Abstract: A steering handle of a vehicle includes a support structure, which is mounted for rotation about an axis of rotation and at each end of which an angled gripping element for a hand of a driver is provided such that the gripping element can be rotated relative to the support structure. In at least one defined driving state of the vehicle, the two gripping elements are or have been positioned by way of an actuating device in such a way that portions of the gripping elements that are provided for grasping with the hands of the driver lie on a line, the free ends of the portions facing one another.

Abstract: A circuit arrangement includes a preprocessing circuit configured to obtain context information related to a user location, a learning circuit configured to determine a predicted user movement based on context information related to a user location to obtain a predicted route and to determine predicted radio conditions along the predicted route, and a decision circuit configured to, based on the predicted radio conditions, identify one or more first areas expected to have a first type of radio conditions and one or more second areas expected to have a second type of radio conditions different from the first type of radio conditions and to control radio activity while traveling on the predicted route according to the one or more first areas and the one or more second areas.

Abstract: A system and method for an electrically enhanced surgical implant comprising: an implant body that includes an inner frame, wherein the inner frame includes a set electrode sites, and an over-coating that is formed over the inner frame, leaving the electrode sites exposed on the surface of the implant body; a circuitry casing, electrically and mechanically connected to the implant body, implant circuitry, situated at least partially within the implant casing, comprising receiver circuitry, effective to convert an electromagnetic field to electric current, control circuitry, and a power source; a set of conductive paths, wherein each conductive path has a first portion, electrode, situated on an electrode site, and a second portion, electrical conduit, that extends on and through the inner frame and electrically connects the electrode to the implant circuitry in the circuitry casing.

Abstract: A method for forming a flat glass into a glass component, the glass component comprising a base surface and provided with a number of formations for forming surface structural elements that can be felt by a user, is intended to ensure a particularly high mechanical load-bearing capacity of the glass component or moulded part in a particularly simple and reliable manner, even in the case of comparatively complexly configured structural elements. For this purpose, according to the invention, the flat glass is placed in a forming tool on a number of forming plungers corresponding to the intended formations and then heated to soften the material, so that the glass material assumes the contour of the base of the forming tool between the forming plungers for forming the base area.

Abstract: A sensor for determining an air ratio of a fuel gas/air mixture, wherein a housing is formed, which delimitates a measuring space. The housing has on one side a diffusion passage for coupling with a fuel gas/air mixture flow, wherein the diffusion passage is formed by a gas-permeable separating agent. An electrically operated excitation element is arranged for energy supply into the measuring space in order to induce a chemical reaction of a fuel gas/air mixture in the measuring space. At least one optical detection device is directed into the measuring space with its detection area, wherein the at least one optical detection device detects the intensity of radiation from the reaction position in at least a first wavelength range and produces a signal being allocated to the detected intensity, from which the air ratio is inferable.

Abstract: The invention relates to a composite material composed at least of one carrier material, wherein the carrier material is coated on a first surface with a first coating material and on a second surface with a second coating material, wherein the composite material has links of coating material which run from the first surface of the carrier material to the second surface of the carrier material, wherein links of coating material start from 1% to 90% of at least one of the surfaces of the carrier material. The invention further relates to a method for producing a composite material of this type.

Abstract: A fan unit (1), in particular for an air conditioning system of a motor vehicle, comprising an electric motor (2) for driving a fan wheel (3), an electronic device (7) which generates waste heat and provides electrical current to the electric motor (2) and a fan housing (6), wherein the fan wheel (3) is disposed together with the electric motor (2) in an air guiding region (5) delimited by the fan housing (6). Provision is thereby made for the electronic device (7) to be fastened to the side of the fan housing (6) which faces away from the air guiding region (5) in a heat transferring manner so that a heat transfer connection is formed between the electronic device (7) and the air guiding region (5).

Abstract: RNA encoding an immunogen is co-delivered to non-immune cells at the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g. by a single injection.

Abstract: A sensor for determining an air ratio of a fuel gas/air mixture, wherein a housing is formed, which delimitates a measuring space. The housing has on one side a diffusion passage for coupling with a fuel gas/air mixture flow, wherein the diffusion passage is formed by a gas-permeable separating agent. An electrically operated excitation element is arranged for energy supply into the measuring space in order to induce a chemical reaction of a fuel gas/air mixture in the measuring space. At least one optical detection device is directed into the measuring space with its detection area, wherein the at least one optical detection device detects the intensity of radiation from the reaction position in at least a first wavelength range and produces a signal being allocated to the detected intensity, from which the air ratio is inferable.

Abstract: The invention relates to a composite material composed at least of one carrier material, wherein the carrier material is coated on a first surface with a first coating material and on a second surface with a second coating material, wherein the composite material has links of coating material which run from the first surface of the carrier material to the second surface of the carrier material, wherein links of coating material start from 1% to 90% of at least one of the surfaces of the carrier material. The invention further relates to a method for producing a composite material of this type.

Abstract: A composite material includes a carrier material, wherein the carrier material is coated on a first surface with a first coating material and on a second surface with a second coating material, the composite material has links of coating material which run from the first surface of the carrier material to the second surface of the carrier material, and the links of coating material start from 1% to 90% of at least one of the surfaces of the carrier material. A method includes producing a composite material of this type.

Abstract: One aspect of the invention concerns a cosmetic method of treating human skin by delivering an estrogenic component to said skin. The method comprises applying to the skin a composition containing: (i) at least 5 ?g/g of an estrogenic component selected from the group consisting of substances represented by the following formula (I) in which formula R1, R2, R3, R4 independently are a hydrogen atom, a hydroxyl group or an alkoxy group with 1-5 carbon atoms; each of R5, R6, R7 is a hydroxyl group; no more than 3 of R1, R2, R3, R4 are hydrogen atoms; precursors capable of liberating a substance according to the aforementioned formula when used in the present method; and mixtures of one or more of the aforementioned substances and/or precursors; and (ii) a cosmetically acceptable vehicle. Other aspects of the invention relate to therapeutic methods of treating or preventing vaginal dryness or acne and a therapeutic method of promoting wound healing.

Abstract: A composite material includes a carrier material, wherein the carrier material is coated on a first surface with a first coating material and on a second surface with a second coating material, the composite material has links of coating material which run from the first surface of the carrier material to the second surface of the carrier material, and the links of coating material start from 1% to 90% of at least one of the surfaces of the carrier material. A method includes producing a composite material of this type.

Abstract: One aspect of the invention is concerned with a method of hormone replacement therapy, which method comprises administering to a person in need of such a therapy an effective amount of an estrogenic component selected from the group consisting of: substances represented by the formula in which formula R1, R2, R3, R4 independently are a hydrogen atom, a hydroxyl group or an alokxy group with 1-5 carbon atoms; each of R5, R6, R7 is a hydroxyl group; and no more than 3 of R1, R2, R3, R4 are hydrogen atoms; precursors capable of liberating a substance according to the aforementioned formula when used in the present method, and mixtures thereof; said composition containing virtually no progestogen or anti-progestin. Another aspect of the invention relates to a drug delivery system for enteral or parenteral administration that contains at least 1 ?g of the aforementioned estrogenic component and virtually no progestogen or anti-progestin.

Abstract: One aspect of the present invention relates to a method of hormone replacement in mammals, which method comprises the oral administration of an estrogenic component and a progestogenic component to a mammal in an effective amount to prevent or treat symptoms of hypoestrogenism, wherein the estrogenic component is selected from the group consisting of substances represented by the above formula in which formula R1, R2, R3, R4 independently are a hydrogen atom, a hydroxyl group or an alkoxy group with 1-5 carbon atoms; each of R5, R6, R7 is a hydroxyl group; and no more than 3 of R1, R2, R3, R4 are hydrogen atoms; precursors capable of liberating a substance according to the aforementioned formula when used in the present method; and mixtures of one or more of the aforementioned substances and/or precursors.

Abstract: One aspect of the invention concerns a cosmetic method of treating human skin by delivering an estrogenic component to said skin. The method comprises applying to the skin a composition containing: (i) at least 5 ?g/g of an estrogenic component selected from the group consisting of substances represented by the following formula (I) in which formula R1, R2, R3, R4 independently are a hydrogen atom, a hydroxyl group or an alkoxy group with 1-5 carbon atoms; each of R5, R6, R7 is a hydroxyl group; no more than 3 of R1, R2, R3, R4 are hydrogen atoms; precursors capable of liberating a substance according to the aforementioned formula when used in the present method; and mixtures of one or more of the aforementioned substances and/or precursors; and (ii) a cosmetically acceptable vehicle. Other aspects of the invention relate to therapeutic methods of treating or preventing vaginal dryness or acne and a therapeutic method of promoting wound healing.

Abstract: The invention relates to cosmetic methods of treating human skin. The method includes applying to the skin a composition containing an estrogenic component and a cosmetically acceptable vehicle. Other aspects of the invention relate to therapeutic methods of treating or preventing vaginal dryness or acne and a therapeutic method of promoting wound healing. Another aspect relates to a skin care composition comprising the aforementioned estrogenic component and a cosmetically acceptable vehicle.

Abstract: A method of treating or preventing an immune mediated disorder in a mammal, said method comprising the administration of a therapeutically effective amount of an estrogenic component to said mammal, wherein the estrogenic component is selected from the group consisting of: substances represented by the following formula: in which formula R1, R2, R3, R4 independently are a hydrogen atom, a hydroxyl group or an alkoxy group with 1-5 carbon atoms; each of R5, R6, R7 is a hydroxyl group; no more than 3 of R1, R2, R3, R4 are hydrogen atoms; precursors capable of liberating a substance according to the aforementioned formula when used in the present method; and mixtures of one or more of the aforementioned substances and/or precursors. Another aspect of the invention relates to a pharmaceutical formulation comprising the aforementioned estrogenic component, an immunotherapeutic agent and a pharmaceutically acceptable excipient.

Abstract: A method of contraception in mammalian females, which method comprises the parenteral or rectal administration of an estrogenic component and a progestogenic component to a female of childbearing capability in an amount effective to inhibit ovulation, wherein the estrogenic component is selected from the group consisting of substances represented by the following formula (1) in which R1, R2, R3, R4 independently are a hydrogen atom, a hydroxyl group or an alkoxy group with 1-5 carbon atoms; each of R5, R6, R7 is a hydroxyl group; and no more than 3 of R1, R2, R3, R4 are hydrogen atoms; precursors capable of liberating a substance according to the aforementioned formula when used in the present method; and mixtures of one or more of the aforementioned substances and/or precursors.

Abstract: A method of contraception in mammalian females, which method comprises the oral administration of an estrogenic component and a progestogenic component to a female of childbearing capability in an amount effective to inhibit ovulation, wherein the estrogenic component is selected from the group consisting of substances represented by the following formula (1) in which R1, R2, R3, R4 independently are a hydrogen atom, a hydroxyl group or an alkoxy group with 1-5 carbon atoms; each of R5, R6, R7 is a hydroxyl group; and no more than 3 of R1, R2, R3, R4 are hydrogen atoms; precursors capable of liberating a substance according to the aforementioned formula when used in the present method; and mixtures of one or more of the aforementioned substances and/or precursors. Another aspect of the invention concerns a pharmaceutical kit comprising oral dosage units that contain the aforementioned estrogenic component and/or a progestogenic component.