Patents by Inventor Chika Itoh
Chika Itoh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8828373Abstract: A polyalkylene glycol derivative containing a compound of the formula (1): wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, the groups represented by OA2 are the same or different from each other in one molecule, m is an average number of moles of the above oxyalkylene group added, m represents 10 to 1000, X represents a functional group capable of chemically reacting with a bio-related substance, and Y is a linker and represents an ether bond, an amide bond, a urethane bond, an ester bond, a secondary amino group, a carbonate bond, or an alkylene group containing these bonds, polydispersity Mw/Mn of the above polyalkylene glycol derivative in gel permeation chromatography satisfying the following relationship: Mw/Mn?1.08 wherein Mw represents a weight average molecular weight and Mn represents a number average molecular weight.Type: GrantFiled: June 2, 2005Date of Patent: September 9, 2014Assignee: NOF CorporationInventors: Ken-ichiro Nakamoto, Syunsuke Ohashi, Yuji Yamamoto, Kenji Sakanoue, Chika Itoh, Tohru Yasukohchi
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Patent number: 8785660Abstract: Provided are a thiol-reactive polyoxyalkylene-modified lipid which can be used to chemically modify bioactive substances and which can be used for drug delivery systems such as liposomes and a method for producing the same. The polyoxyalkylene-modified lipid is represented by the following formula (1): (wherein, R1 and R2 are hydrocarbon groups which are the same as or different from each other and which contain 4 to 24 carbon atoms, R3 is a divalent hydrocarbon group containing 1 to 6 carbon atoms, OA is oxyalkylene groups containing 2 to 4 carbon atoms, n is the average addition mole number of the oxyalkylene groups and is 5 to 1,000, and Z is a group containing either maleimide or iodoacetamide.Type: GrantFiled: March 27, 2012Date of Patent: July 22, 2014Assignee: NOF CorporationInventors: Satoshi Matsuo, Yuji Yamamoto, Chika Itoh
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Patent number: 8716435Abstract: A multibranched polyoxyalkylene compound represented by the following formula (1): wherein R1 is the same or different and is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are the same or different and are an oxyalkylene group having 2 to 4 carbon atoms, n and m are the same or different and are an average number of moles of the oxyalkylene group added, n represents 0 to 1000, m is the same or different and represents 10 to 1000, X represents a functional group capable of reacting with an amino group, a mercapto group, an aldehyde group, a carboxyl group, a triple bond, or an azide group to form a chemical bond, and L1 and L2 are the same or different and are a single bond, an alkylene group, or an alkylene group in which at least one bond selected from an ester bond, a urethane bond, an amide bond, an ether bond, and an amino is interposed.Type: GrantFiled: March 31, 2010Date of Patent: May 6, 2014Assignee: NOF CorporationInventors: Tsuyoshi Takehana, Ken-ichiro Nakamoto, Chika Itoh
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Patent number: 8569444Abstract: A process for producing a polyalkylene glycol derivative having such high molecular weight and purity that the derivative can be used in pharmaceutical applications, which produces a polyalkylene glycol derivative of the formula (X) by steps (A), (B), (C) and (D), wherein R is as defined: R—(OA)nOH??(X) (step (A)) 5 to 50% by mol of an alkali catalyst is added to a compound represented by the formula (Y), wherein R is as defined: R—OH??(Y) (step (B)) an alkylene oxide having 2 to 4 carbon atoms is reacted under a condition of 50 to 130° C. until the average number of moles of an oxyalkylene group OA added reaches the range of 5 to 500 to obtain a polyalkylene glycol derivative; (step (C)) 10 to 5000% by mass of a hydrocarbon solvent is added to the derivative of the step (B) to dilute it, and remaining water is removed by azeotropy; and (step (D)) the derivative of the step (B) is reacted with an alkylene oxide having 2 to 4 carbon atoms under a condition of 50 to 130° C.Type: GrantFiled: November 11, 2009Date of Patent: October 29, 2013Assignee: NOF CorporationInventors: Ken-ichiro Nakamoto, Chika Itoh, Shuichi Yoshimura, Tsuyoshi Takehana
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Patent number: 8501998Abstract: A method for producing a polyoxyalkylene derivative represented by the following general formula (1): Z(OA)n-OH]m??(1) wherein Z is a residue of glycerin or diglycerin, OA is an oxyalkylene group having 2 to 4 carbon atoms, n is an average number of moles of the oxyalkylene group added and is 80 to 800, and m is 3 to 4, the method comprising steps (A), (B), (C), (D), (E), and (F) defined in the present description.Type: GrantFiled: March 31, 2010Date of Patent: August 6, 2013Assignee: NOF CorporationInventors: Satoshi Matsuo, Kazuhiro Hashimoto, Ken-ichiro Nakamoto, Chika Itoh
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Publication number: 20120253053Abstract: Provided are a thiol-reactive polyoxyalkylene-modified lipid which can be used to chemically modify bioactive substances and which can be used for drug delivery systems such as liposomes and a method for producing the same. The polyoxyalkylene-modified lipid is represented by the following formula (1): (wherein, R1 and R2 are hydrocarbon groups which are the same as or different from each other and which contain 4 to 24 carbon atoms, R3 is a divalent hydrocarbon group containing 1 to 6 carbon atoms, OA is oxyalkylene groups containing 2 to 4 carbon atoms, n is the average addition mole number of the oxyalkylene groups and is 5 to 1,000, and Z is a group containing either maleimide or iodoacetamide.Type: ApplicationFiled: March 27, 2012Publication date: October 4, 2012Applicant: NOF CORPORATIONInventors: Matsuo Satoshi, Yuji Yamamoto, Chika Itoh
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Patent number: 8097692Abstract: A purification method in which, from a specific polyoxyalkylene derivative having a molecular weight of 8,800 to 100,000, an impurity differing in the number of hydroxyl groups is separated, the method including steps (A), (B), (C), and (D). Step (A): a step in which an aprotic organic solvent is used in an amount at least 5 times by weight the amount of the polyoxyalkylene derivative to dissolve the polyoxyalkylene derivative therein and give a solution; step (B): a step in which an adsorbent comprising an oxide containing at least one of aluminum and silicon is added to the solution in an amount 0.5 to 5 times by weight the amount of the polyoxyalkylene derivative to thereby yield a slurry; step (C): a step in which the slurry is stirred at 25° C. or higher; step (D): a step in which the polyoxyalkylene derivative is recovered from the slurry.Type: GrantFiled: March 31, 2010Date of Patent: January 17, 2012Assignee: NOF CorporationInventors: Shuichi Yoshimura, Ken-ichiro Nakamoto, Chika Itoh
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Patent number: 8034981Abstract: A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.Type: GrantFiled: November 9, 2010Date of Patent: October 11, 2011Assignee: NOF CorporationInventors: Ken-ichiro Nakamoto, Syunsuke Ohashi, Yuji Yamamoto, Kenji Sakanoue, Chika Itoh, Tohru Yasukohchi
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Publication number: 20110218322Abstract: An object of the present invention is to provide a process for producing a polyalkylene glycol derivative having such high molecular weight and purity that the derivative can be used in pharmaceutical applications. The production process of the invention produces a polyalkylene glycol derivative of the formula (X) by steps (A), (B), (C), (D), and (E). R—(OA)nOH??(X) (Step (A)) 5 to 50% by mol of an alkali catalyst is added to a compound represented by the formula (Y). R—OH??(Y) (Step (B)) An alkylene oxide having 2 to 4 carbon atoms is reacted under a condition of 50 to 130° C. until the average number of moles of an oxyalkylene group OA added reaches the range of 5 to 500 to obtain a polyalkylene glycol derivative. (Step (C)) 10 to 5000% by mass of a hydrocarbon solvent is added to the derivative of the step (B) to dilute it, and remaining water is removed by azeotropy.Type: ApplicationFiled: November 11, 2009Publication date: September 8, 2011Applicant: NOF CORPORATIONInventors: Ken-ichiro Nakamoto, Chika Itoh, Shuichi Yoshimura, Tsuyoshi Takehana
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Patent number: 8003117Abstract: A polyalkylene glycol derivative containing a compound of the formula (1): wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA2 is an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, the groups represented by OA2 are the same or different from each other in one molecule, m is an average number of moles of the oxyalkylene group added, m represents 10 to 1000, and X represents a functional group capable of chemically reactive with a bio-related substance, polydispersity Mw/Mn of the above polyalkylene glycol derivative in gel permeation chromatography satisfying the following relationship: Mw/Mn?1.07 wherein Mw represents a weight average molecular weight and Mn represents a number average molecular weight.Type: GrantFiled: June 2, 2005Date of Patent: August 23, 2011Assignee: NOF CorporationInventors: Ken-ichiro Nakamoto, Syunsuke Ohashi, Yuji Yamamoto, Kenji Sakanoue, Chika Itoh, Tohru Yasukohchi
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Publication number: 20110082277Abstract: A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.Type: ApplicationFiled: November 9, 2010Publication date: April 7, 2011Applicant: NOF CORPORATIONInventors: Ken-ichiro Nakamoto, Syunsuke Ohashi, Yuji Yammamoto, Kenji Sakanoue, Chika Itoh, Tohru Yasukohchi
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Patent number: 7851491Abstract: A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.Type: GrantFiled: March 6, 2009Date of Patent: December 14, 2010Assignee: NOF CorporationInventors: Ken-ichiro Nakamoto, Syunsuke Ohashi, Yuji Yamamoto, Kenji Sakanoue, Chika Itoh, Tohru Yasukohchi
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Publication number: 20100286361Abstract: A purification method in which, from a specific polyoxyalkylene derivative having a molecular weight of 8,800 to 100,000, an impurity differing in the number of hydroxyl groups is separated, the method including steps (A), (B), (C), and (D). Step (A): a step in which an aprotic organic solvent is used in an amount at least 5 times by weight the amount of the polyoxyalkylene derivative to dissolve the polyoxyalkylene derivative therein and give a solution; step (B): a step in which an adsorbent comprising an oxide containing at least one of aluminum and silicon is added to the solution in an amount 0.5 to 5 times by weight the amount of the polyoxyalkylene derivative to thereby yield a slurry; step (C): a step in which the slurry is stirred at 25° C. or higher; step (D): a step in which the polyoxyalkylene derivative is recovered from the slurry.Type: ApplicationFiled: March 31, 2010Publication date: November 11, 2010Applicant: NOF CORPORATIONInventors: Shuichi YOSHIMURA, Ken-ichiro NAKAMOTO, Chika ITOH
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Publication number: 20100261863Abstract: A multibranched polyoxyalkylene compound represented by the following formula (1): CH2-L1-(OA1)n-L2-X CH(OA2)mOR1 CH(OA2)mOR1 CH(OA2)mOR1 CH2(OA2)mOR1 ??(1) wherein R1 is the same or different and is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are the same or different and are an oxyalkylene group having 2 to 4 carbon atoms, n and m are the same or different and are an average number of moles of the oxyalkylene group added, n represents 0 to 1000, m is the same or different and represents 10 to 1000, X represents a functional group capable of reacting with an amino group, a mercapto group, an aldehyde group, a carboxyl group, a triple bond, or an azide group to form a chemical bond, and L1 and L2 are the same or different and are a single bond, an alkylene group, or an alkylene group in which at least one bond selected from an ester bond, a urethane bond, an amide bond, an ether bond, and an amino is interposed.Type: ApplicationFiled: March 31, 2010Publication date: October 14, 2010Applicant: NOF CORPORATIONInventors: Tsuyoshi TAKEHANA, Ken-ichiro NAKAMOTO, Chika ITOH
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Publication number: 20100256423Abstract: A method for producing a polyoxyalkylene derivative represented by the following general formula (1): Z?(OA)n—OH]m??(1) wherein Z is a residue of glycerin or diglycerin, OA is an oxyalkylene group having 2 to 4 carbon atoms, n is an average number of moles of the oxyalkylene group added and is 80 to 800, and m is 3 to 4, the method comprising steps (A), (B), (C), (D), (E), and (F) defined in the present description.Type: ApplicationFiled: March 31, 2010Publication date: October 7, 2010Applicant: NOF CORPORATIONInventors: Satoshi MATSUO, Kazuhiro HASHIMOTO, Ken-ichiro NAKAMOTO, Chika ITOH
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Publication number: 20090192320Abstract: A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.Type: ApplicationFiled: March 6, 2009Publication date: July 30, 2009Applicant: NOF CORPORATIONInventors: Ken-ichiro NAKAMOTO, Syunsuke Ohashi, Yuji Yamamoto, Kenji Sakanoue, Chika Itoh, Tohru Yasukohchi
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Patent number: 7531604Abstract: A phospholipid derivative, utilizable for modification of liposomes and the like, which is a copolymer containing, as essential component units, a component unit A represented by the formula (1), a component unit B represented by the formula (2A) and/or the formula (2B), and a component unit C represented by the formula (3) [R1 and R2 represent hydrogen atom or methyl group, provided that R1 and R2 do not simultaneously represent methyl group; R3 represents a divalent hydrocarbon group having 1 to 3 carbon atoms; AO represents an oxyalkylene group having 2 to 4 carbon atoms; m represents an average molar number of the added oxyalkylene groups and is a number in the range represented as 4?m?100; R4 represents hydrogen atom, a hydrocarbon group or acyl group having 1 to 20 carbon atoms; R5CO and R6CO represent an acyl group having 8 to 24 carbon atoms; R7 represents a divalent hydrocarbon group having 2 to 4 carbon atoms; and X and Y represent hydrogen atom, an alkali metal atom, ammonium or an organic ammoniumType: GrantFiled: September 30, 2003Date of Patent: May 12, 2009Assignees: NOF Corporation, Daiichi Pharmaceutical Co., Ltd.Inventors: Syunsuke Ohhashi, Kazuhiro Kubo, Chika Itoh, Tohru Yasukohchi, Hiroshi Kikuchi, Norio Suzuki, Miho Kurosawa, Hitoshi Yamauchi
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Patent number: 7524875Abstract: A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.Type: GrantFiled: June 2, 2005Date of Patent: April 28, 2009Assignee: NOF CorporationInventors: Ken-ichiro Nakamoto, Syunsuke Ohashi, Yuji Yamamoto, Kenji Sakanoue, Chika Itoh, Tohru Yasukohchi
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Patent number: 7524981Abstract: A phospholipid derivative represented by the following formula (1): wherein [PG]k represents a residue of polyglycerin having a polymerization degree of k, wherein k is 2 to 50, R1CO and R2CO independently represent an acyl group having 8 to 22 carbon atoms, symbol “a” independently represents an integer of 0 to 5, symbol “b” independently represents 0 or 1, M represents hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium, and k1, k2, and k3 represent numbers satisfying the following conditions: 1?k1?(k+2)/2, 0?k2, and k1+k2+k3=k+2. The phospholipid derivative is highly safe for living bodies and can be suitably utilized in drug delivery systems such as liposome, and the like.Type: GrantFiled: December 12, 2003Date of Patent: April 28, 2009Assignees: NOF Corporation, DAIICHI Pharmaceutical Co., Ltd.Inventors: Kazuhiro Kubo, Chika Itoh, Syunsuke Ohhashi, Tohru Yasukohchi, Yusuke Ohkawa, Hiroshi Kikuchi, Norio Suzuki, Miho Takahashi, Hitoshi Yamauchi
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Patent number: 7495116Abstract: A phospholipid derivative represented by the formula (1) (Z represents a residue of a compound having 3 to 10 hydroxyl groups; AO represents an oxyalkylene group having 2 to 4 carbon atoms; R1CO and R2CO represent an acyl group having 8 to 22 carbon atoms; X represents hydrogen atom, an alkali metal atom, ammonium or an organic ammonium; “a” represents an integer of 0 to 4; “b” represents 0 or 1; Q represents hydrogen atom or methyl group; m represents an average number of moles of the oxyalkylene group added; and m, k1, k2, and k3 are numbers satisfying the following conditions: 3?m?200, 9?m×(k1+k2+k3)?1000, 1?k1?2, 0?k2?9 and 0?k3?9, and 3?k1+k2+k3?10), which is highly safe for living bodies, and is suitably used for solubilization and dispersion of physiologically active substances and the like, or in the fields of drug delivery systems such as liposomes and cosmetics.Type: GrantFiled: March 28, 2003Date of Patent: February 24, 2009Assignees: NOF Corporation, Daiichi Pharmaceutical Co., Ltd.Inventors: Chika Itoh, Kazuhiro Kubo, Syunsuke Ohhashi, Tohru Yasukohchi, Hiroshi Kikuchi, Norio Suzuki, Miho Takahashi, Hitoshi Yamauchi