Abstract: A process for producing a solid dispersion of an active ingredient which comprises feeding the active ingredient and a matrix-forming agent to an extruder and forming a uniform extrudate, wherein the extruder comprises at least two rotating shafts (2), each of the shafts (2) carrying a plurality of processing elements disposed axially one behind the other, the processing elements defining (i) a feeding and conveying section (A), (ii) at least one mixing section (B), and (iii) a discharging section (E), wherein the processing element(s) defining the mixing section (B) comprise(s) a mixing element (11, 12, 13) that is derived from a screw type element (FIG. 2).

Abstract: A process for producing a solid dispersion of an active ingredient which comprises feeding the active ingredient and a matrix-forming agent to an extruder and forming a uniform extrudate, wherein the extruder comprises at least two rotating shafts (2), each of the shafts (2) carrying a plurality of processing elements disposed axially one behind the other, the processing elements defining (i) a feeding and conveying section (R; A), (ii) at least one reverse-flight section (D), and (iii) a discharging section (E), wherein the processing elements defining the reverse-flight section (R; D) comprise at least one reverse-flight element (14) which is based on a screw-type element having a conveying direction being opposite to the general conveying direction of the extruder.

Abstract: The invention relates to a process for operating a cash box (10), in which in a memory element (18) of a control unit (14) of the cash box (10) program data of a production bootstrap loader for booting the cash box (10) and a production key (P) for encrypting data sent by the cash box (10) and/or for decrypting received data are factory-stored. For commencing operation the cash box (10) is inserted in a device (30, 54, 62, 72) for receiving cash boxes (10). A data transmission connection is established to the cash box (10). The program data of the production bootstrap loader are replaced by program data of an operation bootstrap loader for booting the cash box (10) and the production key (P) is replaced by a client-specific operation key (A, B, C, D).

Abstract: A gas mask is provided with a mask body, which is designed to cover the face of a user, and with an opening in the mask body, which is closed by a speech diaphragm (8) in a gas-tight manner. A funnel (4) is directed toward the speech diaphragm with an opening angle in the range of 20° to 90°. The funnel (4) is arranged in front of the speech diaphragm in the interior space of the mask body in order to focus sound waves onto the speech diaphragm.

Abstract: The present invention relates to nitric oxide releasing compounds and their use in the prevention, amelioration and/or therapy of nitric oxide (NO) deficiency induced disturbances of the cerebral microcirculation. The NO deficiency induced disturbances of the cerebral microcirculation may be due to an intracranial hemorrhage or stroke and can cause cerebrovascular spasms (or cerebral vasospasms) (CVS) and/or malperfusion of brain parenchyma caused by blood vessel and blood flow dysregulation which, in turn, can cause secondary neurological deficiencies (DIND) and/or brain infarction. Particularly, the present invention relates to the prevention, amelioration and/or therapy of delayed cerebral vasospasm-associated disorders after survived subarachnoidal hemorrhage by applying a NO-donor, most preferably Molsidomine.

Abstract: A traffic information system includes first vehicles equipped with first optical sensor means. An image of an environment of the first vehicles is generated with the first optical sensor means and includes as associated image attributes: a current position of the first vehicles at which the image was generated, a time at which the image was generated, and a viewing direction with which the image was generated. The image and the associated image attributes of the environment of the first vehicles are communicated to a network and the image and the associated image attributes are at least buffered in the network. A second vehicle comprises a utilisation device that includes an input means and a display means. An image relating to a position POI in a road transport network is retrieved via the utilisation device from the network and the image is displayed on the display means.

Abstract: An electric heater is provided that includes at least two groups of heating elements which change their temperature by electrical power consumption, comprising a control unit with two switch arrangements such that the first switch arrangement includes at least two power switches for switching the at least two groups of heating elements in a High-side connection and such that the second power switch arrangement includes at least two switches for switching the at least two groups of heating elements in a Low-side connection.

Abstract: The present invention relates to inorganic spherical pigments which are based on spherical particles having a particle diameter of 0.1-100 ?m and are coated on the surface with agglomerates selected from the group ZrO2, ZnO, Al2O3, TiO2, Fe2O3, Fe3O4, FeOOH and BaSO4 or mixtures thereof, and are optionally coated with a further layer (2nd layer) comprising a metal oxide, lake or Berlin Blue, and to the use thereof in paints, coatings, printing inks, security printing inks, plastics, ceramic materials, glasses, in cosmetic formulations, as tracer, as filler and for the preparation of pigment preparations and dry preparations.

Abstract: The present invention relates to recombinant factor H and variants and conjugates thereof and methods of their production, as well as uses and methods of treatment involving the materials.

Abstract: The present invention relates to a method for operating a predictive adaptive front lighting for a vehicle with headlamps and a controller. The method includes the steps of receiving a vehicle position; identifying a map location of the vehicle; determining a most likely path of the vehicle based on the map location; locating a target point on the most likely path of the vehicle; adaptively changing a distance between the vehicle and the target point; calculating a desired swivel angle for the vehicle headlamps based on the most likely path of the vehicle; and swiveling the headlamps according to the desired swivel angle.

Abstract: The present invention relates to a method for the characterisation of pigments and fillers in which the luminance of a pigmented transparent medium is determined against a dark background. This measurement method is particularly suitable for determining the optical properties of cosmetic fillers.

Abstract: Tool holding systems described herein include a tool holder configured to releasably retain a metal-processing tool and to define a tool holder passage extending along a stroke axis, an adjustment drive operable to rotate the tool holder about the stroke axis, and a stroke drive including a spindle operable independent of the adjustment drive to translate the tool holder along the stroke axis. The stroke drive defines a stroke drive passage cooperating with the tool holder passage to define a waste disposal passageway through the tool holding system.

Abstract: A motor vehicle and a method for controlling a motor vehicle in road traffic are provided. A motor vehicle includes a driver assistance system and a navigation means comprising a sensor for detecting compressive forces, or tensile forces, or torsional forces. An evaluation unit is coupled to the navigation means and evaluates the signals of the sensor. The evaluation unit puts the driver assistance system into operation or takes it out of operation when a threshold value of the signals stored in the evaluation unit is exceeded or fallen below. A controller is activated when the threshold value is exceeded or fallen below and transfers at least partial control of the motor vehicle by the driver assistance system to manual operation by a driver or transfers the manual control of the motor vehicle to at least partial control by the driver assistance system.

Abstract: Compositions and methods of making the same for in vivo delivery of lixivaptan to a subject in need thereof are described. The composition includes a substantially water-insoluble pharmacologically active agent (e.g., lixivaptan) and a substantially water-insoluble matrix forming material (e.g., a Vitamin E semi-ester), wherein the pharmacologically active agent is dispersed in said matrix forming material, and wherein the composition delivers said substantially water-insoluble pharmacologically active agent upon exposure to physiological medium.

Abstract: An apparatus for determining an amount of rotation of a rotatable component that rotates with respect to a stationary component. The apparatus includes a cable with a first end fixed to the rotatable component and a second end fixed to the stationary component. The cable, which supports a sensing element, is configured to wind or unwind when the rotatable component rotates with respect to the stationary component. The sensing element extends along a length of the cable and is configured to flex in response to the winding or unwinding of the cable. The sensing element has a resistance that changes in response to flexion of the sensing element. An evaluation circuit is connected to the sensing element and is configured to determine a value having a relation to the resistance and determine the amount of rotation based on the value.

Abstract: A fuel pump, including at least one driven impeller made of plastic, which rotates in a pump housing and on the sides having guide blades that each delimit at least one ring of blade chambers, and further having partial ring-shaped channels arranged on both sides in the region of the guide blades in the pump housing, said channels forming delivery chambers with the blade chambers for delivering fuel. An inlet channel leads into the one delivery chamber and the other delivery chamber leads into an outlet channel and the impeller contains carbon fibers embedded in the plastic.

Abstract: In some aspects of the disclosure, a workpiece retention device for securing plate-like workpieces to a workpiece movement unit of a machine tool includes first and second workpiece clamping elements and a clamping drive by which the workpiece clamping elements can be moved towards one another starting from an initial relative position in order to clamp a workpiece that is arranged between the workpiece clamping elements. The workpiece retention device also includes an adjustment device that can adjust the initial relative position of the workpiece clamping elements.

Abstract: The present invention relates to a method for operating a predictive adaptive front lighting for a vehicle with headlamps and a controller. The method includes the steps of receiving a vehicle position; identifying a map location of the vehicle; determining a most likely path of the vehicle based on the map location; locating a target point on the most likely path of the vehicle; adaptively changing a distance between the vehicle and the target point; calculating a desired swivel angle for the vehicle headlamps based on the most likely path of the vehicle; and swiveling the headlamps according to the desired swivel angle.

Abstract: Tool holding systems described herein include a tool holder configured to releasably retain a metal-processing tool and to define a tool holder passage extending along a stroke axis, an adjustment drive operable to rotate the tool holder about the stroke axis, and a stroke drive including a spindle operable independent of the adjustment drive to translate the tool holder along the stroke axis. The stroke drive defines a stroke drive passage cooperating with the tool holder passage to define a waste disposal passageway through the tool holding system.

Abstract: Tool holding systems described herein include a tool holder configured to releasably retain a metal-processing tool and to define a tool holder passage extending along a stroke axis, an adjustment drive operable to rotate the tool holder about the stroke axis, and a stroke drive including a spindle operable independent of the adjustment drive to translate the tool holder along the stroke axis. The stroke drive defines a stroke drive passage cooperating with the tool holder passage to define a waste disposal passageway through the tool holding system.