Abstract: Methods for preparing the Bruton's Tyrosine Kinase (“BTK”) inhibitor compound 2-{3?-hydroxymethyl-1-methyl-5-[5-((S)-2-methyl-4-oxetan-3-yl-piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-[3,4?]bipyridinyl-2?-yl}-7,7-dimethyl-3,4,7,8-tetrahydro-2H,6H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one are provided.

Abstract: A package comprising an acoustic device, a polymer frame coupled to the acoustic device, a plurality of frame interconnects located in the polymer frame, where the plurality of frame interconnects are coupled to the acoustic device, a polymer cap layer coupled to the acoustic device though the polymer frame, where the polymer cap layer is configured as a cap for the acoustic device, a plurality of cap interconnects located in the polymer cap layer, where the plurality of cap interconnects are coupled to the plurality of frame interconnects, and a cavity located between the acoustic device and the polymer cap layer. The acoustic device includes a substrate and an acoustic element coupled to the substrate.

Abstract: A machine (1) for processing a liquid food substance includes: a jug (20) having a container (21) and delimiting a food for containing the liquid food substance; and a base (10) that has one or more walls (11) forming a seat (11?) for removably receiving the container (21). The base (10) and/or the container (21) has one or more thermally insulating spacers (11a) spacing the base wall(s) (11) from thermally conditioned outside container wall(s) (21a) when the container (21) is received in or on the seat (11?) so as to prevent or inhibit thermal transfer from the container (21) into the base (10) via the base wall(s) (11) from the container wall(s) (21a) adjacent the base wall(s) (11).

Abstract: An x-ray tube includes a thermionic cathode generating an electron beam propagating from the cathode to a target along a beam axis. The x-ray tube has apertures in the form of a control electrode with a first aperture opening, a focusing electrode with a second aperture opening and a beam shaping electrode with a third aperture opening. The first aperture opening is smaller than the emission surface and has a contour rotationally symmetric with respect to the beam axis. The second aperture opening is larger than the first aperture opening and has a contour rotationally symmetric with respect to the beam axis. The third aperture opening has a contour which is aligned with an xy plane and non-rotationally symmetric with respect to the beam axis. The X-ray tube has a simple structure for generating an electron beam where the number of electrons can be varied easily over a wide range.

Abstract: A skin care composition comprising at least 1 weight % potato protein, a first binding agent, comprising polar or non-polar polymer or co-polymer(s) in an amount of 20-70 weight % and 20-80 weight % of a solid. The skin care composition is capable of interacting with enzymes in stomal output and thereby reducing the enzymatic activity.

Abstract: The disclosure relates to a method for detecting belt slip of a belt drive driving a generator of an internal combustion engine, said belt drive having a belt tensioner that can be adjusted in operation and adjusts the pre-tensioning force of the belt according to the detected belt slip. According to said method, the rotational speed profile of the crankshaft is recorded during an angular window of the crankshaft of m·360 degrees and an average value of the crankshaft rotational speed is formed from said rotational speed profile; temporally independently from the recording of the rotational speed profile of the crankshaft, the rotational speed course of the generator shaft is recorded during an angular window of the generator shaft of n·u?1·360 degrees and an average value of the generator shaft rotational speed is formed from said rotational speed profile.

Abstract: A machine (1) for processing a liquid food substance includes a jug (20) that has a container (21) and a handle (31,32,33) for holding the jug by an adult human hand (40). The container (21) delimits a food cavity (21?) for containing the food substance. The handle (31,32,33) has a connection member (31) projecting from the container (21) and a substantially elongated upright gripping member (32) that is connected to the connection member (31) at a distance from the container (21). The gripping member (32) has an upper portion (32a) that is above the connection member (31) and a lower portion (32b) that is below the connection member (31). The upper portion (32a) is configured to support a thumb (41) of the hand (40) and delimits with the connection member (31) an upper seat (31a) for accommodating an index finger (42) of the hand (40).

Abstract: A machine (1) for processing a liquid food substance includes: a jug (20) having a container (21) and delimiting a food for containing the liquid food substance; and a base (10) that has one or more walls (11) forming a seat (11?) for removably receiving the container (21). The base (10) and/or the container (21) has one or more thermally insulating spacers (11a) spacing the base wall(s) (11) from thermally conditioned outside container wall(s) (21a) when the container (21) is received in or on the seat (11?) so as to prevent or inhibit thermal transfer from the container (21) into the base (10) via the base wall(s) (11) from the container wall(s) (21a) adjacent the base wall(s) (11).

Abstract: A machine (1) for processing a liquid food substance includes: a jug (20) having a container (21) and delimiting a food cavity (21?) for containing the liquid food substance; and a base (10) that has one or more walls (11) forming a seat (11?) for removably receiving the container (21). The base (10) and the jug (20) comprise or delimit, respectively, an off-centred projecting member (33) and a corresponding off-centred seat (13) for the projecting member (33) or vice versa. The off-centred seat (13) is configured to receive the projecting member (33) when the container (21) is received by the base seat (11?) such that the container (21) is in place for processing the liquid food substance. The off-centred projecting member (33) is configured to maintain the container (21) off its place for processing the liquid food substance in the cavity (21?) when the projecting member (33) is off-set relative to the off-centred seat (13).

Abstract: A supplemental device for attachment to an injection device, the supplemental device comprising: an imaging arrangement configured to capture an image of one or more numbers present on a moveable component of the injection device; and a processor arrangement configured to run a first algorithm to: receive data representing an image; determine the position of at least one number in the image by determining the boundaries of each visible number; select one of the visible numbers to be identified; perform a pattern matching process to identify the value of the selected number; and determine a dose dialled into the injection device using the determined position of the selected one of the at least one visible number in the image.

Abstract: A computerized method for providing a service is described. The method may instantiate an instance of a process object. The process object may be configured to manage two or more business process objects of one or more backend systems to provide the service. The service may be performed utilizing the process object.

Abstract: A passive on glass (POG) on filter capping apparatus may include an acoustic filter die. The apparatus may further include a capping die electrically coupled to the acoustic filter die. The capping die may include a 3D inductor.

Abstract: The disclosure relates to a method for detecting belt slip of a belt drive driving a generator of an internal combustion engine, said belt drive having a belt tensioner that can be adjusted in operation and adjusts the pre-tensioning force of the belt according to the detected belt slip. According to said method, the rotational speed profile of the crankshaft is recorded during an angular window of the crankshaft of m·360 degrees and an average value of the crankshaft rotational speed is formed from said rotational speed profile; temporally independently from the recording of the rotational speed profile of the crankshaft, the rotational speed course of the generator shaft is recorded during an angular window of the generator shaft of n·u?1·360 degrees and an average value of the generator shaft rotational speed is formed from said rotational speed profile.

Abstract: A housing for a high voltage tank has a boiler which is open on one side and a circuit board cover which closes the boiler. At least one strain gauge is arranged on or in the circuit board cover such that it is expanded or compressed with a pressure-induced deformation of the circuit board cover. A housing of this type is particularly suited as a high voltage tank for an x-ray emitter. An impermissible pressure in the housing for a high voltage tank can be determined easily and reliably.

Abstract: A passive on glass (POG) on filter capping apparatus may include an acoustic filter die. The apparatus may further include a capping die electrically coupled to the acoustic filter die. The capping die may include a 3D inductor.

Abstract: A heat exchanger with multiple cooling circuits includes fins featuring at least two adjacent areas, a first one of the areas arranged in a first row of pipes and a second one of the areas arranged in a second row of pipes. A number of patterns are arranged in each of the areas. The number of patterns is determined by a specified heat transfer performance requirement for each of the areas.

Abstract: A ceramic material for capacitors using multilayer technology of formula (I): Pb(1?1.5a)AaBb(Zr1?xTix)(1?c?d?e?f)CeSicO3+y·PBO wherein A is selected from the group consisting of La, Nd, Y, Eu, Gd, Tb, Dy, Ho, Er and Yb; C is selected from the group consisting of Ni and Cu; and 0<a<0.12, 0.05?x?0.3, 0?c<0.12, 0.001<e<0.12 and 0?y<1.

Abstract: A process of controlling operation in a multi-cylinder engine either during start of operation or low-load conditions is disclosed. The process may include skipping a supply of fuel in a first set of cylinders of the multi-cylinder engine for a pre-defined number of multiple working cycles. The process may further include supplying fuel-air mixture to a second set of cylinders of the multi-cylinder engine for the pre-defined number of multiple working cycles. The process may also include executing combustion of the fuel-air mixture supplied to the second set of cylinders for the pre-defined number of multiple working cycles. In addition the process may include either changing a selection of cylinders included in the first set of cylinders and the second set of cylinders respectively, or switching the supply of fuel, after the pre-defined number of multiple working cycles, from the second set of cylinders to the first set of cylinders.

Abstract: A device for monitoring the vehicle environment includes: a first sensor for sensing the vehicle environment, the first sensor featuring a first sensing region; a second sensor for sensing the vehicle environment; and an evaluation unit. The second sensor for sensing the vehicle environment is situated within the first sensing region, and a diagnosis of the second sensor is achieved with the aid of the evaluation unit.

Abstract: A supplemental device for attachment to an injection device, the supplemental device comprising: an imaging arrangement configured to capture an image of one or more numbers present on a moveable component of the injection device; and a processor arrangement configured to run a first algorithm to: receive data representing an image; determine the position of at least one number in the image by determining the boundaries of each visible number; select one of the visible numbers to be identified; perform a pattern matching process to identify the value of the selected number; and determine a dose dialled into the injection device using the determined position of the selected one of the at least one visible number in the image.