Patents by Inventor Christoph Rose-Petruck
Christoph Rose-Petruck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11930581Abstract: A modular laser-produced plasma X-ray system includes a liquid metal flow system enclosed within a low-pressure chamber, the flow system including a liquid metal, wherein in at least one location on the liquid metal forms a metal target directly illuminated by laser pulses, a circulation pump within the liquid metal flow system for circulating the liquid metal, a laser pulse emitter configured to transmit laser pulses into the chamber via a laser window, focusing optics, located between the emitter and the metal target, the focusing optics directing the laser pulses to strike the metal target at a target location to form X-ray pulses, and an X-ray window positioned within the chamber to enable the X-ray pulses to exit the chamber.Type: GrantFiled: April 28, 2022Date of Patent: March 12, 2024Assignees: Brown University, Research Instruments CorporationInventors: Daniel John DeCiccio, Christoph Rose-Petruck
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Publication number: 20220256681Abstract: A modular laser-produced plasma X-ray system includes a liquid metal flow system enclosed within a low-pressure chamber, the flow system including a liquid metal, wherein in at least one location on the liquid metal forms a metal target directly illuminated by laser pulses, a circulation pump within the liquid metal flow system for circulating the liquid metal, a laser pulse emitter configured to transmit laser pulses into the chamber via a laser window, focusing optics, located between the emitter and the metal target, the focusing optics directing the laser pulses to strike the metal target at a target location to form X-ray pulses, and an X-ray window positioned within the chamber to enable the X-ray pulses to exit the chamber.Type: ApplicationFiled: April 28, 2022Publication date: August 11, 2022Inventors: Daniel John DeCiccio, Christoph Rose-Petruck
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Patent number: 11330697Abstract: A laser-produced plasma X-ray system includes a liquid metal flow system enclosed within a low-pressure chamber, the flow system including a liquid metal, wherein in at least one location on the liquid metal forms a metal target beam, a circulation pump within the flow system for circulating the liquid metal, a laser pulse emitter configured to transmit a plurality of laser pulses into the chamber via a laser window, focusing optics, located between the emitter and the metal target beam, the focusing optics directing the laser pulses to strike the metal target beam at a target location to form X-ray pulses, and an X-ray window positioned within the chamber to allow the X-ray pulses to exit the chamber.Type: GrantFiled: December 27, 2017Date of Patent: May 10, 2022Assignees: Brown University, Research Instruments CorporationInventor: Christoph Rose-Petruck
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Patent number: 11324103Abstract: A modular laser-produced plasma X-ray system includes a liquid metal flow system enclosed within a low-pressure chamber, the flow system including a liquid metal, wherein in at least one location on the liquid metal forms a metal target directly illuminated by laser pulses, a circulation pump within the liquid metal flow system for circulating the liquid metal, a laser pulse emitter configured to transmit laser pulses into the chamber via a laser window, focusing optics, located between the emitter and the metal target, the focusing optics directing the laser pulses to strike the metal target at a target location to form X-ray pulses, and an X-ray window positioned within the chamber to enable the X-ray pulses to exit the chamber.Type: GrantFiled: December 27, 2017Date of Patent: May 3, 2022Assignees: Research Instruments Corporation, Brown UniversityInventors: Daniel John DeCiccio, Christoph Rose-Petruck
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Patent number: 10833374Abstract: A method and apparatus for in-situ x-ray scatter imaging of battery electrodes. An apparatus includes an X-ray source, a grid, the grid comprising stainless steel wires with uniform spacing, and a cell, the X-ray source directing a beam of energy through the metal grid and components of the cell, the cell blurring a previously sharp projection of grid wires on an image detector. A method includes providing a Spatial Frequency Heterodyne Imaging system, providing a grid, providing a cell, generating X-rays from the Spatial Frequency Heterodyne Imaging system that pass through components of the cell and the grid, and detecting a scatter image from the X-rays.Type: GrantFiled: November 3, 2017Date of Patent: November 10, 2020Assignee: BROWN UNIVERSITYInventors: Christoph Rose-Petruck, Brian Sheldon, Alexandra Stephan, Ravi Kumar, Francicso Schunk
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Patent number: 10307527Abstract: Systems, compositions, methods and kits employ protein shells, such as ferritin or viral capsid shells, herein called nanobubbles, to enhance X-ray images of cells or body tissue under certain x-ray imaging methods. The nanobubbles have sub-micron size such as about 10 nm, about 40, 60, or 100 nm and may be functionalized for effective delivery to or uptake by a target tissue, in vivo or a cell culture. The nanobubbles are hollow, having a central core which may be empty or contain a fluid, such that the shells effectively form long-lived bubbles in the imaged environment, and are of low electron density and have different scattering properties than the surrounding tissue. X-ray imaging by spatial frequency heterodyne imaging enhances visualization or detection of tissue regions bearing the shells. The protein shells may be further treated to assure biocompatibility and/or to resist undesired interactions with non-targeted tissue, such as scavenging by the liver, or attack by the immune system.Type: GrantFiled: April 21, 2015Date of Patent: June 4, 2019Assignees: Brown University, Montana State UniversityInventors: Christoph Rose-Petruck, Trevor Douglas, Danielle Rand, Masaki Uchida
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Publication number: 20180206318Abstract: A modular laser-produced plasma X-ray system includes a liquid metal flow system enclosed within a low-pressure chamber, the flow system including a liquid metal, wherein in at least one location on the liquid metal forms a metal target directly illuminated by laser pulses, a circulation pump within the liquid metal flow system for circulating the liquid metal, a laser pulse emitter configured to transmit laser pulses into the chamber via a laser window, focusing optics, located between the emitter and the metal target, the focusing optics directing the laser pulses to strike the metal target at a target location to form X-ray pulses, and an X-ray window positioned within the chamber to enable the X-ray pulses to exit the chamber.Type: ApplicationFiled: December 27, 2017Publication date: July 19, 2018Inventors: Daniel John DeCiccio, Christoph Rose-Petruck
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Publication number: 20180206319Abstract: A laser-produced plasma X-ray system including a liquid metal flow system enclosed within a low-pressure chamber, the flow system including a liquid metal, wherein in at least one location on the liquid metal forms a metal target beam, a circulation pump within the flow system for circulating the liquid metal, a laser pulse emitter configured to transmit a plurality of laser pulses into the chamber via a laser window, focusing optics, located between the emitter and the metal target beam, the focusing optics directing the laser pulses to strike the metal target beam at a target location to form X-ray pulses, and an X-ray window positioned within the chamber to allow the X-ray pulses to exit the chamber, wherein the laser pulses prevent debris from accumulating on the laser window.Type: ApplicationFiled: December 27, 2017Publication date: July 19, 2018Inventor: Christoph Rose-Petruck
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Publication number: 20180206320Abstract: A laser-produced plasma X-ray system includes a liquid metal flow system enclosed within a low-pressure chamber, the flow system including a liquid metal, wherein in at least one location on the liquid metal forms a metal target beam, a circulation pump within the flow system for circulating the liquid metal, a laser pulse emitter configured to transmit a plurality of laser pulses into the chamber via a laser window, focusing optics, located between the emitter and the metal target beam, the focusing optics directing the laser pulses to strike the metal target beam at a target location to form X-ray pulses, and an X-ray window positioned within the chamber to allow the X-ray pulses to exit the chamber,Type: ApplicationFiled: December 27, 2017Publication date: July 19, 2018Inventor: Christoph Rose-Petruck
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Publication number: 20180131044Abstract: A method and apparatus for in-situ x-ray scatter imaging of battery electrodes. An apparatus includes an X-ray source, a grid, the grid comprising stainless steel wires with uniform spacing, and a cell, the X-ray source directing a beam of energy through the metal grid and components of the cell, the cell blurring a previously sharp projection of grid wires on an image detector.Type: ApplicationFiled: November 3, 2017Publication date: May 10, 2018Inventors: Christoph Rose-Petruck, Brian Sheldon, Alexandra Stephan, Ravi Kumar, Francicso Schunk
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Publication number: 20160274086Abstract: Methods, compositions, systems, devices and kits are provided herein for preparing and using a nanoparticle composition and spatial frequency heterodyne imaging for visualizing cells or tissues. In various embodiments, the nanoparticle composition includes at least one of: a nanoparticle, a polymer layer, and a binding agent, such that the polymer layer coats the nanoparticle and is for example a polyethylene glycol, a polyelectrolyte, an anionic polymer, or a cationic polymer, and such that the binding agent that specifically binds the cells or the tissue. Methods, compositions, systems, devices and kits are provided for identifying potential therapeutic agents in a model using the nanoparticle composition and spatial frequency heterodyne imaging.Type: ApplicationFiled: April 1, 2016Publication date: September 22, 2016Applicants: Brown University, Rhode Island HospitalInventors: Christoph Rose-Petruck, Jack R. Wands, Danielle Rand, Zoltan Derdak, Vivian Ortiz
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Patent number: 9316645Abstract: Methods, compositions, systems, devices and kits are provided herein for preparing and using a nanoparticle composition and spatial frequency heterodyne imaging for visualizing cells or tissues. In various embodiments, the nanoparticle composition includes at least one of: a nanoparticle, a polymer layer, and a binding agent, such that the polymer layer coats the nanoparticle and is for example a polyethylene glycol, a polyelectrolyte, an anionic polymer, or a cationic polymer, and such that the binding agent that specifically binds the cells or the tissue. Methods, compositions, systems, devices and kits are provided for identifying potential therapeutic agents in a model using the nanoparticle composition and spatial frequency heterodyne imaging.Type: GrantFiled: October 5, 2012Date of Patent: April 19, 2016Assignees: BROWN UNIVERSITY, RHODE ISLAND HOSPITALInventors: Christoph Rose-Petruck, Jack R. Wands, Danielle Rand, Zoltan Derdak, Vivian Ortiz
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Patent number: 9234285Abstract: A method of using clathrate hydrates (including ammonia clathrates), in electrochemical transformations. Noted are converting clathrate guest molecules such as CO2, CH4, alkanes, and alkenes; and, optionally, the use of clathrates-promoting molecules such as tetra hydro furan, to produce higher value carbon molecules including propane and formic acid.Type: GrantFiled: January 13, 2015Date of Patent: January 12, 2016Assignee: Brown UniversityInventors: Christoph Rose-Petruck, G. Tayhas R. Palmore, Daniel DeCiccio, Steven Ahn
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Publication number: 20150297756Abstract: Systems, compositions, methods and kits employ protein shells, such as ferritin or viral capsid shells, herein called nanobubbles, to enhance X-ray images of cells or body tissue under certain x-ray imaging methods. The nanobubbles have sub-micron size such as about 10 nm, about 40, 60, or 100 nm and may be functionalized for effective delivery to or uptake by a target tissue, in vivo or a cell culture. The nanobubbles are hollow, having a central core which may be empty or contain a fluid, such that the shells effectively form long-lived bubbles in the imaged environment, and are of low electron density and have different scattering properties than the surrounding tissue. X-ray imaging by spatial frequency heterodyne imaging enhances visualization or detection of tissue regions bearing the shells. The protein shells may be further treated to assure biocompatibility and/or to resist undesired interactions with non-targeted tissue, such as scavenging by the liver, or attack by the immune system.Type: ApplicationFiled: April 21, 2015Publication date: October 22, 2015Inventors: Christoph Rose-Petruck, Trevor Douglas, Danielle Rand, Masaki Uchida
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Publication number: 20150203972Abstract: A method of using clathrate hydrates (including ammonia clathrates), in electrochemical transformations. Noted are converting clathrate guest molecules such as CO2, CH4, alkanes, and alkenes; and, optionally, the use of clathrates-promoting molecules such as tetra hydro furan, to produce higher value carbon molecules including propane and formic acid.Type: ApplicationFiled: January 13, 2015Publication date: July 23, 2015Inventors: Christoph Rose-Petruck, G. Tayhas R. Palmore, Daniel DeCiccio, Steven Ahn
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Publication number: 20050228271Abstract: The presence of a mechanical disturbance, such as an ultrasonic field, within a body can alter an x-ray image of the body in a way that can enhance its diagnostic capabilities. In the first mode of operation of the invention an acoustic field causes displacement within the body through radiation forces detected by recording two x-ray images, one image with the sonic field on and a second image with the sonic field off. Each image is stored in a computer memory, and the images are digitally subtracted, pixel by pixel, to yield a differential image. In the second mode of operation of the invention, the sonic field is a standing or traveling acoustic wave within the body. An image is recorded with bursts of pulsed x-rays where the bursts are produced synchronously with the mechanical disturbance. The method makes the x-ray sensitive to differences in tissue sound speed or stiffness so that it acquires an additional contrast mechanism.Type: ApplicationFiled: April 6, 2004Publication date: October 13, 2005Inventors: Gerald Diebold, Christoph Rose-Petruck