Patents by Inventor Christoph Stein
Christoph Stein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11959802Abstract: A spectrometer device includes an optical interference filter which is designed to filter specific wavelength ranges of an incident light beam on passage through the optical interference filter. The spectrometer device also includes a detector device which is designed to detect the filtered light beam. Further, the spectrometer device includes a focusing device with a reflective surface. The focusing device is designed to focus the filtered light beam onto the detector device by reflection on the surface.Type: GrantFiled: December 6, 2019Date of Patent: April 16, 2024Assignee: Robert Bosch GmbHInventors: Ralf Noltemeyer, Martin Husnik, Eugen Baumgart, Marc Schmid, Reinhold Roedel, Benedikt Stein, Christoph Schelling, Christoph Daniel Kraemmer
-
Publication number: 20240116846Abstract: The present invention relates to a process for the preparation of mixed polyol-carboxylic acid esters having a molecular weight of greater than or equal to 200 g/mol and less than or equal to 1000 g/mol, wherein a polyol is reacted in an at least two-step reaction with different monocarboxylic acids in the form of monocarboxylic acids or of monocarboxylic acid anhydrides, wherein the different monocarboxylic acids are reacted with the polyol in the order of their reactivity in the esterification reaction, starting with the lowest reactivity, wherein the monocarboxylic acids with the lower reactivity are reacted at least partly as monocarboxylic acid anhydride and the monocarboxylic acid with the highest reactivity is reacted thereafter as monocarboxylic acid with the polyol. Furthermore, the present invention relates to the use of the process for the preparation of mixed polyol esters.Type: ApplicationFiled: January 27, 2022Publication date: April 11, 2024Inventors: Christoph BALZAREK, Eduard RAIS, Jens KUBITSCHKE, Roswitha STEIN, Julia ZIMMERER, Alessa HINZMANN
-
Patent number: 11946805Abstract: A spectrometer apparatus is disclosed that includes at least one light source for irradiating a sample with light, an optical detection device for detecting light scattered by the sample, at least one optical filter device, which is arranged in front of and/or behind the sample, a contact sensor device for determining a contact between the sample and the spectrometer apparatus and for outputting a corresponding output signal, a control device for controlling the light source and the detection device in response to the output signal. The control device is designed such that the control device modifies at least one operating parameter of the light source and the detection device, when the output signal indicates the contact between the sample and the spectrometer apparatus. A method for operating a spectrometer apparatus is disclosed as well.Type: GrantFiled: November 11, 2019Date of Patent: April 2, 2024Assignee: Robert Bosch GmbHInventors: Thomas Buck, Martin Husnik, Christian Huber, Marc Schmid, Benedikt Stein, Christoph Daniel Kraemmer
-
Patent number: 11253599Abstract: The invention relates to the field of analgesics. According to the invention, a kit or composition, particularly a pharmaceutical composition or a pharmaceutical kit, is provided, comprising a nanocarrier which is a hyperbranched polymer, such as a dendritic polymer or dendrimer, preferably having a molecular weight of 1,000-100,000 g/mol, and an analgesic which, when administered without nanocarrier, has both peripheral and central analgesic effect, preferably an opioid such as nalbuphine. According to the invention, the analgesic in this composition mainly or exclusively has a peripheral effect and thus reduces side effects triggered by the activation of central or intestinal opioid receptors. It is used for the treatment of peripheral pain and/or inflammation. The invention also relates to particularly suitable nanocarriers.Type: GrantFiled: December 8, 2016Date of Patent: February 22, 2022Assignee: DendroPharm GmbHInventors: Emanuel Fleige, Sam Moré, Michael Unbehauen, Rainer Haag, Christoph Stein, Halina Machelska-Stein, Florian Paulus
-
Patent number: 10668147Abstract: Complexes suitable for targeting and killing a human target cell comprising a first polypeptide with a binding structure for binding the complex to the cellular surface receptor CD89 (e.g. with an anti CD89 antibody) presented on the cell surface of the human target cell and a second polypeptide comprising a toxic effector domain, preferably Pseudomonas exotoxin A); to nucleic acid molecules encoding said complexes, vectors, host cells containing the nucleic acids and methods for preparation and producing such complexes; compositions and methods for using said complexes for the treatment of diseases, in particular of cancer diseases like leukemia.Type: GrantFiled: March 25, 2015Date of Patent: June 2, 2020Assignees: FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V., RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHENInventors: Christoph Stein, Radoslav Mladenov, Bernhard Stockmeyer, Stefan Barth, Lea Christin Schenke, Rainer Fischer
-
Publication number: 20180344857Abstract: The invention relates to the field of analgesics. According to the invention, a kit or composition, particularly a pharmaceutical composition or a pharmaceutical kit, is provided, comprising a nanocarrier which is a hyperbranched polymer, such as a dendritic polymer or dendrimer, preferably having a molecular weight of 1,000-100,000 g/mol, and an analgesic which, when administered without nanocarrier, has both peripheral and central analgesic effect, preferably an opioid such as nalbuphine. According to the invention, the analgesic in this composition mainly or exclusively has a peripheral effect and thus reduces side effects triggered by the activation of central or intestinal opioid receptors. It is used for the treatment of peripheral pain and/or inflammation. The invention also relates to particularly suitable nanocarriers.Type: ApplicationFiled: December 8, 2016Publication date: December 6, 2018Inventors: Emanuel Fleige, Sam Moré, Michael Unbehauen, Rainer Haag, Christoph Stein, Halina Machelska-Stein, Florian Paulus
-
Publication number: 20180050102Abstract: Complexes suitable for targeting and killing a human target cell comprising a first polypeptide with a binding structure for binding the complex to the cellular surface receptor CD89 (e.g. with an anti CD89 antibody) presented on the cell surface of the human target cell and a second polypeptide comprising a toxic effector domain, preferably Pseudomonas exotoxin A); to nucleic acid molecules encoding said complexes, vectors, host cells containing the nucleic acids and methods for preparation and producing such complexes; compositions and methods for using said complexes for the treatment of diseases, in particular of cancer diseases like leukemia.Type: ApplicationFiled: March 25, 2015Publication date: February 22, 2018Inventors: Christoph Stein, Radoslav Mladenov, Bernhard Stockmeyer, Stefan Barth, Lea Christin Hein, Rainer Fischer
-
Patent number: 9194034Abstract: A pre-coated plate of steel is heated in a furnace to form an intermetallic alloying layer on the plate at least in an area thereof. Air is pretreated through drying to produce dried air which is fed into the furnace to control the atmosphere within the furnace while the pre-coated plate is in the furnace.Type: GrantFiled: September 17, 2012Date of Patent: November 24, 2015Assignee: BENTELER AUTOMOBIL TECHNIK GmbHInventors: Christoph Steins, Matthias Rode, Markus Pellmann, Karsten Bake, Christian Hielscher
-
Patent number: 9133120Abstract: The invention relates to fluorinated fentanyl derivatives that function as opioid receptor agonists, which activate target opioid receptors in a pH-dependent manner, and are thus selective for the receptors in inflamed (acidic) milieu; uses thereof and pharmaceutical compositions comprising them.Type: GrantFiled: August 17, 2012Date of Patent: September 15, 2015Assignees: CHARITÉ—UNIVERSITÄTSMEDIZIN BERLIN, KONRAD-ZUSE-INSTITUTInventors: Christoph Stein, Marcus Weber, Christian Zöllner, Olga Scharkoi
-
Publication number: 20140364449Abstract: The invention relates to a method for identifying compounds that bind and preferably activate a target opioid receptor in a pH-dependent manner.Type: ApplicationFiled: January 7, 2013Publication date: December 11, 2014Applicant: MATHPHARM GMBHInventors: Christoph Stein, Marcus Weber, Olga Scharkol, Peter Deuflhard
-
Publication number: 20140228406Abstract: The invention relates to fluorinated fentanyl derivatives that function as opioid receptor agonists, which activate target opioid receptors in a pH-dependent manner, and are thus selective for the receptors in inflamed (acidic) milieu; uses thereof and pharmaceutical compositions comprising them.Type: ApplicationFiled: August 17, 2012Publication date: August 14, 2014Applicants: KONRAD-ZUSE-INSTITUT, CHARITÉ UNIVERSITÃTSMEDIZIN BERLINInventors: Christoph Stein, Marcus Weber, Christian Zöllner, Olga Scharkoi
-
Publication number: 20120328619Abstract: The present invention relates to a molecule having binding specificities for (a) CD123; (b) CD16 and (c) CD33. The present invention further relates to the molecule of the invention, wherein the molecule comprises a first immunoglobulin domain comprising a VL domain linked to a VH domain, wherein the immunoglobulin domain specifically binds to CD123; a second immunoglobulin domain comprising a VL domain linked to a VH domain, wherein the immunoglobulin domain specifically binds to CD16; and a third immunoglobulin domain comprising a VL domain linked to a VH domain, wherein the immunoglobulin domain specifically binds to CD33. The present invention furthermore relates to a nucleic acid molecule encoding the molecule of the invention. In addition, the present invention relates to diagnostic and pharmaceutical compositions and the use of the molecule or the nucleic acid molecule of the invention in the treatment of acute myeloid leukaemia and/or myelodysplastic syndrome.Type: ApplicationFiled: December 9, 2010Publication date: December 27, 2012Inventors: Georg H. Fey, Christoph Stein, Christian Kellner, Markus Kügler
-
Patent number: 6787149Abstract: The invention is directed to methods and pharmaceutical compositions for the topical administration of opioid analgesic drugs such as morphine. In particular, the invention relates to topical administration of an opioid analgesic agent, e.g., morphine sulfate, to produce a localized analgesic effect in inflamed skin or mucosal tissue, and without a transdermal or transmucosal migration of opioid agent, e.g., into the systemic circulation.Type: GrantFiled: January 10, 2000Date of Patent: September 7, 2004Assignee: El Khoury and Stein Ltd.Inventors: George F. El Khoury, Christoph Stein
-
Publication number: 20040138115Abstract: A remedy to suppress the sensation of pain, especially in chronic inflammatory diseases, by means of expressing endogenous neuroendocrine peptides at the site of inflammation. In particular, the invention relates to the expression of POMC or CRF from locally injected DNA expression constructs, preferably covalently peptide-modified expression constructs.Type: ApplicationFiled: August 22, 2003Publication date: July 15, 2004Inventors: Burghardt Wittig, Christoph Stein, Michael Schafer, Matthias Schroff, Claas Junghans, Sven Andres Konig Merediz
-
Patent number: 5948389Abstract: The present invention is a method for enhancing the analgesic efficacy of a locally applied opioid analgesic or local anesthetic agent in a mammal having an impermeable perineurium barrier sheet about the peripheral sensory nerves at the site of action of the analgesic or anesthetic agent. The method involves applying to that site an effective amount of the analgesic or anesthetic agent dissolved in a hyperosmolar solution having an osmolality of above 300 mOsm/l.Type: GrantFiled: September 3, 1997Date of Patent: September 7, 1999Assignee: El Khoury & Stein, Ltd.Inventor: Christoph Stein
-
Patent number: 5589480Abstract: The present invention is directed to a method and apparatus for the topical application of opioid analgesic drugs such as morphine. Specifically, the present invention relates to a topical application of the opioid drug and specifically a morphine sulphate in a diluted solution to produce an analgesic effect in a localized area and typically in a localized inflamed area and without a transdermal migration of the opioid drug into the blood stream.Type: GrantFiled: August 17, 1994Date of Patent: December 31, 1996Inventors: George F. Elkhoury, Christoph Stein