Patents by Inventor Christian Hesslinger

Christian Hesslinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic combinations for the treatment of Progressive Fibrosing interstitial lung diseases
    Publication number: 20230190754
    Abstract: The invention concerns an oral pharmaceutical composition comprising either 18 mg or 9 mg of the PDE4B-inhibitor of formula III a therapeutically effective dose of a second active agent selected from the group consisting of nintedanib or pirfenidone and optionally, one or more pharmaceutically acceptable carriers or excipients for the treatment of a patient suffering from a progressive fibrosing interstitial lung disease (PF-ILD), wherein this oral pharmaceutical composition is to be administered to said patient twice daily.
    Type: Application
    Filed: December 8, 2022
    Publication date: June 22, 2023
    Inventors: Christian HESSLINGER, Verena BAUER, Sebastian Martin BOSSERT, Susan KOBER, Yi LIU, Peter NICKOLAUS, Maria SARNO, Florian VOSS
  • New oral pharmaceutical composition and dose regimen for the therapy of progressive fibrosing interstitial lung diseases
    Publication number: 20230181590
    Abstract: The invention concerns an oral pharmaceutical composition consisting essentially of the PDE4B-inhibitor of formula III in the dose of 18 mg or 9 mg and optionally of one or more pharmaceutically acceptable carriers or excipients for use in the treatment of a patient suffering from one or more progressive fibrosing interstitial lung diseases (PF-ILD), wherein this oral pharmaceutical composition is to be administered to the patient twice daily. The invention further concerns oral pharmaceutical compositions comprising the PDE4B-inhibitor of formula III in the dose of 18 mg or 9 mg and a therapeutically effective dose of a second active ingredient selected from nintedanib or pirfenidone, wherein these oral pharmaceutical compositions are administered to the patient twice daily.
    Type: Application
    Filed: December 8, 2022
    Publication date: June 15, 2023
    Inventors: Christian HESSLINGER, Verena BAUER, Sebastian Martin BOSSERT, Susan KOBER, Yi LIU, Peter NICKOLAUS, Maria SARNO, Florian VOSS
  • Method of treating psoriatic arthritis, psoriasis, and chronic obstructive pulmonary disease with a novel 2,5-substituted pyrimidines
    Patent number: 10391099
    Abstract: The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: August 27, 2019
    Assignee: GRUENENTHAL GMBH
    Inventors: Antonio Nardi, Florian Jakob, Ingo Konetzki, Tobias Craan, Christian Hesslinger
  • Substituted pyrimidine compounds
    Patent number: 10189854
    Abstract: The invention relates to novel substituted pyrimidine compounds of general formula (I) in which the chemical groupings, substituents, variables and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: January 29, 2019
    Assignee: GRUENENTHAL GMBH
    Inventors: Antonio Nardi, Florian Jakob, Ingo Konetzki, Tobias Craan, Christian Hesslinger, Robin Doodeman
  • Substituted condensed pyrimidine compounds
    Patent number: 9688683
    Abstract: Novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: June 27, 2017
    Assignee: GRÜNENTHAL GMBH
    Inventors: Florian Jakob, Ingo Konetzki, Tobias Craan, Antonio Nardi, Christian Hesslinger
  • Substituted condensed pyrimidine compounds
    Patent number: 9670189
    Abstract: The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: June 6, 2017
    Assignee: GRÜNENTHAL GMBH
    Inventors: Ingo Konetzki, Florian Jakob, Tobias Craan, Christian Hesslinger, Paul Ratcliffe, Jason J. Shiers
  • Novel 2,5-substituted pyrimidines
    Publication number: 20170065603
    Abstract: The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Application
    Filed: November 17, 2016
    Publication date: March 9, 2017
    Inventors: Antonio NARDI, Florian JAKOB, Ingo KONETZKI, Tobias CRAAN, Christian HESSLINGER
  • Novel substituted pyrimidine compounds
    Publication number: 20170066776
    Abstract: The invention relates to novel substituted pyrimidine compounds of general formula (I) in which the chemical groupings, substituents, variables and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Application
    Filed: November 17, 2016
    Publication date: March 9, 2017
    Inventors: Antonio NARDI, Florian JAKOB, Ingo KONETZKI, Tobias CRAAN, Christian HESSLINGER, Robin DOODEMAN
  • 2,5-substituted pyrimidines
    Patent number: 9546158
    Abstract: The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: January 17, 2017
    Assignee: GRUENENTHAL GMBH
    Inventors: Antonio Nardi, Florian Jakob, Ingo Konetzki, Tobias Craan, Christian Hesslinger
  • Substituted pyrimidine compounds
    Patent number: 9540349
    Abstract: The invention relates to novel substituted pyrimidine compounds of general formula (I) in which the chemical groupings, substituents, variables and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: January 10, 2017
    Assignee: GRUENENTHAL GMBH
    Inventors: Antonio Nardi, Florian Jakob, Ingo Konetzki, Tobias Craan, Christian Hesslinger
  • Substituted condensed pyrimidine compounds
    Patent number: 9527832
    Abstract: The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: December 27, 2016
    Assignee: GRÜNENTHAL GMBH
    Inventors: Ingo Konetzki, Florian Jakob, Tobias Craan, Christian Hesslinger, Paul Ratcliffe, Antonio Nardi
  • 4-amino substituted condensed pyrimidine compounds as PDE4 inhibitors
    Patent number: 9505724
    Abstract: The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: November 29, 2016
    Assignee: GRÜNENTHAL GMBH
    Inventors: Ingo Konetzki, Florian Jakob, Tobias Craan, Christian Hesslinger
  • NOVEL SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS
    Publication number: 20160152624
    Abstract: Novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Application
    Filed: February 9, 2016
    Publication date: June 2, 2016
    Applicant: GRÜNENTHAL GMBH
    Inventors: Florian JAKOB, Ingo KONETZKI, Tobias CRAAN, Antonio NARDI, Christian HESSLINGER
  • Novel Phthalazinone-Pyrrolopyrimidinecarboxamide Derivatives
    Publication number: 20160108049
    Abstract: The compounds of formula (1), in which R1, R7, R8, R9, R10, R17, R18, R19, R20 and m have the meanings as given in the description, are novel effective inhibitors of type 4 and 5 phosphodiesterase.
    Type: Application
    Filed: December 3, 2015
    Publication date: April 21, 2016
    Inventors: Thomas STENGEL, Thomas MAIER, Alexander MANN, Josef STADLWIESER, Dieter FLOCKERZI, Andreas PAHL, Ewald BENEDIKTUS, Manuela HESSMANN, Tobias KANACHER, Ragna HUSSONG, Christof ZITT, Hans Christof HOLST, Rolf-Peter HUMMEL, Martin VIERTELHAUS, Hermann TENOR, Torsten DUNKERN, Armin HATZELMANN, Christian HESSLINGER
  • 2,5-substituted pyrimidines
    Patent number: 9315490
    Abstract: The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: April 19, 2016
    Assignee: GRUENENTHAL GMBH
    Inventors: Ingo Konetzki, Tobias Craan, Florian Jakob, Antonio Nardi, Christian Hesslinger, Andre Welbers
  • NOVEL SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS
    Publication number: 20160031857
    Abstract: The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Application
    Filed: October 15, 2015
    Publication date: February 4, 2016
    Applicant: GRÜNENTHAL GMBH
    Inventors: Ingo KONETZKI, Florian JAKOB, Tobias CRAAN, Christian HESSLINGER, Paul RATCLIFFE, Antonio NARDI
  • Novel 2,5-Substituted Pyrimidines
    Publication number: 20160024053
    Abstract: The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Application
    Filed: July 15, 2015
    Publication date: January 28, 2016
    Inventors: Ingo KONETZKI, Tobias CRAAN, Florian JAKOB, Antonio NARDI, Christian HESSLINGER, Andre WELBERS
  • Novel 2,5-substituted pyrimidines
    Publication number: 20160016938
    Abstract: The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Application
    Filed: July 15, 2015
    Publication date: January 21, 2016
    Inventors: Antonio NARDI, Florian JAKOB, Ingo KONETZKI, Tobias CRAAN, Christian HESSLINGER
  • Novel substituted pyrimidine compounds
    Publication number: 20160016937
    Abstract: The invention relates to novel substituted pyrimidine compounds of general formula (I) in which the chemical groupings, substituents, variables and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Application
    Filed: July 15, 2015
    Publication date: January 21, 2016
    Inventors: Antonio NARDI, Florian JAKOB, Ingo KONETZKI, Tobias CRAAN, Christian HESSLINGER, Robin DOODEMAN
  • 4-AMINO SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS AS PDE4 INHIBITORS
    Publication number: 20150353507
    Abstract: The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Application
    Filed: August 4, 2015
    Publication date: December 10, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: Ingo KONETZKI, Florian JAKOB, Tobias CRAAN, Christian HESSLINGER