Patents by Inventor Christine M. Ambrose

Christine M. Ambrose has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL RECEPTOR NUCLEIC ACIDS AND POLYPEPTIDES
    Publication number: 20140187485
    Abstract: Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including the same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pharmaceutical compositions of this invention are also provided.
    Type: Application
    Filed: August 2, 2013
    Publication date: July 3, 2014
    Applicant: BIOGEN IDEC MA INC.
    Inventors: Christine M. Ambrose, Jeffrey S. Thompson
  • Method for inhibiting BAFF-R activity
    Patent number: 8524672
    Abstract: Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including the same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pharmaceutical compositions of this invention are also provided.
    Type: Grant
    Filed: August 19, 2011
    Date of Patent: September 3, 2013
    Assignee: Biogen Idec MA Inc.
    Inventors: Christine M. Ambrose, Jeffrey S. Thompson
  • METHOD OF IDENTIFYING COMPOUNDS THAT BIND BAFF-R
    Publication number: 20120070437
    Abstract: Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including the same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pharmaceutical compositions of this invention are also provided.
    Type: Application
    Filed: August 19, 2011
    Publication date: March 22, 2012
    Inventors: Christine M. Ambrose, Jeffrey S. Thompson
  • Method of identifying compounds that bind BAFF-R
    Patent number: 8026072
    Abstract: Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including the same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pharmaceutical compositions of this invention are also provided.
    Type: Grant
    Filed: March 2, 2010
    Date of Patent: September 27, 2011
    Assignee: Biogen Idec MA Inc.
    Inventors: Christine M. Ambrose, Jeffrey S. Thompson
  • Novel Receptor Nucleic Acids and Polypeptides
    Publication number: 20100311189
    Abstract: Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including the same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pharmaceutical compositions of this invention are also provided.
    Type: Application
    Filed: March 2, 2010
    Publication date: December 9, 2010
    Inventors: Christine M. Ambrose, Jeffrey S. Thompson
  • POLYPEPTIDES THAT BIND BR3 AND USES THEREOF
    Publication number: 20100280227
    Abstract: The present invention relates to novel BR3 binding antibodies and polypeptides, including antagonist and agonist polypeptides. The present invention also relates to the use of the BR3 binding antibodies and polypeptides in, e.g., methods of treatment, screening methods, diagnostic methods, assays and protein purification methods.
    Type: Application
    Filed: July 13, 2010
    Publication date: November 4, 2010
    Applicant: GENENTECH, INC.
    Inventors: CHRISTINE M. AMBROSE, MERCEDESZ BALAZS, LAURA DEFORGE, MARK S. DENNIS, GERMAINE FUH, STEPHEN D. HURST, CHINGWEI V. LEE, HENRY B. LOWMAN, FLAVIUS MARTIN, GERALD R. NAKAMURA, DHAYA SESHASAYEE, MELISSA A. STAROVASNIK, JEFFREY S. THOMPSON
  • ALTERED BR-3 BINDING POLYPEPTIDES
    Publication number: 20100166741
    Abstract: The present invention relates to novel BR3 binding antibodies having altered Fc effector function and/or having a mature core carbohydrate structure in the Fc region which lacks fiicose. The present invention also relates to the use of those BR3 binding antibodies and polypeptides in, e.g., methods of treatment, screening methods, diagnostic methods, assays and protein purification methods.
    Type: Application
    Filed: July 12, 2007
    Publication date: July 1, 2010
    Applicants: Genentech , Inc., Biogen Idec Ma Inc.
    Inventors: Robert F. Kelley, Amy Yijuan Shen, Dorothea Reilly, Mark S. Dennis, Germaine Fuh, Chingwei V. Lee, Christine M. Ambrose, Jeffrey S. Thompson
  • Methods of monitoring treatment of BAFF-R related disease
    Patent number: 7709220
    Abstract: Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including the same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pharmaceutical compositions of this invention are also provided.
    Type: Grant
    Filed: June 23, 2006
    Date of Patent: May 4, 2010
    Assignee: Biogen Idec MA Inc.
    Inventors: Christine M. Ambrose, Jeffrey S. Thompson
  • BAFF receptor antibodies and methods
    Patent number: 7638327
    Abstract: Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including the same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pharmaceutical compositions of this invention are also provided.
    Type: Grant
    Filed: June 23, 2006
    Date of Patent: December 29, 2009
    Assignee: Biogen IDEC MA Inc.
    Inventors: Christine M. Ambrose, Jeffrey S. Thompson
  • BAFF receptor polypeptides
    Patent number: 7635677
    Abstract: Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including the same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pharmaceutical compositions of this invention are also provided.
    Type: Grant
    Filed: June 23, 2006
    Date of Patent: December 22, 2009
    Assignee: Biogen IDEC MA Inc.
    Inventors: Christine M. Ambrose, Jeffrey S. Thompson
  • Polypeptides That Bind Br3 and Uses Thereof
    Publication number: 20080181888
    Abstract: The present invention relates to novel BR3 binding antibodies and polypeptides, including antagonist and agonist polypeptides. The present invention also relates to the use of the BR3 binding antibodies and polypeptides in, e.g., methods of treatment, screening methods, diagnostic methods, assays and protein purification methods.
    Type: Application
    Filed: December 23, 2005
    Publication date: July 31, 2008
    Inventors: Christine M. Ambrose, Mercedesz Balazs, Laura DeForge, Mark S. Dennis, Germaine Fuh, Stephen D. Hurst, Chingwei V. Lee, Henry B. Lowman, Flavius Martin, Gerald R. Nakamura, Dhaya Seshasayee, Melissa Starovasnik, Jeffrey S. Thompson
  • Nucleic acids encoding BAFF receptor, chimeric proteins and methods and compositions related thereto
    Patent number: 7112421
    Abstract: Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pharmaceutical compositions of this invention are also provided.
    Type: Grant
    Filed: September 6, 2001
    Date of Patent: September 26, 2006
    Assignee: Biogen Idec MA Inc.
    Inventors: Christine M. Ambrose, Jeffrey S. Thompson
  • Novel receptor nucleic acids and polypeptides
    Publication number: 20040072188
    Abstract: Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pharmaceutical compositions of this invention are also provided.
    Type: Application
    Filed: July 28, 2003
    Publication date: April 15, 2004
    Inventors: Christine M. Ambrose, Jeffrey S. Thompson
  • Huntingtin DNA, protein and uses thereof
    Patent number: 5693757
    Abstract: A novel gene, huntingtin, is described, encoding huntingtin protein, recombinant vectors and hosts capable of expressing huntingtin. Methods for the diagnosis and treatment of Huntington's disease are also provided.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: December 2, 1997
    Assignee: The General Hospital Corporation
    Inventors: Marcy E. MacDonald, Christine M. Ambrose, Mabel P. Duyao, James F. Gusella
  • Huntingtin DNA, protein and uses thereof
    Patent number: 5686288
    Abstract: A novel gene, huntingtin, is described, encoding huntingtin protein, recombinant vectors and hosts capable of expressing huntingtin. Methods for the diagnosis and treatment of Huntington's disease are also provided.
    Type: Grant
    Filed: May 20, 1994
    Date of Patent: November 11, 1997
    Assignee: The General Hospital Corporation
    Inventors: Marcy E. MacDonald, Christine M. Ambrose, Mabel P. Duyao, James F. Gusella