Patents by Inventor Christina Li Lin Chai
Christina Li Lin Chai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10865384Abstract: This invention relates to a method for inducing or enhancing the differentiation of pluripotent stem cells into cardiomyocyte via casein kinase 1 inhibition said method comprising culturing the stem cells in the presence of a medium comprising a casein kinase 1 inhibitor of the formula (I) or (II) or a stereoisomer, tautomer, or a salt thereof wherein R1, R2 and R3 independently from another represent hydrogen, optionally substituted alkyl, alkenyl, alkynyl, heterocyclyl, heteroaryl or aryl; X represents NR4, O or S; and R4 represents hydrogen, optionally substituted alkyl, alkenyl, alkynyl, heterocyclyl, heteroaryl or aryl. The method can be used in the late phase of stem cell differentiation and in the compounds of formula (I) or (II) in combination with other small molecules can lead to especially high differentiation of stem cells into cardiomyocytes. The invention further relates to novel compounds which can be used in the method of the invention and kits for stem cell differentiation.Type: GrantFiled: February 6, 2015Date of Patent: December 15, 2020Assignees: Agency for Science, Technology and Research, National University of SingaporeInventors: Filip Laco, Joo Leng Low, Steve Oh, Christina Li Lin Chai, Qixing Zhong
-
Publication number: 20200061579Abstract: Disclosed herein is a method of manufacturing molecularly imprinted polymers for scarce target molecules that are made using surrogate molecules. Also disclosed herein are the molecularly imprinted polymers and their use in detecting the selected target molecules, particularly through the binding of a fluorescent surrogate molecule to the molecularly imprinted polymers that is then displaced from the molecularly imprinted polymer upon contact with the target molecule.Type: ApplicationFiled: May 16, 2018Publication date: February 27, 2020Inventors: Christina Li Lin CHAI, Yen Wah TONG, Chee Yew LEONG, Cheng LI, Mun Hong NGAI
-
Publication number: 20190359941Abstract: The present invention relates to substituted azole derivatives in combination with cytokines in the ex vivo expansion of CD34+ hematopoietic stem and progenitor cells (HSPC) in a biological sample, more particularly the expansion of these cells obtained from non-enriched, i.e., the mononuclear fraction of the biological sample. The present invention further describes the transplantation regimen of the expanded hematopoietic graft developed through xenotransplantation studies. In a preferred embodiment, the combination comprising the azole based compounds and cytokines selected from SCF, TPO, FLT-3L and IGFBP-2 and results in the expansion of expansion of CD45+CD34+CD38?CD45RA?CD90+ hematopoietic stem cells and/or CD45+CD34+CD38?CD45RA?CD90+CD49f+ hematopoietic stem cells and/or CD45+CD34+CD38?CD45RA? hematopoietic progenitor cells from the mononucleated cells isolated from umbilical cord blood.Type: ApplicationFiled: August 18, 2017Publication date: November 28, 2019Applicants: National University of Singapore, Singapore Health Services Pte LtdInventors: Sudipto BARI, Christina Li Lin CHAI, Gigi Ngar Chee CHIU, William Ying Khee HWANG, Joo Leng LOW, Qixing ZHONG
-
Patent number: 9938415Abstract: The present invention relates to derivatives of ?, ?-disubstituted amide compounds which comprise a substituted aryl at the ? carbon such that the substituent provides a means for attachment or incorporation of the compound to or in a polymer. The provision of such a substituent on the aryl has surprisingly been found not only to permit attachment to or incorporation n a polymer but also retention of useful antifouling activity. In embodiments, the substituent is selected from hydroxyl, ethers, esters, carboxyls, alkylsilyls and alkenyls. Experiments demonstrate that antifouling activity can be as good or better as the corresponding unsubstituted compound and that polymers functionalized so as to include or be formed from the substituted compound can be used to reduce settlement.Type: GrantFiled: September 21, 2015Date of Patent: April 10, 2018Assignees: Agency for Science, Technology and Research, National University of Singapore, Maritime and Port Authority of SingaporeInventors: Christina Li Lin Chai, Brendan Adrian Burkett, Serena Lay Ming Teo, Daniel Rittschof, Serina Siew Chen Lee, Gary Howard Dickinson, Han Hong
-
Publication number: 20170166867Abstract: This invention relates to a method for inducing or enhancing the differentiation of pluripotent stem cells into cardiomyocyte via casein kinase 1 inhibition said method comprising culturing the stem cells in the presence of a medium comprising a casein kinase 1 inhibitor of the formula (I) or (II) or a stereoisomer, tautomer, or a salt thereof wherein R1, R2 and R3 independently from another represent hydrogen, optionally substituted alkyl, alkenyl, alkynyl, heterocyclyl, heteroaryl or aryl; X represents NR4, O or S; and R4 represents hydrogen, optionally substituted alkyl, alkenyl, alkynyl, heterocyclyl, heteroaryl or aryl. The method can be used in the late phase of stem cell differentiation and in the compounds of formula (I) or (II) in combination with other small molecules can lead to especially high differentiation of stem cells into cardiomyocytes. The invention further relates to novel compounds which can be used in the method of the invention and kits for stem cell differentiation.Type: ApplicationFiled: February 6, 2015Publication date: June 15, 2017Inventors: Filip LACO, Joo Leng LOW, Steve OH, Christina Li Lin CHAI, Qixing ZHONG
-
Patent number: 9441134Abstract: Disclosed is a process for preparing fluorinated core-shell polymer particles in which the core is a non-fluorinated polymer and the shell is derived from at least 50% by weight of fluorinated monomers, by 1) synthesizing a core polymer latex by aqueous emulsion polymerization of non-fluorinated monomers forming the core polymer, 2) adding the shell-forming fluorinated monomers or mixtures of at least 50% by weight of fluorinated monomers with non-fluorinated monomers to the core polymer latex of step 1) and allowing for at least one hour of equilibration time in which essentially no polymerization of the shell monomers occurs, 3) reacting the shell-forming monomers in the mixture from step 2) to form the core-shell polymer particles, wherein the process steps 1) to 3) are carried out under mechanical stirring in the absence of surfactants, emulsifiers, emulsifying monomers and mixtures thereof.Type: GrantFiled: June 2, 2010Date of Patent: September 13, 2016Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Parappuveetil Sarangadharan Suresh, Yoong Kim, Andreas Fechtenkotter, Han Hong, Christina Li Lin Chai, Xiaogang Yang, Yeap Hung Ng
-
Publication number: 20160009926Abstract: The present invention relates to derivatives of ?, ?-disubstituted amide compounds which comprise a substituted aryl at the a carbon such that the substituent provides a means for attachment or incorporation of the compound to or in a polymer. The provision of such a substituent on the aryl has surprisingly been found not only to permit attachment to or incorporation n a polymer but also retention of useful antifouling activity. In embodiments, the substituent is selected from hydroxyl, ethers, esters, carboxyls, alkylsilyls and alkenyls. Experiments demonstrate that antifouling activity can be as good or better as the corresponding unsubstituted compound and that polymers functionalised so as to include or be formed from the substituted compound can be used to reduce settlement.Type: ApplicationFiled: September 21, 2015Publication date: January 14, 2016Inventors: Christina Li Lin Chai, Brendan Adrian Burkett, Serena Lay Ming Teo, Daniel Rittschof, Serina Siew Chen Lee, Gary Howard Dickinson, Han Hong
-
Patent number: 9169223Abstract: The present invention relates to derivatives of ?,?-disubstituted amide compounds which comprise a substituted aryl at the ? carbon such that the substituent provides a means for attachment or incorporation of the compound to or in a polymer. The provision of such a substituent on the aryl has surprisingly been found not only to permit attachment to or incorporation in a polymer but also retention of useful antifouling activity. In embodiments, the substituent is selected from hydroxyl, ethers, esters, carboxyls, alkylsilyls and alkenyls. Experiments demonstrate that antifouling activity can be as good or better as the corresponding unsubstituted compound and that polymers functionalized so as to include or be formed from the substituted compound can be used to reduce settlement.Type: GrantFiled: February 2, 2011Date of Patent: October 27, 2015Assignees: Agency for Science, Technology and Research, National University of SingaporeInventors: Christina Li Lin Chai, Brendan Adrian Burkett, Serena Lay Ming Teo, Daniel Rittschof, Serina Siew Chen Lee, Gary Howard Dickinson, Han Hong
-
Publication number: 20130171346Abstract: Disclosed is a process for preparing fluorinated core-shell polymer particles in which the core is a non-fluorinated polymer and the shell is derived from at least 50% by weight of fluorinated monomers, by 1) synthesizing a core polymer latex by aqueous emulsion polymerization of non-fluorinated monomers forming the core polymer, 2) adding the shell-forming fluorinated monomers or mixtures of at least 50% by weight of fluorinated monomers with non-fluorinated monomers to the core polymer latex of step 1) and allowing for at least one hour of equilibration time in which essentially no polymerization of the shell monomers occurs, 3) reacting the shell-forming monomers in the mixture from step 2) to form the core-shell polymer particles, wherein the process steps 1) to 3) are carried out under mechanical stirring in the absence of surfactants, emulsifiers, emulsifying monomers and mixtures thereof.Type: ApplicationFiled: June 2, 2010Publication date: July 4, 2013Applicants: BASF SE, A*STARInventors: Parappuveetil Sarangadharan Suresh, Yoong Kim, Andreas Fechtenkotter, Han Hong, Christina Li Lin Chai, Xiaogang Yang, Yeap Hung Ng
-
Patent number: 8455935Abstract: A ferroelectric film comprising polyaminodifluoroborane (PADFB). Also a memory device utilizing the ferroelectric film, a method of fabricating a ferroelectric polymer and a ferroelectric solution.Type: GrantFiled: May 29, 2009Date of Patent: June 4, 2013Assignees: Sony Corporation, Agency for Science, Technology, and ResearchInventors: Takehisa Ishida, Sunil Madhukar Bhangale, Han Hong, Christina Li Lin Chai
-
Publication number: 20120301423Abstract: The present invention relates to derivatives of ?,?-disubstituted amide compounds which comprise a substituted aryl at the ? carbon such that the substituent provides a means for attachment or incorporation of the compound to or in a polymer. The provision of such a substituent on the aryl has surprisingly been found not only to permit attachment to or incorporation in a polymer but also retention of useful antifouling activity. In embodiments, the substituent is selected from hydroxyl, ethers, es ters, carboxyls, alkylsilyls and alkenyls. Experiments demonstrate that antifouling activity can be as good or better as the corresponding unsubstituted compound and that polymers functionalised so as to include or be formed from the substituted compound can be used to reduce settlement.Type: ApplicationFiled: February 2, 2011Publication date: November 29, 2012Applicants: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, MARITIME AND PORT AUTHORITY OF SINGAPORE, NATIONAL UNIVERSITY OF SINGAPOREInventors: Christina Li Lin Chai, Brendan Adrian Burkett, Serena Lay Ming Teo, Daniel Rittschof, Serina Siew Chen Lee, Gary Howard Dickinson, Han Hong
-
Publication number: 20090294818Abstract: A ferroelectric film comprising polyaminodifluoroborane (PADFB). Also a memory device utilizing the ferroelectric film, a method of fabricating a ferroelectric polymer and a ferroelectric solution.Type: ApplicationFiled: May 29, 2009Publication date: December 3, 2009Applicants: SONY CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Takehisa Ishida, Sunil Madhukar Bhangale, Han Hong, Christina Li Lin Chai