Abstract: Techniques for characterizing protein candidate sites are provided. Experimental data comprising spectral data from an experimental data source is received. Based on the experimental data, a data set comprising a set of protein candidate sites within one or more proteins is created. For each protein candidate site of the set of protein candidate sites, a feature set characterizing the respective protein candidate site is generated. A characterization of the amenability for drug-discovery for one or more of the protein candidate sites is generated by applying a classifier to the respective feature set for the protein candidate site.

Abstract: Techniques for characterizing protein candidate sites are provided. Experimental data comprising spectral data from an experimental data source is received. Based on the experimental data, a data set comprising a set of protein candidate sites within one or more proteins is created. For each protein candidate site of the set of protein candidate sites, a feature set characterizing the respective protein candidate site is generated. A characterization of the amenability for drug-discovery for one or more of the protein candidate sites is generated by applying a classifier to the respective feature set for the protein candidate site.

Abstract: The present invention relates to chemically modified, linked double-stranded (ds)RNA compositions comprising two or more double-stranded (ds) oligoribonucleotides linked by at least one linking moiety and methods of formulating and delivering such compositions to modulate gene expression through target-specific RNA co-interference (RNAco-i). The compositions of the invention may optionally comprise a conjugation or a complex with one or more small molecule drugs, protein therapeutics, or other dsRNA molecules. The present invention is directed at the methods of production for, methods of use of, and therapeutic utilities for RNAi co-interference therapy utilizing the compositions of the invention.

Abstract: The present invention relates to chemically modified, linked double-stranded (ds)RNA compositions comprising two or more double-stranded (ds) oligoribonucleotides linked by at least one linking moiety and methods of formulating and delivering such compositions to modulate gene expression through target-specific RNA co-interference (RNAco-i). The compositions of the invention may optionally comprise a conjugation or a complex with one or more small molecule drugs, protein therapeutics, or other dsRNA molecules. The present invention is directed at the methods of production for, methods of use of, and therapeutic utilities for RNAi co-interference therapy utilizing the compositions of the invention.