Abstract: Imidazole-substituted 4-anilino-3-cyanoquinolines are described, which selectively inhibit IFGR kinase activity and are useful for treating disorders associated with IGFR kinases.

Abstract: Compounds of Formula (I), are provided where T is CHO, COR8, or C(OH)R1R2; R1 and R2 are hydrogen, optionally substituted lower alkyl, CF3, optionally substituted alkenyl, or optionally substituted alkynyl; R3 is hydrogen or optionally substituted lower alkyl; R4 is (CF3)nalkyl, (CF3)n(substitutedalkyl), (CF3)nalkylphenyl, (CF3)nalkyl(substitutedphenyl), or (F)ncycloalkyl; n=1-3; R5 is hydrogen, halogen, CF3, diene fused to Y when Y=C, or substituted diene fused to Y when Y=C; W, Y and Z are C, CR6 or N where at least one of W, Y or Z are C; R6 is hydrogen, halogen, or optionally substituted lower alkyl; X is O, S, SO2, or NR7; R7 is hydrogen, optionally substituted lower alkyl, optionally substituted benzyl, or optionally substituted phenyl; and R8 is lower alkyl, CF3, or optionally substituted phenyl. Methods of preparing and using these compounds for inhibiting beta amyloid production and for treatment of Alzheimer's Disease and Down's syndrome are also described.

Abstract: The invention relates to a seal, which is disposed at a vertical frame profile of a stationary door leaf or of a movable door leaf and has a sealing profile protruding from the frame profile and a deformation chamber extending in longitudinal direction of the sealing profile. The invention concentrates on the fact that a part of the sealing profile protruding from the front side of the frame profile in cross-section forms the portion (T) of an ellipse or substantially of an ellipse, the minor axis (N) of the ellipse intersecting the wall of the sealing profile outside the frame profile.

Abstract: Compounds of Formula (I), are provided where T is CHO, COR8, or C(OH)R1R2; R1 and R2 are hydrogen, optionally substituted lower alkyl, CF3, optionally substituted alkenyl, or optionally substituted alkynyl; R3 is hydrogen or optionally substituted lower alkyl; R4 is (CF3)nalkyl, (CF3)n(substituted alkyl), (CF3)nalkylphenyl, (CF3)nalkyl(substituted phenyl), or (F)ncycloalkyl; n=1-3; R5 is hydrogen, halogen, CF3, diene fused to Y when Y?C, or substituted diene fused to Y when Y?C; W, Y and Z are C, CR6 or N where at least one of W, Y or Z are C; R6 is hydrogen, halogen, or optionally substituted lower alkyl; X is O, S, SO2, or NR7; R7 is hydrogen, optionally substituted lower alkyl, optionally substituted benzyl, or optionally substituted phenyl; and R8 is lower alkyl, CF3, or optionally substituted phenyl. Methods of preparing and using these compounds for inhibiting beta amyloid production and for treatment of Alzheimer's Disease and Down's syndrome are also described.

Abstract: The present invention relates generally to substituted heteroaryl benzofuran acids and methods of using them.

Abstract: A polar modulator contains a first input for supplying an amplitude modulation word and a second input for supplying a phase modulation word. The first input is connected to a first signal path, and the second input is connected to a second signal path. The polar modulator contains a converter having a first input which is connected to a first signal path and having a second input which is connected to the second signal path. In this case, the converter is configured to output a radio-frequency signal derived from the phase modulation word and the amplitude modulation word. A feedback path has a level detector connected to the converter and has its output side connected to a correction device. The correction device is designed to output a correction word to the first signal path on the basis of a signal which is output by the level detector.

Abstract: The present invention relates generally to substituted heteroaryl benzofuran acids and methods of using them.

Abstract: This invention provides PAI-1 inhibiting compounds of Formula I: wherein: R1, R2, R3, and R4 are each H, alkyl, , alkanoyl, halo, OH, aryl optionally substituted with R8, perfluoroalkyl, alkoxy, amino, alkylamino, dialkylamino, pertluoroalkoxy; R5 is H, alkyl, perfluoroalkyl, aryl optionally substituted with R5, alkanoyl, aroyl optionally substituted with R8; R6 is H, alkyl, alkylaryl, benzyl optionally substituted with R8, alkanoyl, aroyl optionally substituted with R8; R7 is H, alkyl, alkylaryl, aryl optionally substituted with R8; n is 0-6; A is COOH, or an acid mimic such as tetraazole, SO3H, PO3H2, tetronic acid, etc.; R8 is H, alkyl, cycloalkyl, alkanoyl, halo, OH, perfluoroalkyl, alkoxy, amino, alkylamino, dialkylamino, perfluoroalkoxy; or a pharmaceutically acceptable salt thereof; as well as pharmaceutical compositions and methods of treatment using these compounds.

Abstract: Vehicle seat which effects a sideways movement of the occupant sitting on the vehicle seat during a lateral impact or directly before a lateral impact. The sideways movement takes place away from the side of the vehicle which faces the impact and toward the center of the vehicle, at least one seat cushion being transversely displaceable separately in relation to the seat components and in relation to the seat fixing elements for the sideways movement.

Abstract: This invention provides PAI-1 inhibiting compounds of Formula I: wherein: R1, R2, R3, and R4 are each H, alkyl, alkanoyl, halo, OH, aryl optionally substituted with R8, perfluoroalkyl, alkoxy, amino, alkylamino, dialkylamino, perfluoroalkoxy; R5 is H, alkyl, perfluoroalkyl, aryl optionally substituted with R8, alkanoyl, aroyl optionally substituted with R8; R6 is H, alkyl, alkylaryl, benzyl optionally substituted with R8, alkanoyl, aroyl optionally substituted with R8; R7 is H, alkyl, alkylaryl, aryl optionally substituted with R8; n is 0-6; A is COOH, or an acid mimic such as tetraazole, SO3H, PO3H2, tetronic acid, etc.; R8 is H, alkyl, cycloalkyl, alkanoyl, halo, OH, perfluoroalkyl, alkoxy, amino, alkylamino, dialkylamino, perfluoroalkoxy; or a pharmaceutically acceptable salt thereof; as well as pharmaceutical compositions and methods of treatment using these compounds.

Abstract: A belt tensioning unit has a reversible clamping device which is controlled by a sensor system which is capable of recognizing potentially dangerous or accident-prone driving situations. In the event of danger, the belt is tensioned with sufficient force in order to draw the occupant into a desired sitting position prior to a possible collision or to retain the occupant in this position.

Abstract: Compounds of Formula (I), are provided where T is CHO, CON, or C(OH)R1R2; R1 and R2 are hydrogen, optionally substituted lower alkyl, CF3, optionally substituted alkenyl, or optionally substituted alkynyl; R3 is hydrogen or optionally substituted lower alkyl; R4 is (CF3)nalkyl, (CF3)n(substitutedalkyl), (CF3)nalkylphenyl, (CF3)nalkyl(substitutedphenyl), or (F)ncycloalkyl; n=1-3; R5 is hydrogen, halogen, CF3, diene fused to Y when Y?C, or substituted diene fused to Y when Y?C; W, Y and Z are C, CR6 or N where at least one of W, Y or Z are C; R6 is hydrogen, halogen, or optionally substituted lower alkyl; X is O, S, SO2, or NR7; R7 is hydrogen, optionally substituted lower alkyl, optionally substituted benzyl, or optionally substituted phenyl; and R8 is lower alkyl, CF3, or optionally substituted phenyl. Methods of preparing and using these compounds for inhibiting beta amyloid production and for treatment of Alzheimer's Disease and Down's syndrome are also described.

Abstract: A utility vehicle has an electronically controlled drive train which has at least one drive unit, one steering system and one braking system. In addition, the motor vehicle has a maneuvering assistance system with a display device, an input device and a control system. The display device displays an actual orientation and an actual position of the vehicle as well as the relatively close surroundings of the vehicle on a monitor. The input device inputs a desired orientation and a desired position for the vehicle. The control system processes a maneuvering algorithm and at the same time actuates the drive train to transfer the vehicle from its actual orientation and actual position into its desired orientation and desired position taking into account the vehicle surroundings.

Abstract: The present invention relates to a control system (7) for a vehicle combination composed of a towing vehicle and a trailer for picking up, transporting and setting down a frame which can be positioned on supports and have a payload loaded onto it, wherein a path computer (8) is provided which calculates a path which, in order to pick up the frame (4) calculates a path which leads the trailer backward under the frame. A particularly reliable system is obtained if a first input device (10) is provided, by means of which an actual position and an actual orientation of the frame can be input into the path computer (8), and if a second input device (11) is provided by means of which an actual position and an actual orientation of the trailer can be input into the path computer (8).

Abstract: This invention provides smooth muscle cell proliferation inhibitors of formula I having the structure

Abstract: A motor vehicle body includes a support structure made of large-sized partial modules. A roof module has front and rear roof columns placed onto a basic module approximately level with a side wall edge of the body, and the front and rear roof columns of the roof module are connected to one another via a respectively assigned cross member. In order to provide a support structure having a basic module for different roof structures, and to make the support structure very stiff with the roof module, the rear roof columns are connected to each other via a supporting plate of a rear parcel shelf which is stiffened by the assigned cross member.

Abstract: A safety device for, in particular, nonrailborne vehicles, having a monitoring device to monitor a hazardous area and additionally the road area, located on the opposite side of the hazardous area viewed from the vehicle and adjoining the hazardous area. Obstacles in the hazardous area and/or road area are detected. An output signal is brought about if an obstacle which prevents the hazardous area being traveled through completely has been detected.

Abstract: A motor vehicle body, having a roof module which is placed onto a support structure and is adjoined by a lid (engine hood) for closing a space (engine compartment on an end region of the body, the lid being held on the body via a bearing arrangement in the vicinity of the roof module. In order to position the lid in relation to the adjacent roof module with relatively little technical outlay, the bearing arrangement is arranged directly on the roof module and can therefore already be prefitted to the roof module before the roof module is placed onto the support structure.

Abstract: A transmitter includes a transformer that is configured to transform a baseband signal into an amplitude information signal and a phase information signal. The transmitter includes a ramping control unit configured to generate a power control signal. The transmitter includes a mixer that is configured to combine the amplitude information signal with the power control signal and produce a second amplitude information signal. The transmitter includes a modulator that is configured to modulate the second amplitude information signal on the phase information signal and produce an output signal.

Abstract: The invention relates to a hazard-prevention system for a vehicle. The vehicle has devices for sensing driving state variables, for sensing ambient data and for sensing the driver's activity, and a data processing device. The data processing device is provided for processing the sensed data and for actuating a safety device in accordance with a predefined control strategy. According to the invention, the vehicle has a device for identifying the driver, and the data processing device derives a driver load factor related specifically to the driver from the driving state variables, the ambient data and the data relating to the activity of the driver, and said driver load factor is used to adapt the control strategy.