Patents by Inventor Chris B. FONG

Chris B. FONG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ultrapurified DsbA and DsbC and methods of making and using the same
    Patent number: 10690671
    Abstract: The present invention provides methods for producing disulfide oxidoreductase A (DsbA) and disulfide oxidoreductase C (DsbC) polypeptides at very high levels of purity. Also provided are ultrapure DsbA and DsbC and methods of using same, e.g., for use in immunoassays to show removal of DsbA and DsbC from biologics produced in bacteria.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: June 23, 2020
    Assignee: Genentech, Inc.
    Inventors: Marc Wong, Liliana T. Yee, Amy Lim, Chris B. Fong
  • ULTRAPURIFIED DsbA AND DsbC AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20190056399
    Abstract: The present invention provides methods for producing disulfide oxidoreductase A (DsbA) and disulfide oxidoreductase C (DsbC) polypeptides at very high levels of purity. Also provided are ultrapure DsbA and DsbC and methods of using same, e.g., for use in immunoassays to show removal of DsbA and DsbC from biologics produced in bacteria.
    Type: Application
    Filed: July 24, 2018
    Publication date: February 21, 2019
    Applicant: Genentech, Inc.
    Inventors: Marc Wong, Liliana T. Yee, Amy Lim, Chris B. Fong
  • PURIFICATION OF FKPA AND USES THEREOF FOR PRODUCING RECOMBINANT POLYPEPTIDES
    Publication number: 20180327446
    Abstract: The present invention provides methods for producing FKBP-type peptidyl-prolyl cis-trans isomerase (FkpA) polypeptides at very high levels of purity. Also provided we ultrapure FkpA and methods of using same, e.g., for use in immunoassays to show removal of FkpA from biologics produced in bacteria. In addition, the present invention provides methods of purifying polypeptides (e.g., multispecific antibodies) produced in bacteria overexpressing one or more chaperones. The methods include affinity chromatography, mixed-mode chromatography and hydrophobic interaction chromatography. in some aspects, the invention provides compositions of polypeptides (e.g., multispecific antibodies) that are essentially fee of product-specific impurities.
    Type: Application
    Filed: February 16, 2018
    Publication date: November 15, 2018
    Inventors: Chris B. Fong, Asif Ladiwala, Patrick A. McKay
  • Ultrapurified DsbA and DsbC and methods of making and using the same
    Patent number: 10073098
    Abstract: The present invention provides methods for producing disulfide oxidoreductase A (DsbA) and disulfide oxidoreductase C (DsbC) polypeptides at very high levels of purity. Also provided are ultrapure DsbA and DsbC and methods of using same, e.g., for use in immunoassays to show removal of DsbA and DsbC from biologics produced in bacteria.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: September 11, 2018
    Assignee: Genentech, Inc.
    Inventors: Marc Wong, Liliana T. Yee, Amy Lim, Chris B. Fong
  • ULTRAPURIFIED DsbA AND DsbC AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20160370369
    Abstract: The present invention provides methods for producing disulfide oxidoreductase A (DsbA) and disulfide oxidoreductase C (DsbC) polypeptides at very high levels of purity. Also provided are ultrapure DsbA and DsbC and methods of using same, e.g., for use in immunoassays to show removal of DsbA and DsbC from biologics produced in bacteria.
    Type: Application
    Filed: March 4, 2016
    Publication date: December 22, 2016
    Inventors: Marc WONG, Liliana T. YEE, Amy LIM, Chris B. FONG