Abstract: A system identifies or screens one or more biological materials. The system includes at least one bioreactor adapted to provide biological samples and an automated sample handler comprising at least one bi-directional pump to transport biological samples, reagents and fluids, at least one reaction chamber with at least two regions separated by a semi-permeable membrane and fitted with a thermoelectric module for cooling and heating the chamber. At least one multi-positional valve directs transport of the biological samples, reagents and fluids into and out of the reaction chamber and a micro-processor to control operations of the sample handler. A detector is used to identify the biological material in the samples and a sample repository collects the identified biological samples.