Patents by Inventor Chih-Ming J. Chen

Chih-Ming J. Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • In-vial deposition of 7-(dimethylaminomethylene)amino-9.alpha.-methoxymitosane
    Patent number: 4792566
    Abstract: There is disclosed a process for the in-vial deposition of 7-(dimethylaminomethylene)amino-9a-methoxymitosane in sterile unit dosage form. A solution of this compound is introduced into a sterile vial in a solution of tertiary-butanol. The tertiary-butanol is then removed, e.g., by evaporation or lyophilization, and the vial is closed by appropriate means. The thus deposited material can contain up to 0.5 mole equivalent of tertiary-butanol as a hemi-solvate and is very stable to heat.
    Type: Grant
    Filed: May 14, 1986
    Date of Patent: December 20, 1988
    Assignee: Bristol-Myers Company
    Inventors: Murray A. Kaplan, Dolatrai M. Vyas, Nagaswara R. Palepu, Chih-Ming J. Chen
  • Small particule formation and encapsulation
    Patent number: 4608278
    Abstract: The present invention is concerned with the simultaneous formation and encapsulation of small particles from aqueous solutions of compounds whose solubility is greater at a first pH than at a second pH. The process is preferably used to prepare a readily soluble encapsulated pharmaceutically active compound.
    Type: Grant
    Filed: June 15, 1984
    Date of Patent: August 26, 1986
    Assignee: The Ohio State University Research Foundation
    Inventors: Sylvan G. Frank, Arne F. Brodin, Chih-Ming J. Chen, Siriporn Panthuvanich
  • Small particle formation
    Patent number: 4606939
    Abstract: The present invention is concerned with the simultaneous formation and encapsulation of small particles of organic compounds whose solubility in water is greater at a first pH than at a second pH by concurrently precipitating said organic compounds as small particles and forming a coacervate of an anionic (or cationic) surfactant and an amphoteric surfactant. The process is preferably used to prepare a readily soluble encapsulated pharmaceutically active compound.
    Type: Grant
    Filed: June 15, 1984
    Date of Patent: August 19, 1986
    Assignee: The Ohio State University Research Foundation
    Inventors: Sylvan G. Frank, Arne F. Brodin, Chih-Ming J. Chen, Ratnesh Shrivastava