Abstract: This invention relates to tetrazoles and their use as inhibitors of TRPA1 activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of fibrotic diseases, inflammatory and auto-immune diseases and CNS-related diseases.

Abstract: This invention relates to novel (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles and their use as CB2 cannabinoid receptor agonists, pharmaceutical compositions containing the same, and their use for the treatment of CB2 receptor mediated disorders or conditions.

Abstract: The present disclosure provides certain piperidinylpyridinylcarbonitrile derivatives, and pharmaceutically acceptable salts thereof, that are inhibitors of Glutaminyl-peptide cyclotransferase (QPCT) and glutaminyl-peptide cyclotransferase-like protein (QPCTL), and are therefore useful for the treatment of diseases treatable by inhibition of QPCT/L. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.

Abstract: A brushless electrical machine, in particular, a brushless d.c. motor, having a housing, at least one rotor, which is positioned on a shaft rotationally mounted in the housing, and a stator attached to the housing; the rotor being assigned a rotor position detection device, which operates contactlessly and includes a multipole magnetic ring positioned on the shaft in a rotatably fixed manner and at least one sensor, which is sensitive to magnetic fields and is attached to the housing radially with respect to the outer circumference of the magnetic ring. The number of pole pairs of the rotor and the number of pole pairs of the magnetic ring are coprime.

Abstract: The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.

Abstract: The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.

Abstract: The present disclosure provides certain 3H,4H,5H,6H,7H-pyrimido[4,5-b][1,4]oxazine-4,6-dione derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.

Abstract: The present disclosure provides certain substituted 1,2,4-oxadiazole derivatives of the below formula (I) that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.

Abstract: The present disclosure provides certain uracil derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.

Abstract: Provided herein are improved anti-CD2 antibodies and methods for their use in the treatment and/or prevention of chronic or acute disorders of the immune system. Also provided herein are methods for treating or preventing an immune related disorder or disease in a subject by administering an anti-CD2 antibody or an antigen-binding fragment thereof and a CTLA-4 co-stimulation blockade. Compositions for use with these methods and kits are also disclosed.

Abstract: The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.

Abstract: This invention relates to novel (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles and their use as CB2 cannabinoid receptor agonists, pharmaceutical compositions containing the same, and their use for the treatment of CB2 receptor mediated disorders or conditions.

Abstract: A control apparatus/method for operating an electromechanical brake booster of a vehicle braking system, including: applying control to an electromechanical brake booster motor in consideration at least of a braking definition signal regarding a braking input of a driver and/or automatic speed control system of the vehicle (ACC); specifying, in consideration at least of the braking definition signal, a target motor force of the electromechanical brake booster motor or a target brake application force of the electromechanical brake booster into a brake master cylinder, downstream from the electromechanical brake booster, of the braking system; and applying control to the electromechanical brake booster motor in consideration of a force difference between the specified target motor force and an estimated/measured actual motor force of the motor, or between the specified target brake application force and an estimated/measured actual brake application force of the electromechanical brake booster into the downstr

Abstract: The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing the same.

Abstract: The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing the same.

Abstract: This invention relates to thienopyrimidinones and their use as inhibitors of TRPA1 activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of fibrotic diseases, inflammatory and auto-immune diseases and CNS-related diseases.

Abstract: The disclosure relates to a control device and a corresponding method for operating an electromechanical brake booster of a brake system of a vehicle, comprising an electronics unit that defines a target variable with respect to a target rotational speed of a motor of the electromechanical brake booster, taking into account a brake input signal with respect to a braking request, and that sends at least one control signal to the motor. The electronics unit defines a maximum target variable with respect to a maximum target rotational speed of the motor, taking into account a current intensity of a motor current of the motor and a current angle of rotation of a rotor of the motor, and defines the target variable with respect to the target rotational speed of the motor of the electromechanical brake booster to be at the most equal to the defined maximum target variable.

Abstract: In an electronic evaluation system for a vehicle braking system equipped with an electromechanical brake booster, a method for estimating a brake master cylinder pressure includes: estimating a first initial value of the pressure based on a first current intensity of a current of a motor of the booster at the first time and on a first rotation angle of a rotor of the motor at the first time; specifying a correction value as a difference between the first initial value and a measured value of the pressure; estimating a second initial value of the pressure based on a second current intensity of the current at the second time and on a second rotation angle of the rotor at the second time; and specifying, based on the second initial value and the correction value, an estimated value of the pressure at the second time.

Abstract: The present disclosure provides certain 3H,4H,5H,6H,7H-pyrimido[4,5-b][1,4]oxazine-4,6-dione derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.

Abstract: The present disclosure provides certain imidazo[4,5-d]pyridazinonyl derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.