Patents by Inventor Christine Taylor Brew

Christine Taylor Brew has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR TREATING CANCER
    Publication number: 20230149415
    Abstract: Methods and compositions for treating cancer are disclosed herein. The methods may comprise use of therapeutically effective amounts of one or more therapeutic agents to cause a difference in expression or activity of protein kinase, membrane associated tyrosine/threonine 1 (PKMYT1) in cancer cells that are deficient in protein phosphatase 2 regulatory subunit B alpha (PPP2R2A).
    Type: Application
    Filed: September 28, 2022
    Publication date: May 18, 2023
    Inventors: Stephen Harrison, Christine Taylor Brew, Michael David Winther, Sourabh Banerjee, Shawn Yost
  • COMPOSITIONS AND METHODS FOR GENERATING SYNTHETIC LETHALITY IN TUMORS
    Publication number: 20230078425
    Abstract: The present disclosure provides methods for treating cancer comprising administering one or more therapeutic agents for manipulation of a target gene (e.g., protein kinase, membrane associated tyrosine/threonine 1 (PKMYT1)), wherein the cancer has a mutation in, an altered (e.g., increased or decreased) expression level and/or an altered activity of a biomarker. Provided herein are methods for identifying biomarkers of the disclosure that form a synthetic lethal pair with a target gene (e.g., PKMYT1).
    Type: Application
    Filed: August 17, 2022
    Publication date: March 16, 2023
    Inventors: Stephen David HARRISON, Michael David WINTHER, Yuanyuan XIAO, Shawn YOST, Christine Taylor BREW, Yaron TURPAZ
  • COMPOSITIONS AND METHODS FOR GENERATING SYNTHETIC LETHALITY IN TUMORS
    Publication number: 20230073494
    Abstract: The present disclosure provides methods for treating cancer comprising administering one or more therapeutic agents for manipulation of a target gene (e.g., protein kinase, membrane associated tyrosine/threonine 1 (PKMYT1)), wherein the cancer has an altered (e.g., increased or decreased) expression level and/or activity of a biomarker. Provided herein are methods for identifying biomarkers of the disclosure that form a synthetic lethal pair with a target gene (e.g., PKMYT1).
    Type: Application
    Filed: August 17, 2022
    Publication date: March 9, 2023
    Inventors: Stephen David HARRISON, Michael David WINTHER, Yuanyuan XIAO, Shawn YOST, Christine Taylor BREW, Yaron TURPAZ
  • METHODS AND COMPOSITIONS FOR TREATING CANCER
    Publication number: 20220356494
    Abstract: The present disclosure provides lethal gene pair targets for cancer treatment, along with methods and compositions for regulating their expression and activity. Gene pairs disclosed herein include tyrosine kinase genes (e.g., SRC, RON, and YES). Also provided are methods and compositions for regulating tyrosine kinase activity, including RON specific pyrazole benzamide inhibitors and methods for gene regulation.
    Type: Application
    Filed: June 17, 2022
    Publication date: November 10, 2022
    Inventors: Tackhoon Kim, Timothy Lu, Stephen Harrison, Christine Taylor Brew, Grace Anderson, Sylvain Baron, Jessie Peh, Shawn Yost, Oliver Purcell, Siting Zhang, Toni Kline
  • POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES
    Publication number: 20190070251
    Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
    Type: Application
    Filed: April 28, 2017
    Publication date: March 7, 2019
    Inventors: Mary J. Bossard, Steven O. Roczniak, Harold Zappe, Yujun Wang, Ping Zhang, Dawei Sheng, C. Simone Jude-Fishburn, Elizabeth Louise Minamitani, Xiaofeng Liu, Haim Moskowitz, Dennis G. Fry, Cherie F. Ali, Christine Taylor Brew
  • METHOD FOR PREDICTING AND EVALUATING RESPONSIVENESS TO CANCER TREATMENT WITH DNA-DAMAGING CHEMOTHERAPEUTIC AGENTS
    Publication number: 20180095085
    Abstract: Provided herein are methods directed to the prediction and early assessment of the efficacy of cancer treatment regimens, in particular in patients undergoing therapy with a DNA-damaging chemotherapeutic agent, by determining expression levels of certain proteins found to be useful as biomarkers in circulating tumor cells obtained from the patient both prior to and post-treatment.
    Type: Application
    Filed: December 7, 2017
    Publication date: April 5, 2018
    Inventors: Ute Hoch, Christine Taylor Brew, Stephen David Harrison, Dennis G. Fry, Darren W. Davis
  • Method for predicting and evaluating responsiveness to cancer treatment with DNA-damaging chemotherapeutic agents
    Patent number: 9863949
    Abstract: Provided herein are methods directed to the prediction and early assessment of the efficacy of cancer treatment regimens, in particular in patients undergoing therapy with a DNA-damaging chemotherapeutic agent, by determining expression levels of certain proteins found to be useful as biomarkers in circulating tumor cells obtained from the patient both prior to and post-treatment.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: January 9, 2018
    Inventors: Ute Hoch, Christine Taylor Brew, Stephen David Harrison, Dennis G. Fry, Darren W. Davis
  • Polymer conjugates of therapeutic peptides
    Patent number: 9682153
    Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: June 20, 2017
    Assignee: Nektar Therapeutics
    Inventors: Mary J. Bossard, Steven O. Roczniak, Harold Zappe, Yujun Wang, Ping Zhang, Dawei Sheng, C. Simone Jude-Fishburn, Elizabeth Louise Minamitani, Xiaofeng Liu, Haim Moskowitz, Dennis G. Fry, Cherie F. Ali, Christine Taylor Brew
  • POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES
    Publication number: 20160022828
    Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
    Type: Application
    Filed: March 20, 2015
    Publication date: January 28, 2016
    Inventors: Mary J. Bossard, Steven O. Roczniak, Harold Zappe, Yujun Wang, Ping Zhang, Dawei Sheng, C. Simone Jude-Fishburn, Elizabeth Louise Minamitani, Xiaofeng Liu, Haim Moskowitz, Dennis G. Fry, Cherie F. Ali, Christine Taylor Brew
  • METHOD FOR PREDICTING AND EVALUATING RESPONSIVENESS TO CANCER TREATMENT WITH DNA-DAMAGING CHEMOTHERAPEUTIC AGENTS
    Publication number: 20140357659
    Abstract: Provided herein are methods directed to the prediction and early assessment of the efficacy of cancer treatment regimens, in particular in patients undergoing therapy with a DNA-damaging chemotherapeutic agent, by determining expression levels of certain proteins found to be useful as biomarkers in circulating tumor cells obtained from the patient both prior to and post-treatment.
    Type: Application
    Filed: May 30, 2014
    Publication date: December 4, 2014
    Applicant: NEKTAR THERAPEUTICS
    Inventors: Ute Hoch, Christine Taylor Brew, Stephen David Harrison, Dennis G. Fry, Darin W. Davis
  • POLYMER CONJUGATES OF OPIOID GROWTH FACTOR PEPTIDES
    Publication number: 20110171165
    Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
    Type: Application
    Filed: September 17, 2009
    Publication date: July 14, 2011
    Inventors: Dennis G. Fry, Christine Taylor Brew, Steven O. Roczniak, Xiaofeng Liu
  • POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES
    Publication number: 20110166063
    Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
    Type: Application
    Filed: September 17, 2009
    Publication date: July 7, 2011
    Applicant: Nektar Therapeutics
    Inventors: Mary J. Bossard, Steven O. Roczniak, Harold Zappe, Yujun Wang, Ping Zhang, Dawei Sheng, C. Simone Jude-Fishburn, Elizabeth Louise Minamitani, Xiaofeng Liu, Haim Moskowitz, Dennis G. Fry, Cherie F. Ali, Christine Taylor Brew