them, a phase in which the electrodes and are brought into contact with a first solution; a phase in which they are electrically charged; a phase in which they are brought into contact with a second solution; a phase in which at least a part of the accumulated charge is let flow through the load. The energy provided to the load is more than the energy used to charge the electrodes.