Abstract: The present invention relates to an insert (5) for a tube (1) for dispensing liquid content in the form of drops, wherein the insert (5) comprises at least one notch (16; 17) at its outer wall, with the notch (16; 17) extending in the longitudinal direction, wherein the insert (5) is provided with an annular indentation (10), the annular indentation (10) dividing the insert into a proximal part (7) and a distal part (8) that are connected by a shaft (9), wherein both the proximal part (7) and the distal part (8) comprise a notch (16; 18) extending in the longitudinal direction on the respective outer wall, and wherein the outer diameter of the proximal part (7) and the outer diameter of the distal part (8) of the insert (5) are such that they match the inner diameter of a spout (2) of a tube (1), into which the insert (5) shall be placed. The invention further relates to a tube (1) with such an insert (5).

Abstract: The disclosure relates to tube with a tube head (4) and a container (5) made of resilient material, wherein the tube head (4) is connected to the container (5), wherein the tube head (4) comprises a female Luer lock fitting (7) with a flow passage (17), the female Luer lock fitting (7) being designed for sealingly receiving a male Luer lock fitting (9) of a syringe (2), wherein a tamper-evident closure (11, 12, 13, 14) is arranged at the inner surface of the female Luer lock fitting (7) such that it closes the flow passage (17) in a closed state of the tube (1).

Abstract: The present invention relates to an insert (5) for a tube (1) for dispensing liquid content in the form of drops, wherein the insert (5) comprises at least one notch (16; 17) at its outer wall, with the notch (16; 17) extending in the longitudinal direction, wherein the insert (5) is provided with an annular indentation (10), the annular indentation (10) dividing the insert into a proximal part (7) and a distal part (8) that are connected by a shaft (9), wherein both the proximal part (7) and the distal part (8) comprise a notch (16; 18) extending in the longitudinal direction on the respective outer wall, and wherein the outer diameter of the proximal part (7) and the outer diameter of the distal part (8) of the insert (5) are such that they match the inner diameter of a spout (2) of a tube (1), into which the insert (5) shall be placed. The invention further relates to a tube (1) with such an insert (5).

Abstract: The invention relates to a one-way valve (1; 1?) for discharge regulation of a tube, the one-way valve (1; 1?) comprising a sealing means (9) and a ring support (8), with the sealing means (9) being at least partially inserted in the ring support (8), wherein the sealing means (9) comprises a sealing element (11) and a support element (12) that has at least one opening (10), wherein the sealing element (11) is connected to the support element (12) by anchoring means (13) and rests on the ring support (12) in a closed state of the one-way valve (1; 1?) thereby covering the at least one opening (10), and wherein the sealing element (11) is of lower bending stiffness than the support element (12) and the ring support (8). The invention furthermore relates to a tube with a tube head (2; 2?) and a container (6), wherein such a one-way valve (1; 1?) is inserted in the neck (4) of the tube head (2; 2?). Moreover the invention relates to a method for manufacturing such a one-way valve (1; 1?).

Abstract: The disclosure relates to tube with a tube head (4) and a container (5) made of resilient material, wherein the tube head (4) is connected to the container (5), wherein the tube head (4) comprises a female Luer lock fitting (7) with a flow passage (17), the female Luer lock fitting (7) being designed for sealingly receiving a male Luer lock fitting (9) of a syringe (2), wherein a tamper-evident closure (11; 12, 13, 14) is arranged at the inner surface of the female Luer lock fitting (7) such that it closes the flow passage (17) in a closed state of the tube (1).

Abstract: The invention relates to a one-way valve (1; 1?) for discharge regulation of a tube, the one-way valve (1; 1?) comprising a sealing means (9) and a ring support (8), with the sealing means (9) being at least partially inserted in the ring support (8), wherein the sealing means (9) comprises a sealing element (11) and a support element (12) that has at least one opening (10), wherein the sealing element (11) is connected to the support element (12) by anchoring means (13) and rests on the ring support (12) in a closed state of the one-way valve (1; 1?) thereby covering the at least one opening (10), and wherein the sealing element (11) is of lower bending stiffness than the support element (12) and the ring support (8). The invention furthermore relates to a tube with a tube head (2; 2?) and a container (6), wherein such a one-way valve (1; 1?) is inserted in the neck (4) of the tube head (2; 2?). Moreover the invention relates to a method for manufacturing such a one-way valve (1; 1?).