Patents by Inventor Christian E. Gruber
Christian E. Gruber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120107879Abstract: The present invention is directed to methods for the production and isolation of nucleic acid molecules. In particular, the invention concerns isolation of mRNA molecules and the production and isolation of nucleic acid molecules (e.g., cDNA molecules or libraries), which may be single- or double-stranded. Additionally, the invention concerns selection and isolation of particular nucleic acid molecules of interest from a sample which may contain a population of molecules. Specifically, the invention concerns affinity-labeled primer-adapter molecules which allow improved isolation and production of such nucleic acid molecules, increasing both product recovery and speed of isolation.Type: ApplicationFiled: August 29, 2011Publication date: May 3, 2012Applicant: Life Technologies CorporationInventors: Christian E. GRUBER, Joel A. Jessee
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Publication number: 20110151521Abstract: The present invention generally relates to methods of making cDNA molecules and cDNA libraries. The invention also relates to cDNA molecules and cDNA libraries produced according to these methods, as well as to vectors and host cells containing such cDNA molecules and libraries. The invention also relates to kits for making the cDNA molecules and libraries of the invention.Type: ApplicationFiled: January 31, 2011Publication date: June 23, 2011Applicant: Life Technologies CorporationInventors: Wu Bo Li, Joel A. Jessee, Christian E. GRUBER
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Publication number: 20100317063Abstract: The present invention generally relates to methods of making cDNA molecules and cDNA libraries. The invention also relates to cDNA molecules and cDNA libraries produced according to these methods, as well as to vectors and host cells containing such cDNA molecules and libraries. The invention also relates to kits for making the cDNA molecules and libraries of the invention.Type: ApplicationFiled: November 21, 2009Publication date: December 16, 2010Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Wu Bo LI, Joel A. Jessee, Christian E. Gruber
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Publication number: 20100168408Abstract: The present invention is generally related to compositions, kits and methods for labeling nucleic acid molecules using reverse transcriptases, preferably multi-subunit reverse transcriptases such as ASLV reverse transcriptases. Specifically, the invention relates to methods, kits and compositions for to fluorescently labeling nucleic acid molecules during nucleic acid synthesis. The labeled nucleic acid molecules produced in accordance with the invention are particularly suited as labeled probes for nucleic acid detection and diagnostics.Type: ApplicationFiled: December 30, 2009Publication date: July 1, 2010Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Christian E. Gruber, Po-Jen Shih
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Publication number: 20100093989Abstract: The present invention is directed to methods for the production and isolation of nucleic acid molecules. In particular, the invention concerns isolation of mRNA molecules and the production and isolation of nucleic acid molecules (e.g., cDNA molecules or libraries), which may be single- or double-stranded. Additionally, the invention concerns selection and isolation of particular nucleic acid molecules of interest from a sample which may contain a population of molecules. Specifically, the invention concerns affinity-labeled primer-adapter molecules which allow improved isolation and production of such nucleic acid molecules, increasing both product recovery and speed of isolation.Type: ApplicationFiled: June 24, 2009Publication date: April 15, 2010Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: CHRISTIAN E. GRUBER, JOEL A. JESSEE
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Publication number: 20090176242Abstract: The present invention is generally related to compositions, kits and methods for labeling nucleic acid molecules using reverse transcriptases, preferably multi-subunit reverse transcriptases such as ASLV reverse transcriptases. Specifically, the invention relates to methods, kits and compositions for fluorescently labeling nucleic acid molecules during nucleic acid synthesis. The labeled nucleic acid molecules produced in accordance with the invention are particularly suited as labeled probes for nucleic acid detection and diagnostics.Type: ApplicationFiled: March 16, 2009Publication date: July 9, 2009Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Christian E. Gruber, Po-Jen Shih
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Publication number: 20080287321Abstract: The present invention generally relates to methods of making cDNA molecules and cDNA libraries. The invention also relates to cDNA molecules and cDNA libraries produced according to these methods, as well as to vectors and host cells containing such cDNA molecules and libraries. The invention also relates to kits for making the cDNA molecules and libraries of the invention.Type: ApplicationFiled: July 5, 2006Publication date: November 20, 2008Applicant: Invitrogen CorporationInventors: Wu Bo Li, Joel A. Jessee, Christian E. Gruber
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Publication number: 20080227107Abstract: The present invention is generally related to compositions, kits and methods for labeling nucleic acid molecules using reverse transcriptases, preferably multi-subunit reverse transcriptases such as ASLV reverse transcriptases. Specifically, the invention relates to methods, kits and compositions for fluorescently labeling nucleic acid molecules during nucleic acid synthesis. The labeled nucleic acid molecules produced in accordance with the invention are particularly suited as labeled probes for nucleic acid detection and diagnostics.Type: ApplicationFiled: April 29, 2008Publication date: September 18, 2008Applicant: INVITROGEN CORPORATIONInventors: Christian E. Gruber, Po-Jen Shih
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Patent number: 7074556Abstract: The present invention generally relates to methods of making cDNA molecules and cDNA libraries. The invention also relates to cDNA molecules and cDNA libraries produced according to these methods, as well as to vectors and host cells containing such cDNA molecules and libraries. The invention also relates to kits for making the cDNA molecules and libraries of the invention.Type: GrantFiled: February 29, 2000Date of Patent: July 11, 2006Assignee: Invitrogen CorporationInventors: Wu Bo Li, Joel A. Jessee, Christian E. Gruber
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Patent number: 7037661Abstract: The present invention is generally related to compositions, kits and methods for labeling nucleic acid molecules using reverse transcriptases, preferably multi-subunit reverse transcriptases such as ASLV reverse transcriptases. Specifically, the invention relates to methods, kits and compositions for fluorescently labeling nucleic acid molecules during nucleic acid synthesis. The labeled nucleic acid molecules produced in accordance with the invention are particularly suited as labeled probes for nucleic acid detection and diagnostics.Type: GrantFiled: April 3, 2003Date of Patent: May 2, 2006Assignee: Invitrogen CorporationInventors: Christian E. Gruber, Po-Jen Shih
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Publication number: 20040185493Abstract: The present invention is directed to methods for the production and isolation of nucleic acid molecules. In particular, the invention concerns isolation of mRNA molecules and the production and isolation of nucleic acid molecules (e.g., cDNA molecules or libraries), which may be single- or double-stranded. Additionally, the invention concerns selection and isolation of particular nucleic acid molecules of interest from a sample which may contain a population of molecules. Specifically the invention concerns affinity-labeled primer-adapter molecules which allow improved isolation and production of such nucleic acid molecules, increasing both product recovery and speed of isolation.Type: ApplicationFiled: April 5, 2004Publication date: September 23, 2004Applicant: Invitrogen CorporationInventors: Christian E. Gruber, Joel A. Jessee
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Publication number: 20030190661Abstract: The present invention is generally related to compositions, kits and methods for labeling nucleic acid molecules using reverse transcriptases, preferably multi-subunit reverse transcriptases such as ASLV reverse transcriptases. Specifically, the invention relates to methods, kits and compositions for fluorescently labeling nucleic acid molecules during nucleic acid synthesis. The labeled nucleic acid molecules produced in accordance with the invention are particularly suited as labeled probes for nucleic acid detection and diagnostics.Type: ApplicationFiled: April 3, 2003Publication date: October 9, 2003Applicant: Invitrogen CorporationInventors: Christian E. Gruber, Po-Jen Shih
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Patent number: 6589737Abstract: The present invention is generally related to compositions, kits and methods for labeling nucleic acid molecules using reverse transcriptases, preferably multi-subunit reverse transcriptases such as ASLV reverse transcriptases. Specifically, the invention relates to methods, kits and compositions for fluorescently labeling nucleic acid molecules during nucleic acid synthesis. The labeled nucleic acid molecules produced in accordance with the invention are particularly suited as labeled probes for nucleic acid detection and diagnostics.Type: GrantFiled: May 19, 2000Date of Patent: July 8, 2003Assignee: Invitrogen CorporationInventors: Christian E. Gruber, Po-Jen Shih
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Publication number: 20020039744Abstract: The present invention provides a method for the rapid isolation and recovery of a desired target DNA or RNA molecules from a mixture or library containing such molecules. The method involves the use of biotinylated probes and enzymatic repair-cleavage to eliminate undesired library members from a sample.Type: ApplicationFiled: December 5, 2001Publication date: April 4, 2002Inventors: Wu-Bo Li, Christian E. Gruber, Joel A. Jessee, Jhy-Jhu Lin
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Publication number: 20020028447Abstract: The present invention generally relates to methods of making cDNA molecules and cDNA libraries. The invention also relates to cDNA molecules and cDNA libraries produced according to these methods, as well as to vectors and host cells containing such cDNA molecules and libraries. The invention also relates to kits for making the cDNA molecules and libraries of the invention.Type: ApplicationFiled: February 29, 2000Publication date: March 7, 2002Inventors: Wu Bo Li, Joel A Jessee, Christian E Gruber
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Patent number: 5759778Abstract: The present invention provides a method for the rapid isolation and recovery of a desired target DNA or RNA molecules from a mixture or library containing such molecules. The method involves the use of biotinylated probes and enzymatic repair-cleavage to eliminate undesired library members from a sample.Type: GrantFiled: September 8, 1995Date of Patent: June 2, 1998Assignee: Life Technologies, Inc.Inventors: Wu-Bo Li, Christian E. Gruber, Joel A. Jessee, Jhy-Jhu Lin
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Patent number: 5500356Abstract: The present invention provides a method for the rapid isolation and recovery of a desired target DNA or RNA molecules from a mixture or library containing such molecules. The method involves the use of biotinylated probes and enzymatic repair-cleavage to eliminate undesired library members from a sample.Type: GrantFiled: August 10, 1993Date of Patent: March 19, 1996Assignee: Life Technologies, Inc.Inventors: Wu-Bo Li, Christian E. Gruber, Joel A. Jessee, Jhy-Jhu Lin