Abstract: The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes (I); wherein A is —C(R1)? or —N?; and X is selected from the group consisting of: (II-i), and (II-ii). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.

Abstract: A machine and a method for earth-working with a machine, having a mast, along which a top drive can be moved vertically by an adjusting device, through which top drive a telescopic kelly bar is displaceably guided, which has at least one outer kelly bar, which is designed to come to lie on the top drive, and one inner kelly bar, which comprises a rope suspension for a rope, through which the inner kelly bar is moved vertically by a rope winch. The adjusting device for the top drive and/or the main rope winch for the kelly bar is/are automatically controlled, wherein the inner kelly bar is moved relative to the top drive in some areas in a rapid travel mode at a first speed and in some areas in a conservative travel mode, in which the speed is reduced in comparison with the first speed.

Abstract: A method for the control of an industrial truck during order picking by an industrial truck with at least one environment sensor for the detection of the relative position of an operator in the environment of the industrial truck. The method includes moving the industrial truck using a control system. As the position of the operator changes, and when the operator stops, the industrial truck is stopped at a freely selectable distance specified in advance in the longitudinal direction of the vehicle between a reference point of a load handling device of the industrial truck and the position of the operator.

Abstract: A spectroscopic method for calculating a limit of quantification and a relative error includes: 1. selecting an error function F(C); 2. providing a blank spectrum; 3. recording a reference spectrum with a signal content of the substance being investigated; 4. determining start concentrations; 5.a. multiplying the reference spectrum with the signal content of the substance by a factor; 5.b. adding the resulting spectrum to the blank spectrum and determining the corresponding concentration of the substance and calculating the corresponding relative error; 6. iteratively adapting parameters of the selected error function F(C): recording a measurement spectrum of the test sample and determining the concentration of the substance being investigated using 5.b. and comparing with the calculated limit of quantification and calculating the relative error by applying the error function from step 6.

Abstract: A button cell has a winding arranged in the cup-shaped, positive-polarity housing half such that one of the flat end sides points in the direction of the cup base, the circumferential outer side thereof bears against the circumferential cup wall and the outer side together with the cup wall forms a clamping zone in which the first current output conductor is clamped.

Abstract: An information encoder for encoding an information signal includes: a converter for converting the linear prediction coefficients of the predictive polynomial A(z) to frequency values f1 . . . fn of a spectral frequency representation of the predictive polynomial A(z), wherein the converter is configured to determine the frequency values f1 . . . fn by analyzing a pair of polynomials P(z) and Q(z) being defined as P(z)=A(z)+z?m?lA(z?1) and Q(z)=A(z)?z?m?lA(z?1), wherein m is an order of the predictive polynomial A(z) and l is greater or equal to zero, wherein the converter is configured to obtain the frequency values by establishing a strictly real spectrum derived from P(z) and a strictly imaginary spectrum from Q(z) and by identifying zeros of the strictly real spectrum derived from P(z) and the strictly imaginary spectrum derived from Q(z).

Abstract: The invention relates to a grid arrangement for a plate-shaped battery electrode of an electrochemical accumulator comprising a frame and a grid arranged thereon, wherein the frame comprises at least one upper frame element having a connecting lug of the battery electrode disposed on its side facing away from the grid, wherein the grid comprises grid bars respectively surrounding cutouts of the grid, wherein the majority of the grid bars surrounding the cutouts are respectively disposed in a hexagonal arrangement such that the cutout situated in between forms a hexagon, characterized by one, some or all of the following a), b), c), d), e) features): a) the grid arrangement is coated with a pasty active mass on which liquid-absorbing material designed to absorb liquid electrolyte of the accumulator is disposed, b) the size of the hexagonal cutouts increases toward the upper frame element, c) the grid bars of all the hexagonal cutouts have the same width or the same cross-sectional area, d) none of the grid ba

Abstract: The invention provides certain substituted diazine and triazine compounds of the Formula (I) (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, Rcy, Cy, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.

Abstract: The invention provides certain substituted pyridines of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, Rcy, Cy, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.

Abstract: The present invention provides novel pyrimidine amines of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis and cancer.

Abstract: The present invention provides novel pyrazole derivatives of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.

Abstract: The invention provides certain 2-pyridyl carboxamide-containing compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein A and B are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.

Abstract: The present invention is directed to isotopically labeled biaryl urea compounds which possess high affinity to neurofibrillary tangles (NFTs), and thus are useful to determine the amount and distribution of NFTs in brain. The isotopically labeled biaryl urea compounds may also be useful as PET tracers and in competition assays to identify other compounds that may serve as PET tracers.

Abstract: The present invention provides novel pyrimidine amines of formula I which are potent inhibitors of spleen tyrosine kinase, or are prodrugs thereof, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis and cancer.

Abstract: A method for determining the concentration of a substance in a sample (91) calculates a plurality of intermediate spectra (ZW1, ZW2) from a measured reference spectrum (RS) of the substance. For calculating the intermediate spectra (ZW1, ZW2), the following individual steps are applied to the reference spectrum (RS): shifting the position in accordance with a shift parameter; multiplication with an amplitude factor; and convolution with a system function in accordance with a line broadening parameter. The shift parameter, the amplitude factor and the line broadening parameter are changed within the scope of an optimization algorithm that iteratively optimizes the correspondence between the intermediate spectra (ZW1, ZW2) and the measured spectrum (GS). A simplified method for determining the concentration of a substance in a sample is thereby provided with which the involvement of an expert in spectral analysis is not necessarily required.

Abstract: A piston for a pretensioner device (10) for a motor vehicle seat belt system of a type having a gas generator (17) with the piston (21) guided in a tube (16) that closes a pressure space (20) in the tube (16). The pressure space (20) can be pressurized by the gas generator (17), driving the piston (21) to undergo pretensioning operation transmitted to the seat belt system by a force transmission means. The piston has a dome shaped front side adapted to engage a force transmission element and a skirt forming a sealing lip oriented toward the pressure space. At least one slot is formed in the outer surface of the piston extending axially from the sealing lip. The slot can be enlarged by the material erosion caused by the pressure and/or pressure conditions in the pressure space produced by gas from the gas generator.

Abstract: A button cell has a winding arranged in the cup-shaped, positive-polarity housing half such that one of the flat end sides points in the direction of the cup base, the circumferential outer side thereof bears against the circumferential cup wall and the outer side together with the cup wall forms a clamping zone in which the first current output conductor is clamped.

Abstract: The present invention provides novel pyrazole derivatives of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.

Abstract: The invention provides certain substituted diazine and triazine compounds of the Formula (I) (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, Rcy, Cy, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.

Abstract: A tensioning device (10) for a seat belt, in particular in a motor vehicle, having a gas generator (17) and a piston (21) guided in a tube (16) that closes a pressure space (20) in the tube (16), whereas the pressure space (20) can be pressurized by the gas generator (17), as a result of which the piston (21) can be driven to perform a tensioning operation which can be transmitted to the seat belt by means of the force transmission means. The piston (21) having a closed or constricted opening (1, 1a), and the opening (1, 1a) can be enlarged and/or opened by the material erosion caused by the pressure and/or pressure conditions in the pressure space (20).