Patents by Inventor Christine Cezar
Christine Cezar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11690387Abstract: Provided herein are methods and compositions for food and feed applications, e.g., for targeting one or more microorganisms resident in a host insect, the modulation resulting in an increase in the fitness of the host. The invention features a composition that includes a modulating agent (e.g., phage, peptide, small molecule, antibiotic, or combinations thereof) that can alter the host's microbiota in a manner that is beneficial to the host. By promoting favorable microbial levels, microbial activity, microbial metabolism, and/or microbial diversity, the modulating agent described herein may be used to increase the fitness of a variety of insects utilized in human food or animal feed industries.Type: GrantFiled: January 24, 2018Date of Patent: July 4, 2023Assignee: Flagship Pioneering Innovations V, Inc.Inventors: Ignacio Martinez, Zachary Garo Armen, Christine Cezar, Barry Andrew Martin, Maier Steve Avendano Amado
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Patent number: 11350648Abstract: Provided herein are agents, compositions, and methods for agricultural use, e.g., for altering the level, activity, or metabolism of one or more microorganisms resident in a host nematode or arthropod (e.g., honeybee or silkworm), the alteration resulting in an increase in the fitness of the host. The invention features a composition that includes an agent (e.g., phage, peptide, small molecule, antibiotic, or combinations thereof) that can alter the host's microbiota in a manner that is beneficial to the host. By promoting favorable microbial levels, microbial activity, microbial metabolism, and/or microbial diversity, the agents described herein may be used to increase the fitness of a variety of beneficial nematodes or arthropods, such as bees and silkworms, utilized in agriculture and commerce.Type: GrantFiled: January 24, 2018Date of Patent: June 7, 2022Assignee: Flagship Pioneering Innovations V, Inc.Inventors: Ignacio Martinez, Zachary Garo Armen, Jonathan Friedlander, Christine Cezar, Barry Andrew Martin, Maier Steve Avendano Amado
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Patent number: 11197944Abstract: The present invention provides methods and compositions for promoting regeneration of a tissue, methods for preventing or reducing inflammation of a tissue, methods for preventing or reducing fibrosis of a tissue, methods for increasing a mass of a tissue, methods for increasing a level of oxygen available to a tissue, methods for increasing a rate of metabolic waste removal from a tissue, methods for increasing blood perfusion to a tissue, and methods of treating severe muscle tissue damage in a subject in need thereof by contacting the tissue with a composition that is suitable for applying cyclic mechanical compression to the tissue.Type: GrantFiled: November 18, 2016Date of Patent: December 14, 2021Assignees: President and Fellows of Harvard College, CHARITÉ UNIVERSITÄTSMEDIZIN BERLINInventors: Christine A. Cezar, Conor J. Walsh, David J. Mooney, Ellen T. Roche, Herman H. Vandenburgh, Georg N. Duda
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Publication number: 20210275635Abstract: Provided herein are methods and compositions useful for human health, e.g., for targeting one or more microorganisms resident in a host insect (e.g., arthropod, e.g., insect, e.g., pathogen vector), the modulation resulting in a decrease in the fitness of the host. The invention features a composition that includes a modulating agent (e.g., phage, peptide, small molecule, antibiotic, or combinations thereof) that can alter the host's microbiota in a manner that is detrimental to the host. By disrupting microbial levels, microbial activity, microbial metabolism, or microbial diversity, the modulating agent described herein may be used to decrease the fitness of a variety of insects that carry vector-home pathogens that cause disease in humans.Type: ApplicationFiled: December 14, 2020Publication date: September 9, 2021Inventors: Ignacio MARTINEZ, Zachary Garo ARMEN, Christine CEZAR, Barry Andrew MARTIN, Maier Steve AVENDANO AMADO
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Publication number: 20210195917Abstract: Provided herein are agents, compositions, and methods for agricultural use, e.g., for altering the level, activity, or metabolism of one or more microorganisms resident in a host nematode or arthropod (e.g., honeybee or silkworm), the alteration resulting in an increase in the fitness of the host. The invention features a composition that includes an agent (e.g., phage, peptide, small molecule, antibiotic, or combinations thereof) that can alter the host's microbiota in a manner that is beneficial to the host. By promoting favorable microbial levels, microbial activity, microbial metabolism, and/or microbial diversity, the agents described herein may be used to increase the fitness of a variety of beneficial nematodes or arthropods, such as bees and silkworms, utilized in agriculture and commerce.Type: ApplicationFiled: July 27, 2020Publication date: July 1, 2021Inventors: Ignacio MARTINEZ, Zachary Garo ARMEN, Jonathan FRIEDLANDER, Christine CEZAR, Barry Andrew MARTIN, Maier Steve AVENDANO AMADO
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Publication number: 20200261536Abstract: Provided herein are methods and compositions useful for human health, e.g., for targeting one or more microorganisms resident in a host insect (e.g., arthropod, e.g., insect, e.g., pathogen vector), the modulation resulting in a decrease in the fitness of the host. The invention features a composition that includes a modulating agent (e.g., phage, peptide, small molecule, antibiotic, or combinations thereof) that can alter the host's microbiota in a manner that is detrimental to the host. By disrupting microbial levels, microbial activity, microbial metabolism, or microbial diversity, the modulating agent described herein may be used to decrease the fitness of a variety of insects that carry vector-bore pathogens that cause disease in humans.Type: ApplicationFiled: March 23, 2020Publication date: August 20, 2020Inventors: Ignacio MARTINEZ, Zachary Garo ARMEN, Christine CEZAR, Barry Andrew MARTIN, Maier Steve AVENDANO AMADO
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Publication number: 20200222582Abstract: The present invention provides methods and compositions for promoting regeneration of a tissue, methods for preventing or reducing inflammation of a tissue, methods for preventing or reducing fibrosis of a tissue, methods for increasing a mass of a tissue, methods for increasing a level of oxygen available to a tissue, methods for increasing a rate of metabolic waste removal from a tissue, methods for increasing blood perfusion to a tissue, and methods of treating severe muscle tissue damage in a subject in need thereof by contacting the tissue with a composition that is suitable for applying cyclic mechanical compression to the tissue.Type: ApplicationFiled: November 18, 2016Publication date: July 16, 2020Inventors: Christine A. Cezar, Conor J. Walsh, David J. Mooney, Ellen T. Roche, Herman H. Vandenburgh, Georg N. Duda
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Publication number: 20200129565Abstract: Provided herein are agents, compositions, and methods for agricultural use, e.g., for altering the level, activity, or metabolism of one or more microorganisms resident in a host nematode or arthropod (e.g., honeybee or silkworm), the alteration resulting in an increase in the fitness of the host. The invention features a composition that includes an agent (e.g., phage, peptide, small molecule, antibiotic, or combinations thereof) that can alter the host's microbiota in a manner that is beneficial to the host. By promoting favorable microbial levels, microbial activity, microbial metabolism, and/or microbial diversity, the agents described herein may be used to increase the fitness of a variety of beneficial nematodes or arthropods, such as bees and silkworms, utilized in agriculture and commerce.Type: ApplicationFiled: January 24, 2018Publication date: April 30, 2020Applicant: Flagship Pioneering Innovations V, Inc.Inventors: Ignacio MARTINEZ, Zachary Garo ARMEN, Jonathan FRIEDLANDER, Christine CEZAR, Barry Andrew MARTIN, Maier Steve AVENDANO AMADO
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Publication number: 20200128856Abstract: Provided herein are methods and compositions for food and feed applications, e.g., for targeting one or more microorganisms resident in a host insect, the modulation resulting in an increase in the fitness of the host. The invention features a composition that includes a modulating agent (e.g., phage, peptide, small molecule, antibiotic, or combinations thereof) that can alter the host's microbiota in a manner that is beneficial to the host. By promoting favorable microbial levels, microbial activity, microbial metabolism, and/or microbial diversity, the modulating agent described herein may be used to increase the fitness of a variety of insects utilized in human food or animal feed industries.Type: ApplicationFiled: January 24, 2018Publication date: April 30, 2020Applicant: Flagship Pioneering Innovations V, Inc.Inventors: Ignacio MARTINEZ, Zachary Garo ARMEN, Christine CEZAR, Barry Andrew MARTIN, Maier Steve AVENDANO AMADO
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Publication number: 20190365853Abstract: Provided herein are methods and compositions useful for human health, e.g., for targeting one or more microorganisms resident in a host insect (e.g., arthropod, e.g., insect, e.g., pathogen vector), the modulation resulting in a decrease in the fitness of the host. The invention features a composition that includes a modulating agent (e.g., phage, peptide, small molecule, antibiotic, or combinations thereof) that can alter the host's microbiota in a manner that is detrimental to the host. By disrupting microbial levels, microbial activity, microbial metabolism, or microbial diversity, the modulating agent described herein may be used to decrease the fitness of a variety of insects that carry vector-borne pathogens that cause disease in humans.Type: ApplicationFiled: January 24, 2018Publication date: December 5, 2019Inventors: Ignacio MARTINEZ, Zachary Garo ARMEN, Christine CEZAR, Barry Andrew MARTIN, Maier Steve AVENDANO AMADO
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Publication number: 20190191741Abstract: Provided herein are agents, compositions, and methods for agricultural use, e.g., for altering the level, activity, or metabolism of one or more microorganisms resident in a host nematode or arthropod (e.g., honeybee or silkworm), the alteration resulting in an increase in the fitness of the host. The invention features a composition that includes an agent (e.g., phage, peptide, small molecule, antibiotic, or combinations thereof) that can alter the host's microbiota in a manner that is beneficial to the host. By promoting favorable microbial levels, microbial activity, microbial metabolism, and/or microbial diversity, the agents described herein may be used to increase the fitness of a variety of beneficial nematodes or arthropods, such as bees and silkworms, utilized in agriculture and commerce.Type: ApplicationFiled: March 1, 2019Publication date: June 27, 2019Inventors: Ignacio Martinez, Zachary Garo Armen, Jonathan Friedlander, Christine Cezar, Barry Andrew Martin, Maier Steve Avendano Amado