Abstract: The invention relates to novel methods for synthesizing amanitin derivatives having a hydroxy group attached to the central tryptophan moiety. The invention furthermore relates to novel amanitin derivatives having a hydroxy group attached to position 4?, 5? or 7? of the central tryptophan moiety, novel conjugates of such amanitin derivatives, and pharmaceutical compositions comprising such conjugates.

Abstract: A wastegate assembly for controlling flow of exhaust gas includes a valve element having a valve body and a valve shaft. The wastegate assembly further includes a spindle. The wastegate assembly further includes a washer coupled to the valve shaft and spaced from the spindle for securing the spindle to the valve shaft. A plurality of cup springs is disposed between the spindle and the washer. The plurality of cup springs includes at least a first cup spring and a second cup spring, with the first cup spring supported on the spindle head and the second cup spring orientated substantially identical to the first cup spring and disposed directly on the first cup spring.

Abstract: The present invention relates to an amatoxin-linker construct comprising an amatoxin according to formula (I) wherein: R1 and R2 are each —OH, R3 is NH2, or a linker which carries a reactive group Y for linking said amatoxin to a target-binding moiety, R4 is H or a linker which carries a reactive group Y for linking said amatoxin to a target-binding moiety, R5 is absent or ?O, wherein R3 and R4 cannot be the same, for use in the manufacture of a binding moiety-toxin conjugate for the treatment of a solid tumor, and a respective binding moiety-toxin conjugate for the treatment of a solid tumor.

Abstract: The invention relates to novel methods for synthesizing amanitin derivatives having an amino group attached to position 6? of the central tryptophan moiety. The invention furthermore relates to a novel amanitin derivative having an amino group attached to position 6? of the central tryptophan moiety, novel conjugates of such amanitin derivative, and pharmaceutical compositions comprising such conjugates.

Abstract: A method and device for the synchronization of processes, a first signal being sent by a clock-giving processor, the first signal having, in an alternating manner, first edges having a first direction and second edges having a second direction opposite the first edge, a temporal distance between at least one of the first edges and at least one of the second edges being determined as a function of a state of a counter in the clock-giving processor. A method for the synchronization of processes, a first signal being received by a clock-receiving processor, the first signal having, in an alternating manner, first edges having a first direction and second edges having a second direction opposite the first edge, a state of a counter in the clock-receiving processor being determined as a function of a temporal distance between at least one of the first edges and at least one of the second edges.

Abstract: Amatoxins, as well as antibody-drug conjugates (ADCs) comprising an amatoxin are provided, as well as compositions and methods of using the same. The compositions and methods provided herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy and to improve the engraftment of hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant procedure. Methods and compositions for the treatment of various hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, as well as prevention of graft-versus-host-disease (GVHD), are provided.

Abstract: The invention elates to a method for operating a transversal guidance system of a motor vehicle through two independent channels to perform automatic transversal guidance interventions. Through the first channel, transversal interventions are performed via a first transversal guidance actuator controlled by means of a driver-operated steering handle. Through the second channel, a vehicle system sets a target, roll angle, and a second transversal guidance actuator is controlled by a transversal guidance system that performs a transversal guidance intervention based on the roll angle. The vehicle system displays the roll angle as a notification to the driver of the transversal guidance intervention. The invention also relates to a motor vehicle configured to perform the method.

Abstract: The invention relates to conjugates comprising amatoxins and antibodies, in particular amatoxins linked to antibodies comprising specific cysteine residues.

Abstract: An arrangement of a microlithographic imaging device, such as one that operates in the EUV range, includes a holding device for holding an optical element. The optical element includes an optical surface and defines a plane of main extension, in which the optical element defines a radial direction and a circumferential direction. The holding device includes a base unit and more than three separate holding units. The base unit includes a plurality of support interface units, which are spaced apart from one another in the circumferential direction, for connecting the holding device to a support structure. The holding units are connected to the base unit and distributed along the circumferential direction and spaced apart from one another. The holding units hold the optical element with respect to the base unit.

Abstract: The invention relates to a PSMA-targeting conjugate comprising (a) an amatoxin; (b) a small molecule PSMA-targeting moiety; and (c) optionally a linker linking said amatoxin and said small molecule PSMA-targeting moiety. The invention furthermore relates to a pharmaceutical composition comprising such conjugate.

Abstract: An exemplary fill level measurement device comprising a radar module can be provided, along with method, computer-executable instructions and computer-readable medium. The radar module can comprise a receiving channel for receiving a radar signal reflected by a filling medium. The fill level measurement device can also comprise a test module for testing the functionality of the receiving channel. The test module can comprise a test input (for feeding in a test signal having a test frequency, and a feeding-in apparatus configured to feed at least part of the test signal into the receiving channel. The feeding-in apparatus can be configured to superpose and/or combine the test signal with the radar signal reflected by the filling medium. The receiving channel of the radar module can further comprise a mixing device having an intermediate frequency output.

Abstract: A radar fill level measurement device can be provided, which comprises a frequency synthesizer configured to generate an oscillator signal, a high-frequency signal generation module configured to generate a transmission signal based on the oscillator signal, and an energy-supply module configured to supply electrical energy to the frequency synthesizer and the high-frequency signal generation module. Associated methods and computer-accessible medium can also be provided. The frequency synthesizer can comprise a control device, a reference oscillator and a phase-locked loop. The phase-locked loop can comprise a phase-locked device and an oscillator. The phase-locked loop can be configured to adjust a frequency of the oscillator signal to a target value, and the phase-locked device can be configured to provide a control signal for the control device when the frequency of the oscillator signal has reached the target value.

Abstract: A passive current sensor includes a pair of electrically conductive busbars, a shunt resistor electrically connecting the busbars, and a support having a first pair of voltage drop measuring contacts. At least one of the voltage drop measuring contacts is attached to each of the busbars and forms a direct electrical contact between the at least one voltage drop measuring contact and the busbar.

Abstract: A radar module for level and/or limit level monitoring in plant automation, comprising a radar signal source that generates and transmit a radar signal, the radar signal source having a surface facing a filling material, a radar signal conductor that receives, conducts and emits the radar signal, the radar signal conductor being mounted on the surface of the radar signal source, and a potting compound that at least partially covers the surface of the radar signal source and at least partially covers the radar signal conductor.

Abstract: An optical arrangement of an imaging device for microlithography, particularly for using light in the extreme UV range, includes an optical element and a holding device for holding the optical element. The optical element includes an optical surface and defines a plane of main extension, in which the optical element defines a radial direction and a circumferential direction. The holding device includes a base element and more than three separate holding units. The holding units are connected to the base element and arranged in a manner distributed along the circumferential direction and spaced apart from one another. The holding units hold the optical element with respect to the base element. Each of the holding units establishes a clamping connection between the optical element and the base element. The clamping connection for each holding unit is separate from the clamping connections of the other holding units.

Abstract: The invention relates to ?-amaninamide (1; x=0, 1 or 2), ?-amaninamidic acid (2; x=0, 1 or 2), and ?-amaninamidic hydroxamic acid (3; x=0, 1 or 2), novel derivatives of ?-amanitin (4), and methods and novel building blocks for the synthesis thereof.

Abstract: The invention relates to novel methods for synthesizing amanitin derivatives having a hydroxy group attached to the central tryptophan moiety. The invention furthermore relates to novel amanitin derivatives having a hydroxy group attached to position 4?, 5? or 7? of the central tryptophan moiety, novel conjugates of such amanitin derivatives, and pharmaceutical compositions comprising such conjugates.

Abstract: The present invention is directed towards aqueous formulations comprising (A) at least one alkoxylated polypropylenimine, (B) at least one non-ionic surfactant, selected from (B1) alkyl polyglycosides and (B2) alkoxylated C8-C14-Guerbet alcohols.

Abstract: A blockchain integration layer uses mappings, for each blockchain of a plurality of blockchains, to integrate blockchain data into a database. A user interface may be presented that allows a user to view the blockchain data from the database, create data for the blockchain in the database, or both. Based on the created data for the blockchain in the database, the blockchain integration layer may modify the blockchain to store the created data. Standardized mappings are used to define the transformations to be used to convert data stored in blockchain blocks into a usable format for external systems. A set of JavaScript object notation (JSON) objects, one for each supported message type, may be used to define the set of transformations to support a blockchain. Using multiple sets of JSON objects, the blockchain integration layer integrates multiple blockchains with the external systems.

Abstract: A printed circuit board for a radar level measurement device with a printed circuit board substrate is provided, wherein a microwave signal is coupled via a microwave conductor into a waveguide. A connection region on a front side of the printed circuit board substrate serves to receive the waveguide. A shape of a resonator shell is generated inversely by producing an annular peripheral recess whose wall has an electromagnetically reflecting coating on a rear side of the printed circuit board substrate. The annular peripheral recess on the rear side, together with a region surrounded by the recess, forms a resonator for the injected microwave signals.