Abstract: The invention relates to cheese and cheese-like products comprising about 0.2 to about 6% by weight ?s-casein, ?-casein, or a combination thereof, at least about 5% by weight of one or more hydrocolloids comprising one or more starches, and wherein the cheese or cheese-like product has one or more characteristics of a dairy product, such as flavour, taste, aroma, body, appearance, texture, firmness, handling, density, structure, coagulation, binding, leavening, aeration, foaming, emulsification, elasticity, viscoelasticity, melt, creaminess and mouthfeel.

Abstract: This application relates to non-human primate (NHP) induced pluripotent stem cell (IPSC)-derived hepatocytes, for example, Cynomolgus monkey (Macaca fascicularis) induced pluripotent stem cell-derived hepatocytes, and methods of producing the same. Moreover, this application relates to methods of using NHP IPSC-derived hepatocytes for drug screening, drug safety assessment and in models of infection.

Abstract: This invention relates to an albumin-curcumin conjugate for application in cancer therapy, including albumin and curcumin.

Abstract: This application relates to a method for differentiating somatic cells into multi-competent neural crest cells based on linked steps of chemically defined medium inductions. Neural crest cells are able to differentiate into numerous cell types like Schwann cells, chondrocytes, smooth muscle cells or adipocytes.

Abstract: This application relates to a method for differentiating pluripotent stem cells (PSCs) into vascular bed cells. Moreover this application relates to a method for differentiating human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) into vascular bed cells based on linked steps of chemically defined medium inductions.

Abstract: This application relates to non-human primate (NHP) induced pluripotent stem cell (IPSC)-derived hepatocytes and methods of producing the same. Moreover, this application relates to methods of using NHP IPSC-derived hepatocytes for drug screening, drug safety assessment and in models of infection.

Abstract: This patent application relates to a method for determining the in vitro efficacy profile of a drug candidate using standardized cell cultures of uniformly distributed differentiated neural cells (NCs) from at least two primate species, wherein the differentiated NC cultures are qualified for high throughput screening based on a dissociation and reseeding step performed on the differentiated NCs. The method includes differentiating human and/or non-human primate neuronal precursor cells (NPCs) to neuronal cells (NCs) followed by dissociating the differentiated NCs from its support and reseeding the differentiated NCs in a high-throughput cell culture format resulting in robust cultures suitable for high-throughput drug screening assays, in particular to screen antisense oligonucleotides.

Abstract: This patent application relates to a method to generate standardized and robust neuronal cell culture assays from primate species, for example suitable for high-throughput screening of drug candidates. The method includes differentiating human and/or non-human primate neuronal precursor cells (NPCs) to neuronal cells (NCs) and producing uniform NC cultures based on a dissociation and reseeding step performed on the differentiated NCs resulting in robust cultures suitable for high-throughput drug screening assays, in particular to screen antisense oligonucleotides.

Abstract: This application relates to a method for differentiating somatic cells into multi-competent neural crest cells based on linked steps of chemically defined medium inductions. Neural crest cells are able to differentiate into numerous cell types like Schwann cells, chondrocytes, smooth muscle cells or adipocytes.

Abstract: This invention relates to an albumin-curcumin conjugate for application in cancer therapy, including albumin and curcumin.

Abstract: A sensitive, precise detector system for physiological analytes uses a novel system. The system comprises an immobilized polyol on a surface. Reversibly coupled to the polyol or analyte is a dendrimer structure. In the system, a signal is triggered by the dendrimer structure when in a competitive environment with an analyte at the surface. In one embodiment, the system is an implantable sensor for use by diabetic patients. The sensing system can produce a consistent, measurable response while functioning under biologically relevant conditions. The sensing system requires the interaction of two components: 1) a competitive agent/signaling component, a dendrimer-boronic acid construct (DBA) and 2) a binding environment for a glucose-competitive DBA competition, which is an immobilized monosaccharide mimic (iDIOL).

Abstract: This application relates to a method for differentiating pluripotent stem cells (PSCs) into vascular bed cells. Moreover this application relates to a method for differentiating human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) into vascular bed cells based on linked steps of chemically defined medium inductions.

Abstract: The present invention relates generally to compositions for wound healing. More specifically, the present invention provides human skin equivalents engineered to express exogenous proteinase inhibitor polypeptides (e.g., TIMP-1 polypeptides) and compositions and methods for making human skin equivalents engineered to express exogenous polypeptides. In addition, the present invention provides methods for treatment of wounds with human skin equivalents engineered to express exogenous polypeptides.

Abstract: An apparatus for forming visible lines on a surface on a temporary basis comprises at least one laser which is directed at phosphors provided in or on the surface and means for controlling the laser to cause it to sweep the area on which the lines are to be marked. Optical deflectors are provided for guiding the laser beam. A first method of forming such lines comprises sweeping the surface incorporating the phosphors and on which the lines are to be marked with at least one laser beam. In a second method, the area is again swept by the at least one laser beam and, after the phosphors have been activated, each laser beam is deactivated and the phosphors are stimulated by flood radiation. Such phopsphorescence can then be quenched at a desired time.