Patents by Inventor Chris D. Geddes

Chris D. Geddes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Microwave accelerated assays
    Patent number: 8318087
    Abstract: The present invention provides for increasing fluorescence detection in surface assay systems while increasing kinetics of a bioreaction therein by providing low-power microwaves to irradiate metallic materials within the system in an amount sufficient to increase heat thereby affecting the kinetics of a bioreaction therein.
    Type: Grant
    Filed: October 6, 2011
    Date of Patent: November 27, 2012
    Assignee: University of Maryland, Baltimore County
    Inventor: Chris D. Geddes
  • MIXED-METAL SUBSTRATES FOR METAL-ENHANCED FLUORESCENCE
    Publication number: 20120282630
    Abstract: The present invention provides for mixed metal structures that can be deposited on a substrate or free in solution that exhibit several distinctive properties including a broad wavelength range for enhancing fluorescence signatures. Further, metal surface plasmons can couple and such diphase coupled luminescence signatures create extra plasmon absorption bands. The extra bands allow for a broad range of fluorophores to couple therefore making more generic substrates with wider reaching applications.
    Type: Application
    Filed: December 17, 2010
    Publication date: November 8, 2012
    Inventor: Chris D. Geddes
  • MULTICOLOR MICROWAVE-ACCELERATED METAL-ENHANCED FLUORESCENCE (M-MAMEF)
    Publication number: 20120238035
    Abstract: The present invention relates to the use of multiple different light emitting molecules that emit different and detectable emission signals to provide systems and methods to detect different target products in a single assay sample, wherein the different light emitting molecules are positioned an optimal distance from metallic particles thereby enhancing emissions. Preferably, the systems and methods further comprise use of either microwave or sonic energy to increase binding reactions, timing of such reactions within the assay sample and reduce background non-specific biological absorption.
    Type: Application
    Filed: March 15, 2012
    Publication date: September 20, 2012
    Inventor: CHRIS D. GEDDES
  • HIGH-SENSITIVITY ASSAYS FOR PATHOGEN DETECTION USING METAL-ENHANCED FLUORESCENCE
    Publication number: 20120142552
    Abstract: The present invention relates to an assay including a surface having silver colloids or islands attached thereto. Attached to the surface and/or silver colloids/islands are polynucleotides which are complimentary to a target polynucleotide sequence. The assay is performed by adding the target polynucleotide sequence to the assay surface and allowed to hybridize with the capture polynucleotides. Fluorophore-labeled capture polynucleotides are added and hybridize to the target polynucleotide. Bound target polynucleotides are detected by metal enhanced fluorescence.
    Type: Application
    Filed: February 14, 2012
    Publication date: June 7, 2012
    Inventors: CHRIS D. GEDDES, JOSEPH R. LAKOWICZ, LESLIE W.J. BAILLIE
  • Metal-enhanced fluorescence from plastic substrates
    Patent number: 8182878
    Abstract: The present invention relates to methods for functionally modifying a polymeric surface for subsequent deposition of metallic particles and/or films, wherein the polymeric surface is modified by increasing hydroxyl and/or amine functional groups thereby providing an activated polymeric surface for deposition of metallic particles to form a fluorescence sensing device. The device can be used for metal-enhanced fluorescence of fluorophores positioned above the metallic particles that can be readily applied to diagnostic or sensing applications of metal-enhanced fluorescence.
    Type: Grant
    Filed: November 22, 2011
    Date of Patent: May 22, 2012
    Assignee: University of Maryland, Baltimore County
    Inventors: Chris D. Geddes, Kadir Aslan
  • BIOASSAYS USING PLASMONIC SCATTERING FROM NOBLE METAL NANOSTRUCTURES
    Publication number: 20120122240
    Abstract: The present invention relates to detecting and/or measuring scattering effects due to the aggregating metallic nanostructures or the interaction of plasmonic emissions from approaching metallic nanoparticles. The scattering effects may be measured at different angles, different wavelengths, changes in absorption and/or changes in polarization relative to changes in the distances between nanoparticles.
    Type: Application
    Filed: January 23, 2012
    Publication date: May 17, 2012
    Inventor: Chris D. Geddes
  • MICROWAVE-ACCELERATED PLASMONICS
    Publication number: 20120107952
    Abstract: The present invention relates to systems and methods using microwave accelerated surface plasmonics for the detection of target species, wherein the system has a metallic surface and the system is exposed to microwave energy for increasing detection time and/or the reaction kinetics of the target species and other interacting participants in the system and wherein plasmonic emissions from the metallic surface alone or coupled with emissions from a luminescing entity are detected.
    Type: Application
    Filed: April 2, 2007
    Publication date: May 3, 2012
    Applicant: UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE
    Inventors: Chris D. Geddes, Kadir Aslan
  • PLASMONIC ELECTRICITY
    Publication number: 20120091349
    Abstract: The present invention relates to detection systems and methods that detect fluorescence, luminescence, chemiluminescence or phosphorescence signatures in the form of an electrical signal conducted and emitted from metallic containing surfaces. Thus, the present invention provides for detecting fluorescence digitally and directly without the need for expensive detectors.
    Type: Application
    Filed: September 17, 2009
    Publication date: April 19, 2012
    Inventor: Chris D. Geddes
  • METAL-ENHANCED FLUORESCENCE FROM PLASTIC SUBSTRATES
    Publication number: 20120063955
    Abstract: The present invention relates to methods for functionally modifying a polymeric surface for subsequent deposition of metallic particles and/or films, wherein the polymeric surface is modified by increasing hydroxyl and/or amine functional groups thereby providing an activated polymeric surface for deposition of metallic particles to form a fluorescence sensing device. The device can be used for metal-enhanced fluorescence of fluorophores positioned above the metallic particles that can be readily applied to diagnostic or sensing applications of metal-enhanced fluorescence.
    Type: Application
    Filed: November 22, 2011
    Publication date: March 15, 2012
    Inventors: CHRIS D. GEDDES, KADIR ASLAN
  • High-sensitivity assays for pathogen detection using metal enhanced fluorescence
    Patent number: 8114598
    Abstract: The present invention relates to an assay including a surface having silver colloids or islands attached thereto. Attached to the surface and/or silver colloids/islands are polynucleotides which are complimentary to a target polynucleotide sequence. The assay is performed by adding the target polynucleotide sequence to the assay surface and allowed to hybridize with the capture polynucleotides. Fluorophore-labeled capture polynucleotides are added and hybridize to the target polynucleotide. Bound target polynucleotides are detected by metal enhanced fluorescence.
    Type: Grant
    Filed: November 26, 2003
    Date of Patent: February 14, 2012
    Assignee: University of Maryland, Baltimore County
    Inventors: Chris D. Geddes, Joseph R. Lakowitz, Leslie W. J. Baillie
  • METAL-ENHANCED BIOLUMINESCENCE: AN APPROACH FOR MONITORING BIOLOGICAL BIOLUMINESCENT PROCESSES
    Publication number: 20120028270
    Abstract: The present invention relates to surface plasmon-coupled bioluminescence, wherein bioluminescent emission from a bioluminescent chemical reaction couples to surface plasmons in metallized particles thereby enhancing the signal. Importantly, these plasmonic emissions emitted from metallic particles generated without an external excitation source but instead from induced electronically excited states caused by the bioluminescent chemical reaction.
    Type: Application
    Filed: February 17, 2010
    Publication date: February 2, 2012
    Inventor: Chris D. Geddes
  • MICROWAVE ACCELERATED ASSAYS
    Publication number: 20120028849
    Abstract: The present invention provides for increasing fluorescence detection in surface assay systems while increasing kinetics of a bioreaction therein by providing low-power microwaves to irradiate metallic materials within the system in an amount sufficient to increase heat thereby affecting the kinetics of a bioreaction therein.
    Type: Application
    Filed: October 6, 2011
    Publication date: February 2, 2012
    Inventor: CHRIS D. GEDDES
  • DIRECTIONAL SURFACE PLASMON COUPLED FLUORESCENCE AND CHEMILUMINESCENCE FROM THIN FILMS OF NICKEL, IRON OR PALLADIUM AND USES THEREOF
    Publication number: 20120021443
    Abstract: Nickel, iron and palladium thin films thermally evaporated onto glass supports are used to demonstrate surface plasmon coupled fluorescence (SPCF) and surface plasmon couple chemiluminescence (SPCC) over a broad wavelength range (400-800 nm) for potential assays or other detection systems. Nickel, iron and palladium thin films used in SPCF and SPCC convert otherwise isotropic emission into highly directional and polarized emission, an attractive concept for surface assays. The emission angles of detected emissions occur over a 10 degree range for tested emitted wavelengths.
    Type: Application
    Filed: February 23, 2010
    Publication date: January 26, 2012
    Inventor: Chris D. Geddes
  • Bioassays using plasmonic scattering from noble metal nanostructures
    Patent number: 8101424
    Abstract: The present invention relates to detecting and/or measuring scattering effects due to the aggregating metallic nanostructures or the interaction of plasmonic emissions from approaching metallic nanoparticles. The scattering effects may be measured at different angles, different wavelengths, changes in absorption and/or changes in polarization relative to changes in the distances between nanoparticles.
    Type: Grant
    Filed: June 15, 2006
    Date of Patent: January 24, 2012
    Assignee: University of Maryland, Baltimore County
    Inventor: Chris D. Geddes
  • Metal-enhanced fluorescence from plastic substrates
    Patent number: 8075956
    Abstract: The present invention relates to methods for functionally modifying a polymeric surface for subsequent deposition of metallic particles and/or films, wherein the polymeric surface is modified by increasing hydroxyl and/or amine functional groups thereby providing an activated polymeric surface for deposition of metallic particles to form a fluorescence sensing device. The device can be used for metal-enhanced fluorescence of fluorophores positioned above the metallic particles that can be readily applied to diagnostic or sensing applications of metal-enhanced fluorescence.
    Type: Grant
    Filed: October 28, 2005
    Date of Patent: December 13, 2011
    Assignee: University of Maryland, Baltimore County
    Inventors: Chris D. Geddes, Kadir Aslan
  • METAL ENHANCED FLUORESCENCE-BASED SENSING METHODS
    Publication number: 20110294997
    Abstract: The present invention relates to metallic-surface detection systems for determining target substances including free bilirubin in neonatal serum in the presence of a predominantly high background of bilirubin bound Human Serum Albumin (HSA) or sensing and isolating target nucleotide sequences wherein a fluorescence signal is enhanced by close proximity of the target substances near metallic surfaces.
    Type: Application
    Filed: May 10, 2011
    Publication date: December 1, 2011
    Inventor: CHRIS D. GEDDES
  • Microwave accelerated assays
    Patent number: 8034633
    Abstract: The present invention provides for increasing fluorescence detection in surface assay systems while increasing kinetics of a bioreaction therein by providing low-power microwaves to irradiate metallic materials within the system in an amount sufficient to increase heat thereby affecting the kinetics of a bioreaction therein.
    Type: Grant
    Filed: November 21, 2005
    Date of Patent: October 11, 2011
    Assignee: University of Maryland, Baltimore County
    Inventor: Chris D. Geddes
  • Microwave trigger metal-enhanced chemiluminescence (MT MEC) and spatial and temporal control of same
    Patent number: 8008067
    Abstract: The present invention relates to a method of imaging structures and features using plasmonic emissions from metallic surfaces caused by chemiluminescence based chemical and biological reactions wherein imaging of the reactions is enhanced by the use of microwave energy and further enhanced by using metallic geometric structures for spatially and temporally controlling the biological and chemical reactions.
    Type: Grant
    Filed: February 25, 2008
    Date of Patent: August 30, 2011
    Assignee: University of Maryland, Baltimore County
    Inventors: Chris D. Geddes, Michael Previte
  • SONICATION-ASSISTED METAL-ENHANCED FLUORESCENCE (SAMEF)-BASED BIOASSAYS
    Publication number: 20110207236
    Abstract: The present invention provides for sonication-assisted metal-enhanced fluorescence, luminescence, and/or chemiluminescence assay systems using low-intensity ultrasound waves to significantly reduce the assay time by increasing the kinetic movement of molecules within the system.
    Type: Application
    Filed: September 11, 2009
    Publication date: August 25, 2011
    Inventor: Chris D. Geddes
  • VOLTAGE-GATED METAL-ENHANCED FLUORESCENCE, CHEMILUMINESCENCE OR BIOLUMINESCENCE METHODS AND SYSTEMS
    Publication number: 20110136154
    Abstract: In the present invention, it is demonstrated for the first time, the influence of electrical current on the ability of surface plasmons to amplify fluorescence signatures. An applied direct current across silver island films (SiFs) of low electrical resistance perturbs the fluorescence enhancement of close-proximity fluorophores. For a given applied current, surface plasmons in “just-continuous” low resistance films are sparsely available for fluorophore dipole coupling and hence the enhanced fluorescence is gated as a function of the applied current.
    Type: Application
    Filed: March 1, 2009
    Publication date: June 9, 2011
    Inventor: Chris D. Geddes