Patents by Inventor Christine Stelmach

Christine Stelmach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystal forms of (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one
    Publication number: 20060009641
    Abstract: The instant invention describes a method for crystallizing (?)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one from a solvent and anti-solvent solvent system and producing the crystalline product. The desired final crystal form, Form I, can be produced when using methanol or ethanol. Form II is isolated from 2-propanol and can be converted to the desired crystal form at low drying temperatures, such as between about a temperature of 40° C. and 50° C.
    Type: Application
    Filed: September 1, 2005
    Publication date: January 12, 2006
    Inventors: Louis Crocker, Joseph Kukura, Andrew Thompson, Christine Stelmach, Steven Young
  • Crystal forms of (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one
    Patent number: 6939964
    Abstract: The instant invention describes a method for crystallizing (?)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one from a solvent and anti-solvent solvent system and producing the crystalline product. The desired final crystal form, Form I, can be produced when using methanol or ethanol. Form II is isolated from 2-propanol and can be converted to the desired crystal form at low drying temperatures, such as between about a temperature of 40° C. and 50° C.
    Type: Grant
    Filed: June 24, 2004
    Date of Patent: September 6, 2005
    Assignee: Merck & Co., Inc.
    Inventors: Louis S. Crocker, Joseph L. Kukura, II, Andrew S. Thompson, Christine Stelmach, Steven D. Young
  • Crystal forms of (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one
    Publication number: 20040259872
    Abstract: The instant invention describes a method for crystallizing (−)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one from a solvent and anti-solvent solvent system and producing the crystalline product. The desired final crystal form, Form I, can be produced when using methanol or ethanol. Form II is isolated from 2-propanol and can be converted to the desired crystal form at low drying temperatures, such as between about a temperature of 40° C. and 50° C.
    Type: Application
    Filed: June 24, 2004
    Publication date: December 23, 2004
    Inventors: Louis S. Crocker, Joseph L. Kukura, Andrew S. Thompson, Christine Stelmach, Steven D. Young
  • Ophthalmic compositions for treating ocular hypertension
    Publication number: 20040058976
    Abstract: This invention relates a formulation comprising potent potassium channel blockers or pharmaceutically acceptable salts thereof in combination with peanut oil for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
    Type: Application
    Filed: July 16, 2003
    Publication date: March 25, 2004
    Inventor: Christine Stelmach
  • Dry granulation formulation for an HIV protease inhibitor
    Patent number: 6645961
    Abstract: This invention relates to a dry granulation capsule formulation of the HIV protease inhibitor, indinavir sulfate, which is useful in the treatment of AIDS, ARC or HIV infection. Processes for making the oral formulation are also disclosed.
    Type: Grant
    Filed: March 4, 1998
    Date of Patent: November 11, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Chung Y. Lui, Drazen Ostovic, Ashok V. Katdare, Christine Stelmach
  • Crystal forms of (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one
    Publication number: 20030208070
    Abstract: The instant invention describes a method for crystallizing (−)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one from a solvent and anti-solvent solvent system and producing the crystalline product. The desired final crystal form, Form I, can be produced when using methanol or ethanol. Form II is isolated from 2-propanol and can be converted to the desired crystal form at low drying temperatures, such as between about a temperature of 40° C. and 50° C.
    Type: Application
    Filed: May 29, 2003
    Publication date: November 6, 2003
    Inventors: Louis S. Crocker, Joseph L. Kukura, Andrew S. Thompson, Christine Stelmach, Steven D. Young
  • Crystal Forms of (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one
    Patent number: 6639071
    Abstract: The instant invention describes a method for crystallizing (−)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one from a solvent and anti-solvent system and producing the crystalline product. The desired final crystal form, Form I, can be produced when using methanol or ethanol. Form II is isolated from 2-propanol and can be converted to the desired crystal form at low drying temperatures, such as between about a temperature of 40° C. and 50° C.
    Type: Grant
    Filed: October 19, 2001
    Date of Patent: October 28, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Louis S. Crocker, Joseph L. Kukura, II, Andrew S. Thompson, Christine Stelmach, Steven D. Young