Patents by Inventor Christine Allen
Christine Allen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11905377Abstract: The present disclosure relates to controlling drug release in cross-linked poly(valerolactone) based matrices. In one aspect, the compounds or pharmaceutically acceptable salts thereof include a poly(valerolactone)-co-poly(allylvalerolactone)-co-polyethylene glycol (PEG) copolymer. In some embodiments, at least a portion of allylvalerolactone residues within the copolymer are crosslinked with a crosslinker. In some embodiments, the compound has a polydispersity index of less than or equal to 1.5. In one aspect, a method is described herein, comprising: (a) polymerizing valerolactone residues, allylvalerolactone, and polyethylene glycol residues in the presence of a non-metal catalyst via a ring opening polymerization to produce a poly(valerolactone)-co-poly(allylvalerolactone)-co-polyethylene glycol copolymer; (b) crosslinking the poly(valerolactone)-co-poly(allylvalerolactone)-co-polyethylene glycol copolymer with a crosslinker; and (c) loading a drug into the crosslinked copolymer.Type: GrantFiled: January 17, 2020Date of Patent: February 20, 2024Assignees: Pendant Biosciences, Inc., The Governing Council of the University of TorontoInventors: Timothy Tordella Ruckh, Carl Eric Elmquist, David Michael Stevens, Frantz Le Dévédec, Hilary Boucher, Christine Allen
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Publication number: 20230190664Abstract: Disclosed are crosslinked particles (e.g., microparticles) that are capable of storing and releasing drugs. The particles can be macroparticles, microparticles, or nanoparticles and can be composed of polyester backbones. The particles can be loaded with a drug. The particles can degrade in vivo to release the drug. The particles can be prepared by crosslinking functionalized polyester backbones and loaded with a given drug. The particles of the present disclosure can be injected with a syringe. In some embodiments, the particles of the present disclosure are administered in connection with a surgery and release the drug after the site of the surgery for a period of 1-6 months.Type: ApplicationFiled: July 22, 2022Publication date: June 22, 2023Inventors: Frantz LE DEVEDEC, Christine ALLEN, David M. STEVENS, Dean James RAGER-AGUIAR, Timothy Tordella RUCKH, Carl Eric ELMQUIST
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Patent number: 11607454Abstract: Devices, materials, compounds, systems, and processes for Cherenkov-Activated Nuclear-Targeted Photodynamic Therapy that involves generating Cherenkov light within the tissue of a target volume and using this light to activate photosensitizing material that is located in the nucleus of cells of the target volume.Type: GrantFiled: May 19, 2017Date of Patent: March 21, 2023Assignee: UNIVERSITY HEALTH NETWORKInventors: Brian Wilson, Christine Allen
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Patent number: 11426356Abstract: Disclosed are crosslinked particles (e.g., microparticles) that are capable of storing and releasing drugs. The particles can be macroparticles, microparticles, or nanoparticles and can be composed of polyester backbones. The particles can be loaded with a drug. The particles can degrade in vivo to release the drug. The particles can be prepared by crosslinking functionalized polyester backbones and loaded with a given drug. The particles of the present disclosure can be injected with a syringe. In some embodiments, the particles of the present disclosure are administered in connection with a surgery and release the drug after the site of the surgery for a period of 1-6 months.Type: GrantFiled: February 27, 2019Date of Patent: August 30, 2022Assignees: Pendant Biosciences, Inc., The Governing Council of the University of TorontoInventors: Frantz Le Devedec, Christine Allen, David M. Stevens, Dean James Rager-Aguiar, Timothy Tordella Ruckh, Carl Eric Elmquist
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Patent number: 11077214Abstract: The present application relates to compositions comprising an iodinated contrast agent and indocyanine green co-encapsulated inside a liposomal carrier, various uses thereof as well as methods for their preparation.Type: GrantFiled: May 26, 2014Date of Patent: August 3, 2021Assignee: University Health NetworkInventors: Jinzi Zheng, David A. Jaffray, Christine Allen
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Publication number: 20200407514Abstract: The present disclosure relates to controlling drug release in cross-linked poly(valerolactone) based matrices. In one aspect, the compounds or pharmaceutically acceptable salts thereof include a poly(valerolactone)-co-poly(allylvalerolactone)-co-polyethylene glycol (PEG) copolymer. In some embodiments, at least a portion of allylvalerolactone residues within the copolymer are crosslinked with a crosslinker. In some embodiments, the compound has a polydispersity index of less than or equal to 1.5. In one aspect, a method is described herein, comprising: (a) polymerizing valerolactone residues, allylvalerolactone, and polyethylene glycol residues in the presence of a non-metal catalyst via a ring opening polymerization to produce a poly(valerolactone)-co-poly(allylvalerolactone)-co-polyethylene glycol copolymer; (b) crosslinking the poly(valerolactone)-co-poly(allylvalerolactone)-co-polyethylene glycol copolymer with a crosslinker; and (c) loading a drug into the crosslinked copolymer.Type: ApplicationFiled: January 17, 2020Publication date: December 31, 2020Inventors: Timothy Tordella Ruckh, Carl Eric Elmquist, David Michael Stevens, Frantz Le Dévédec, Hilary Boucher, Christine Allen
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Publication number: 20200316200Abstract: Devices, materials, compounds, systems, and processes for Cherenkov-Activated Nuclear-Targeted Photodynamic Therapy that involves generating Cherenkov light within the tissue of a target volume and using this light to activate photosensitizing material that is located in the nucleus of cells of the target volume.Type: ApplicationFiled: May 19, 2017Publication date: October 8, 2020Applicants: UNIVERSITY HEALTH NETWORK, THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTOInventors: Brian WILSON, Christine ALLEN
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Publication number: 20190262274Abstract: Disclosed are crosslinked particles (e.g., microparticles) that are capable of storing and releasing drugs. The particles can be macroparticles, microparticles, or nanoparticles and can be composed of polyester backbones. The particles can be loaded with a drug. The particles can degrade in vivo to release the drug. The particles can be prepared by crosslinking functionalized polyester backbones and loaded with a given drug. The particles of the present disclosure can be injected with a syringe. In some embodiments, the particles of the present disclosure are administered in connection with a surgery and release the drug after the site of the surgery for a period of 1-6 months.Type: ApplicationFiled: February 27, 2019Publication date: August 29, 2019Inventors: Frantz Le Devedec, Christine Allen, David M. Stevens, Dean James Rager-Aguiar, Timothy Tordella Ruckh, Carl Eric Elmquist
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Patent number: 9393326Abstract: There is provided signal modifying compositions for medical imaging comprising a carrier and signal modifying agents specific for two or more imaging modalities. The compositions are characterized by retention efficiency, with respect of the signal modifying agents that enables prolonged contrast imaging without significant depletion of the signal modifying agent from the carrier. The carriers of the present invention are lipid based or polymer based the physico-chemical properties of which can be modified to entrap or chelate different signal modifying agents and mixtures thereof and to target specific organs or tumors or tissues within a mammal.Type: GrantFiled: March 12, 2014Date of Patent: July 19, 2016Assignee: University Health NetworkInventors: David Jaffray, Christine Allen, Jinzi Zheng, Raymond Matthew Reilly, Gregory Jason Perkins
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Publication number: 20160095944Abstract: The present application relates to compositions comprising an iodinated contrast agent and indocyanine green co-encapsulated inside a liposomal carrier, various uses thereof as well as methods for their preparation.Type: ApplicationFiled: May 26, 2014Publication date: April 7, 2016Applicant: University Health NetworkInventors: Jinzi Zheng, David A. Jaffray, Christine Allen
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Patent number: 9269529Abstract: A method for performing DA (Dynamic Alignment) beam calibration in a plasma processing system is provided. The method including acquiring a positional difference, the positional difference is acquired using an optical imaging approach. The optical imaging approach comprising of positioning the wafer on the end effector, taking a still image of the wafer on the end effector, processing the still image to ascertain the center of the wafer and an end effector-defined center defined by the end effector, and determining the positional difference between the center of the wafer and the end effector-defined center defined by the end effector. The method also includes centering a wafer with respect to an end effector by compensating for a positional difference between the wafer and the end effector with robot movement compensation. The method including moving the wafer and the end effector through DA beams associated with a plasma processing module.Type: GrantFiled: December 19, 2008Date of Patent: February 23, 2016Assignee: LAM RESEARCH CORPORATIONInventors: Matt Rodnick, Christine Allen-Blanchette
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Patent number: 8954287Abstract: A method for calibrating alignment of an end effector with respect to a chuck in a plasma processing system is disclosed. The method includes providing a first light beam from the end effector to said chuck, moving the end effector along a predefined calibration path such that the first light beam traverses a surface of the chuck, receiving a set of reflected light signals being generated at least when the surface reflects the first light beam during the moving, and analyzing the set of reflected light signals to identify three or more discontinuities, generated when the first light beam encounters an edge of the chuck. The method also includes determining three or more coordinate data points representing three or more points on the edge of the chuck, and determining a center of the chuck based on the three or more coordinate data points.Type: GrantFiled: December 19, 2008Date of Patent: February 10, 2015Assignee: Lam Research CorporationInventors: Matt Rodnick, Christine Allen-Blanchette
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Patent number: 8860955Abstract: A method for determining positions and offsets in a plasma processing system, the plasma processing system including at least a chuck and an upper electrode is provided. The method including moving a traversing assembly along a first plurality of paths to generate a first plurality of data sets, the traversing assembly including at least a light source, the light source providing a light beam, moving the traversing assembly along each path of the first plurality of paths causing the light beam to traverse the chuck and resulting in one or more data sets of the first plurality of data sets. The method also including receiving the first plurality of data sets and analyzing the first plurality of data sets to identify a first set of at least three discontinuities, wherein the first set of at least three discontinuities are related to three or more reflected light signals generated when the light beam encounters an edge of the chuck.Type: GrantFiled: December 19, 2008Date of Patent: October 14, 2014Assignee: Lam Research CorporationInventors: Matt Rodnick, Christine Allen-Blanchette
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Publication number: 20140193330Abstract: There is provided signal modifying compositions for medical imaging comprising a carrier and signal modifying agents specific for two or more imaging modalities. The compositions are characterized by retention efficiency, with respect of the signal modifying agents that enables prolonged contrast imaging without significant depletion of the signal modifying agent from the carrier. The carriers of the present invention are lipid based or polymer based the physico-chemical properties of which can be modified to entrap or chelate different signal modifying agents and mixtures thereof and to target specific organs or tumors or tissues within a mammal.Type: ApplicationFiled: March 12, 2014Publication date: July 10, 2014Applicant: University Health NetworkInventors: David JAFFRAY, Christine ALLEN, Jinzi ZHENG, Raymond Matthew REILLY, Gregory Jason PERKINS
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Patent number: 8751047Abstract: A method for calibrating alignment of an end effector with respect to a chuck in a plasma processing system is provided. The method including positioning the end effector over the chuck and taking a still image of the chuck and the end effector. The method including processing the still image to ascertain the center of the chuck and the end effector-defined center defined by the end effector. The method including determining a positional difference between the end effector-defined center and the center of the chuck. The method also including providing the positional difference to a robot controller to control a robot mechanism to adjust the positional difference when the end effector transports a wafer.Type: GrantFiled: December 19, 2008Date of Patent: June 10, 2014Assignee: Lam Research CorporationInventors: Matt Rodnick, Christine Allen-Blanchette
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Patent number: 8703097Abstract: Provided are signal modifying compositions for medical imaging comprising a carrier and two or more signal modifying agents specific for two or more imaging modalities. The compositions are characterized by retention efficiency, with respect to the signal modifying agents, which enables prolonged contrast imaging without significant depletion of the signal modifying agents from the carrier. The carriers of the present invention are lipid based or polymer based, the physico-chemical properties of which can be modified to entrap or chelate different signal modifying agents and mixtures thereof and to target specific organs or tumors or tissues within a mammal.Type: GrantFiled: February 10, 2006Date of Patent: April 22, 2014Assignee: University Health NetworkInventors: David Jaffray, Christine Allen, Jinzi Zheng, Raymond Matthew Reilly, Gregory Jason Perkins
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Publication number: 20130261371Abstract: Imageable disruptable capsules containing a sensitizing agent or a protecting agent are used to enhance radiation therapy. Said capsules may be imaged by a non-invasive imaging modality, allowing for the determination of the precise timing to disrupt the capsule and release the sensitizing agent or protecting agent using an external energy source. This controlled and timed release of the sensitizing agent or protecting agent provides for enhanced radiation therapy by optimizing the delivery of the sensitizing agent or protecting agent to the target tissues. Systems comprising non-invasive imaging modalities, external energy sources and radiation energy sources are also taught for use with these imageable disruptable capsules.Type: ApplicationFiled: May 3, 2011Publication date: October 3, 2013Applicant: UNIVERSITY HEALTH NETWORKInventors: David A. Jaffray, Christine Allen, Devika Chithrani, Jinzi Zheng, Justin Grant
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Patent number: 7901707Abstract: Formulations or delivery systems are provided for controlled release of therapeutically active agents. The delivery systems are composed of polymer and lipid materials and may be prepared as a gel, paste, solution, film, implant or barrier depending on the intended application. The polymer component of the matrix is the naturally occurring biomaterial, chitosan, or a mixture of chitin and chitosan. The lipid component may include phosphatidylcholine, phosphatidylserine, phosphatidylinositol, phosphatidyl or a mixture thereof. The delivery system may be used for delivery of hydrophilic agents, hydrophobic agents or combinations thereof. The therapeutically active agents may be formulated within the matrix as free agents or incorporated into particles. In a preferred embodiment the agents are incorporated into polymeric particles that are dispersed throughout the matrix.Type: GrantFiled: March 15, 2005Date of Patent: March 8, 2011Inventors: Christine Allen, Justin Grant, Micheline Piquette-Miller
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Publication number: 20100280790Abstract: A method for calibrating alignment of an end effector with respect to a chuck in a plasma processing system is provided. The method including providing a first light beam from the end effector to said chuck. The method including moving the end effector along a predefined calibration path such that the first light beam traverses a surface of the chuck. The method also includes receiving a set of reflected light signals, the set of reflected light signals being generated at least when the surface reflects the first light beam during the moving. The method including analyzing the set of reflected light signals to identify three or more discontinuities. The three or more discontinuities are related to three or more reflected light signals generated when the first light beam encounters an edge of the chuck.Type: ApplicationFiled: December 19, 2008Publication date: November 4, 2010Inventors: Matt Rodnick, Christine Allen-Blanchette
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Patent number: D993634Type: GrantFiled: April 2, 2021Date of Patent: August 1, 2023Inventor: Christine Allen