Abstract: Provided herein are heterocyclic compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. The subject compounds and compositions are useful for the treatment of bacterial infections, such as pneumonia.

Abstract: Provided herein are heterocyclic compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. The subject compounds and compositions are useful for the treatment of bacterial infections, such as pneumonia.

Abstract: Described herein are compounds that are glutaminyl-peptide cyclotransferase like (QPCTL) protein modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of QPCTL activity.

Abstract: Techniques are disclosed for accurately identifying distinct physical user devices in a cross-device context. An example embodiment applies a multi-phase approach to generate labeled training datasets from a corpus of unlabeled device records. Such labeled training datasets can be used for training machine learning systems to predict the occurrence of device records that have been wrongly (or correctly, as the case may be) attributed to different physical user devices. Such identification of improper attribution can be particularly helpful in web-based analytics. The labeled training datasets include labeled pairs of device records generated using multiple strategies for inferring whether the two device records of a pair of device records represent the same physical user device (or different physical user devices). The labeled pairs of device records can then be used to train classifiers to predict with confidence whether two device records represent or do not represent the same physical user device.

Abstract: Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. Furthermore, the subject compounds and compositions are useful for the treatment of bacterial infection, such as urinary tract infection and the like.

Abstract: Provided herein are heterocyclic derivative compounds of Formula (II), and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. Furthermore, the subject compounds and compositions are useful for the treatment of bacterial infection, such as urinary tract infection and the like.

Abstract: Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. Furthermore, the subject compounds and compositions are useful for the treatment of bacterial infection, such as urinary tract infection and the like.

Abstract: Techniques are disclosed for accurately identifying distinct physical user devices in a cross-device context. An example embodiment applies a multi-phase approach to generate labeled training datasets from a corpus of unlabeled device records. Such labeled training datasets can be used for training machine learning systems to predict the occurrence of device records that have been wrongly (or correctly, as the case may be) attributed to different physical user devices. Such identification of improper attribution can be particularly helpful in web-based analytics. The labeled training datasets include labeled pairs of device records generated using multiple strategies for inferring whether the two device records of a pair of device records represent the same physical user device (or different physical user devices). The labeled pairs of device records can then be used to train classifiers to predict with confidence whether two device records represent or do not represent the same physical user device.

Abstract: Candidate compounds for specific inhibition of Rpn11 are represented by Formula 1a where each of R2, R3, R4, R5, R6, and R7 is independently selected from hydrogen (H), substituted and unsubstituted alkyl groups, carboxyl groups, or substituted and unsubstituted carboxyamides.

Abstract: Provided herein, inter alia, are compounds and methods for treating infectious diseases. The compounds provided herein are, inter alia, useful for the treatment of bacterial infections. The compounds provided herein are, inter alia, useful inhibitors of metalloproteins, e.g. UDP-3-O—(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC).

Abstract: Provided herein are ROS-sensitive prodrug compositions and methods of treating ROS-associated diseases by administering the ROS-sensitive prodrug compositions.

Abstract: Candidate compounds for specific inhibition of Rpn11 are represented by Formula 1a where each of R2, R3, R4, R5, R6, and R7 is independently selected from hydrogen (H), substituted and unsubstituted alkyl groups, carboxyl groups, or substituted and unsubstituted carboxyamides.

Abstract: Provided herein are ROS-sensitive prodrug compositions and methods of treating ROS-associated diseases by administering the ROS-sensitive prodrug compositions.

Abstract: The invention relates to the preparation of a catalytic composition that comprises a carbonated structuring material (MSC) associated with a catalyst (CAT). The invention comprises mixing a solution of a first solvent (SOL1) including the carbonated structuring material (MSC) and a solution of a second solvent (SOL2) including the catalyst (CAT), and agitating (AGM) the resulting mixture up to the precipitation if the catalyst on the carbonated structuring material. According to one aspect, the catalyst and the structuring material are not soluble in the mixture of the first and second solvents. The composition thus obtained can be used after filtration as a material for an electrode in a fuel cell.

Abstract: The present invention relates to a device for measuring the concentration of hydrogen in a gaseous mixture and in particular in the air constituting, for example, the atmosphere inside a closed premises. This device comprises a sensor in contact with a gaseous mixture, the sensor being linked to calculating and display function. The sensor comprises a catalyst capable of provoking an exothermic reaction with the hydrogen contained in the gaseous mixture, a conducting function fixed to the catalyst for transferring essentially by conduction the thermal energy release by the reaction from the catalyst to a cold point, a function for measuring the temperature T1 of the catalyst and the temperature T2 of the cold point being linked to the function for calculating the value of the molar concentration of hydrogen in a gaseous mixture from the temperature gradient measured T1-T2.