Abstract: Machine learning is a process that learns a model from a given dataset, where the model can then be used to make a prediction about new data. In order to reduce the costs associated with collecting and labeling real world datasets for use in training the model, computer processes can synthetically generate datasets which simulate real world data. The present disclosure improves the effectiveness of such synthetic datasets for training machine learning models used in real world applications, in particular by generating a synthetic dataset that is specifically targeted to a specified downstream task (e.g. a particular computer vision task, a particular natural language processing task, etc.).

Abstract: Variants of chymosin with improved milk-clotting properties are disclosed.

Abstract: A microstructured optical fiber including a core region and a cladding region which surrounds the core region. The cladding region includes a plurality of cladding features within a cladding background material, wherein the cladding region includes an inner cladding region with at least one inner ring of cladding features and an outer cladding region with at least three outer cladding rings of outer cladding features. The inner cladding features have a first characteristic diameter and the outer cladding region includes a plurality of outer cladding features having a characteristic diameter smaller than the first characteristic diameter. The first characteristic diameter is at least about 10% larger than an average diameter of the outer cladding features and the core region has a diameter of at least about 2 ?m. A cascade optical fiber with at least one fiber as described, as well as a source of optical supercontinuum generation.

Abstract: A microstructured optical fiber having a length and a longitudinal axis along its length, the finer including a core region capable of guiding light along the longitudinal axis and a cladding region which surrounds the core region, the cladding region comprising a cladding background material and a plurality of cladding features within the cladding background material, the cladding features being arranged around the core region, wherein the cladding region comprises an inner cladding region comprising an innermost ring of cladding features and an outer cladding region comprises outer cladding rings of outer cladding features, the innermost ring consisting of those cladding features being closest to the core region, wherein the rings of cladding features each comprise bridges of cladding background material separating adjacent features of the ring, wherein the bridges of the innermost ring have an average minimum width (w1), the minimum width of a bridge of a ring being the shortest distance between two adjace

Abstract: A microstructured optical fiber having a length and a longitudinal axis along its length, the finer including a core region capable of guiding light along the longitudinal axis and a cladding region which surrounds the core region, the cladding region comprising a cladding background material and a plurality of cladding features within the cladding background material, the cladding features being arranged around the core region, wherein the cladding region comprises an inner cladding region comprising an innermost ring of cladding features and an outer cladding region comprises outer cladding rings of outer cladding features, the innermost ring consisting of those cladding features being closest to the core region, wherein the rings of cladding features each comprise bridges of cladding background material separating adjacent features of the ring, wherein the bridges of the innermost ring have an average minimum width (w1), the minimum width of a bridge of a ring being the shortest distance between two adjace

Abstract: A cabin monument arrangement for a passenger cabin of an aircraft, has at least two cabin monuments arranged next to each other, aligned substantially parallel and forming a gap. The gap includes a gap covering in the fastening region of the first lateral monument part and of the second lateral monument part in the region of the front edge portion of the respective cabin monument. In each case, a first contour-adapted rigid fastening strip is on the fastening region and a second contour-adapted, rigid fastening strip is on the second fastening region. A covering element is between the first and second fastening strips for covering the gap between the first monument part and the second monument part, the covering element formed from a flexible covering material of thin design. A corresponding covering of the gap between the cabin monuments can therefore be achieved with sufficient flexibility and material width.

Abstract: The present invention relates to a neutron detector that for the first time permits the construction of large detector areas of approximately 1 m2 to 2 m2, with a spatial resolution of the neutrons of under 2 mm. It is additionally possible in the case of the modular construction in a stack arrangement to attain detection sensitivities that are comparable to 3He counter tubes (ca. 60%) or, with a greater number of detector elements, higher. By using thin substrate plates—such as aluminum sheets—and omission of the external pressure vessels, the neutron detectors are relatively lightweight despite their large dimensions and can be produced inexpensively.

Abstract: The present invention relates to a neutron detector that for the first time permits the construction of large detector areas of approximately 1 m2 to 2 m2, with a spatial resolution of the neutrons of under 2 mm. It is additionally possible in the case of the modular construction in a stack arrangement to attain detection sensitivities that are comparable to 3He counter tubes (ca. 60%) or, with a greater number of detector elements, higher. By using thin substrate plates—such as aluminum sheets—and omission of the external pressure vessels, the neutron detectors are relatively lightweight despite their large dimensions and can be produced inexpensively.

Abstract: A microstructured optical fiber including a core region and a cladding region which surrounds the core region. The cladding region includes a plurality of cladding features within a cladding background material, wherein the cladding region includes an inner cladding region with at least one inner ring of cladding features and an outer cladding region with outer cladding rings of outer cladding features. The inner cladding features have a first characteristic diameter and the outer cladding region includes a plurality of outer cladding features having a characteristic diameter smaller than the first characteristic diameter. The core region has a diameter of at least about 2 ?m. A cascade optical fiber with at least one fiber as described, as well as a source of optical supercontinuum generation.

Abstract: The present invention lies in the field of visualization and quantification of immobilized targets in samples using immunochemical means. In particular, the invention relates to a method and reagents for detection, visualization and quantification of a molecular target in immunosiained histological samples using particular compositions of the target specific binding agent. Methods and compositions of the invention are suitable for any assay that uses a target visualization system in histological samples based on detection of the target by the target specific binding agent. The methods and compositions tire useful for evaluation of targets that are biomarkers of diseases in medical diagnostic.

Abstract: A microstructured optical fiber including a core region and a cladding region which surrounds the core region. The cladding region includes a plurality of cladding features within a cladding background material, wherein the cladding region includes an inner cladding region with at least one inner ring of cladding features and an outer cladding region with at least three outer cladding rings of outer cladding features. The inner cladding features have a first characteristic diameter and the outer cladding region includes a plurality of outer cladding features having a characteristic diameter smaller than the first characteristic diameter. The first characteristic diameter is at least about 10% larger than an average diameter of the outer cladding features and the core region has a diameter of at least about 2 ?m. A cascade optical fiber with at least one fiber as described, as well as a source of optical supercontinuum generation.

Abstract: The present invention lies in the field of visualization and quantification of immobilized targets in samples using immunochemical means. In particular, the invention relates to a method and reagents for detection, visualization and quantification of a molecular target in immunostained histological samples using particular compositions of the target specific binding agent. Methods and compositions of the invention are suitable for any assay that uses a target visualization system in histological samples based on detection of the target by the target specific binding agent. The methods and compositions are useful for evaluation of targets that are biomarkers of diseases in medical diagnostic.

Abstract: A microstructured optical fiber including a core region and a cladding region which surrounds the core region. The cladding region includes a plurality of cladding features within a cladding background material, wherein the cladding region includes an inner cladding region with at least one inner ring of cladding features and an outer cladding region with at least three outer cladding rings of outer cladding features. The inner cladding features have a first characteristic diameter and the outer cladding region includes a plurality of outer cladding features having a characteristic diameter smaller than the first characteristic diameter. The first characteristic diameter is at least about 10% larger than an average diameter of the outer cladding features and the core region has a diameter of at least about 2 ?m. A cascade optical fiber with at least one fiber as described, as well as a source of optical supercontinuum generation.

Abstract: A cabin monument arrangement for a passenger cabin of an aircraft, has at least two cabin monuments arranged next to each other, aligned substantially parallel and forming a gap. The gap includes a gap covering in the fastening region of the first lateral monument part and of the second lateral monument part in the region of the front edge portion of the respective cabin monument. In each case, a first contour-adapted rigid fastening strip is on the fastening region and a second contour-adapted, rigid fastening strip is on the second fastening region. A covering element is between the first and second fastening strips for covering the gap between the first monument part and the second monument part, the covering element formed from a flexible covering material of thin design. A corresponding covering of the gap between the cabin monuments can therefore be achieved with sufficient flexibility and material width.

Abstract: A microstructured optical fiber includes a core region and a cladding region which surrounds the core region. The cladding region includes a plurality of cladding features within a cladding background material, wherein the cladding region includes an inner cladding region with at least one inner ring of cladding features and an outer cladding region with at least three outer cladding rings of outer cladding features. The inner cladding features have a first characteristic diameter and the outer cladding region includes a plurality of outer cladding features having a characteristic diameter smaller than the first characteristic diameter. The first characteristic diameter is at least about 10% larger than an average diameter of the outer cladding features and the core region has a diameter of at least about 2 ?m.

Abstract: A microstructured optical fiber includes a core region and a cladding region which surrounds the core region. The cladding region includes a plurality of cladding features within a cladding background material, wherein the cladding region includes an inner cladding region with at least one inner ring of cladding features and an outer cladding region with at least three outer cladding rings of outer cladding features. The inner cladding features have a first characteristic diameter and the outer cladding region includes a plurality of outer cladding features having a characteristic diameter smaller than the first characteristic diameter. The first characteristic diameter is at least about 10% larger than an average diameter of the outer cladding features and the core region has a diameter of at least about 2 ?m.

Abstract: The invention relates to a tapered optical fiber and a method and drawing tower for producing such an optical fiber. The tapered optical fiber comprising a core region that is capable of guiding light along a longitudinal axis of said optical fiber and a cladding region surrounding said core region. The optical fiber comprises a tapered section arranged between a first longitudinal position and a second longitudinal position, said tapered section comprising a first taper section having a first length, L1, over which the optical fiber is tapered down to a taper waist, and a second taper section having a second length, L2, over which said optical fiber is tapered up.

Abstract: The present invention lies in the field of visualization and quantification of immobilized targets in samples using immunochemical means. In particular, the invention relates to a method and reagents for detection, visualization and quantification of a molecular target in immunostained histological samples using particular compositions of the target specific binding agent. Methods and compositions of the invention are suitable for any assay that uses a target visualization system in histological samples based on detection of the target by the target specific binding agent. The methods and compositions are useful for evaluation of targets that are biomarkers of diseases in medical diagnostic.

Abstract: The invention relates to a tapered optical fiber and a method and drawing tower for producing such an optical fiber. The tapered optical fiber comprising a core region that is capable of guiding light along a longitudinal axis of said optical fiber and a cladding region surrounding said core region. The optical fiber comprises a tapered section arranged between a first longitudinal position and a second longitudinal position, said tapered section comprising a first taper section having a first length, L1, over which the optical fiber is tapered down to a taper waist, and a second taper section having a second length, L2, over which said optical fiber is tapered up.

Abstract: A method of making a preform for an optical fiber includes the steps of providing at least one rod shaped unit having an outer surface of glass, subjecting the at least one rod shaped unit to a laser surface treatment by directing a laser beam onto its outer surface to thereby evaporate glass from the surface, while simultaneously providing a gas flow to thereby remove the evaporated glass, and applying the treated rod shaped unit in intimate contact with a second unit so that at least a part of the surface of the rod shaped unit that has been subjected to a laser surface treatment is in intimate contact with the second unit.