Abstract: The present invention relates to an immunogenic polypeptide isolated from Mycobacterium avium subspecies paratuberculosis and variants of the polypeptide. The polypeptide and variants may be used in vaccines against Johne's disease and in methods for detection of the disease. Antibodies against the polypeptide or variants may be used in diagnostic tests for Johne's disease. Also included are polynucleotides encoding the polypeptide and variants, and methods for preparing these.

Abstract: The present invention relates to a fluidic device that can be used for the analysis of surface-dwelling multicellular layers, some of which comprise biofilm and can be referred to as biofilms, and their formation under controlled dynamic conditions. More particularly, the surface in the fluidic chamber on which the multicellular layer is grown is detachable and/or removable from the fluidic chamber, thereby providing a highly versatile device.

Abstract: The invention relates to a process for the production of a transparent support covered with a deposit of inorganic nanoparticles, said deposit having micro gaps, comprising the following steps: application of a solution of polyelectrolyte having ionized functional groups to a transparent support, followed by at least one washing and drying step to form a charged polyelectrolyte deposit on said support; application of a solution of polymer microparticles having ionized groups with charges opposed to those of the polyelectrolyte deposit to said polyelectrolyte deposit, followed by at least one washing step for the formation of a deposit of charged polymer microparticles on the polyelectrolyte deposit; covering the deposit of charged polymer microparticles with a solution of polyelectrolyte having ionized functional groups with charges opposed to those of the charged polymer microparticles of step (b), followed by at least one washing and drying step to form a charged polyelectrolyte deposit; application of a s

Abstract: The invention relates to a process for the production of a transparent support covered with a deposit of inorganic nanoparticles, said deposit having micro gaps, comprising the following steps: application of a solution of polyelectrolyte having ionised functional groups to a transparent support, followed by at least one washing and drying step to form a charged polyelectrolyte deposit on said support; application of a solution of polymer microparticles having ionised groups with charges opposed to those of the polyelectrolyte deposit to said polyelectrolyte deposit, followed by at least one washing step for the formation of a deposit of charged polymer microparticles on the polyelectrolyte deposit; covering the deposit of charged polymer microparticles with a solution of polyelectrolyte having ionised functional groups with charges opposed to those of the charged polymer microparticles of step (b), followed by at least one washing and drying step to form a charged polyelectrolyte deposit; application of a s

Abstract: The present invention relates to an immunogenic polypeptide isolated from Mycobacterium avium subspecies paratuberculosis and variants of the polypeptide. The polypeptide and variants may be used in vaccines against Johne's disease and in methods for detection of the disease. Antibodies against the polypeptide or variants may be used in diagnostic tests for Johne's disease. Also included are polynucleotides encoding the polypeptide and variants, and methods for preparing these.

Abstract: The invention provides a vaccine comprising secreted protein derived from Mycobacterium avium subsp paratuberculosis (M. ptb) substantially free of whole organisms of that species either dead or alive. The secreted protein may be obtained from a culture of M. ptb with the microorganisms being removed by centrifugation and subsequent filtration. The vaccine may be used for vaccination against Johne's disease.

Abstract: The present invention relates to an immunogenic polypeptide isolated from Mycobacterium avium subspecies paratuberculosis and variants of the polypeptide. The polypeptide and variants may be used in vaccines against Johne's disease and in methods for detection of the disease. Antibodies against the polypeptide or variants may be used in diagnostic tests for Johne's disease. Also included are polynucleotides encoding the polypeptide and variants, and methods for preparing these.

Abstract: The invention provides a vaccine comprising secreted protein derived from Mycobacterium avium subsp paratuberculosis (M. ptb) substantially free of whole organisms of that species either dead or alive. The secreted protein may be obtained from a culture of M. ptb with the microorganisms being removed by centrifugation and subsequent filtration.

Abstract: The invention provides a vaccine comprising secreted protein derived from Mycobacterium avium subsp paratuberculosis (M. ptb) substantially free of whole organisms of that species either dead or alive. The secreted protein may be obtained from a culture of M. ptb with the microorganisms being removed by centrifugation and subsequent filtration. The vaccine may be used for vaccination against Johne's disease.

Abstract: The present invention relates to an immunogenic polypeptide isolated from Mycobacterium avium subspecies paratuberculosis and variants of the polypeptide. The polypeptide and variants may be used in vaccines against Johne's disease and in methods for detection of the disease. Antibodies against the polypeptide or variants may be used in diagnostic tests for Johne's disease. Also included are polynucleotides encoding the polypeptide and variants, and methods for preparing these.

Abstract: The invention provides a vaccine comprising secreted protein derived from Mycobacterium avium subsp paratuberculosis (M. ptb) substantially free of whole organisms of that species either dead or alive. The secreted protein may be obtained from a culture of M. ptb with the microorganisms being removed by centrifugation and subsequent filtration. The vaccine may be used for vaccination against Johne's disease.