Abstract: The present invention relates to the field of oncology. laboratory tools and methods, and especially anti-tumor DNA crosslinking agents. Most patients with advanced solid tumors develop resistance to chemotherapy due to the ability of cancer cells to repair or tolerate sustained DNA damages. The inventors showed that the compounds according to the present invention allow the detection and visualization of alkylated DNA damages induced by PBDs without altering their DNA crosslinking ability. This enables the study of the effect and properties of PBDs. In particular, the present invention relates new derivates of PBD molecules and their synthesis. The present invention also relates to a method for visualizing DNA crosslinking: to a method for assessing the resistance of a tumor to a crosslinking agent and to a method for identifying a molecule or treatment for improving the efficiency of a crosslinking agent.

Abstract: A protective barrier well suited for use in sublimation printing is made primarily from cellulose fibers. The protective barrier, which can comprise an uncoated paper, can be used to prevent sublimation inks from bleeding through a fabric onto the printing equipment. The uncoated paper is recyclable and can enter the paper recycle stream. The uncoated paper can contain first cellulose fibers combined and blended with second cellulose fibers that differ in fiber length and/or in the degree of refining. The uncoated paper is constructed to have a relatively low diffusivity.

Abstract: A syringe including an injection syringe body and a syringe handle, configured to cooperate with one another in order to ensure a locking function between the injection syringe body and the syringe handle. The injection syringe body includes a longitudinal hub including at least one female or male retaining element, and a protective sheath moveable along said longitudinal hub and able to cover in a retracted position the at least one retaining element of the longitudinal hub. The syringe handle includes at least one male or female retaining element intended to cooperate with the at least one female or male retaining element of the longitudinal hub, ensuring a retaining function, the cooperation being named locking position. The syringe further includes at least one blocker, the at least one blocker ensuring a radial holding function when the retracted and the locking positions are both engaged.

Abstract: A syringe including an injection syringe body and a syringe handle, configured to cooperate with one another in order to ensure a locking function between the injection syringe body and the syringe handle. The injection syringe body includes a longitudinal hub including at least one female or male retaining element, and a protective sheath moveable along said longitudinal hub and able to cover in a retracted position the at least one retaining element of the longitudinal hub. The syringe handle includes at least one male or female retaining element intended to cooperate with the at least one female or male retaining element of the longitudinal hub, ensuring a retaining function, the cooperation being named locking position. The syringe further includes at least one blocker, the at least one blocker ensuring a radial holding function when the retracted and the locking positions are both engaged.

Abstract: A protective sheath (100) for a cannula (210) arranged on a hub (200) which can be fitted onto a syringe (300), the sheath including female elements intended to cooperate with male elements (201) of the hub (200) for guiding thereof, and characterized in that the female elements include a retracted position before use RBU, a retracted position during use RU, and a retracted position after use RAU, wherein the whole length of the cannula (210) is inside the sheath (100), the female elements further include an ejection position E, wherein whole or part of the cannula (210) protrudes out of the sheath (100), and further characterized in that at least two of the RBU, RU, and RAU positions are substantially transversally aligned.

Abstract: A protective sheath (100) for a cannula (210) arranged on a hub (200) which can be fitted onto a syringe (300), the sheath including female elements intended to cooperate with male elements (201) of the hub (200) for guiding thereof, and characterized in that the female elements include a retracted position before use RBU, a retracted position during use RU, and a retracted position after use RAU, wherein the whole length of the cannula (210) is inside the sheath (100), the female elements further include an ejection position E, wherein whole or part of the cannula (210) protrudes out of the sheath (100), and further characterized in that at least two of the RBU, RU, and RAU positions are substantially transversally aligned.

Abstract: This invention relates to a method for mixing a first injectable liquid pharmaceutical composition and a second injectable composition within an injection device, said injection device including: ·a generally cylindrical shell in which a cartridge is lodged or a generally cylindrical barrel, ·at one first end of the generally cylindrical barrel or the generally cylindrical shell, a plunger, the plunger being mounted on the barrel or shell, ·at a second end opposite the first end of the generally cylindrical barrel or the generally cylindrical shell, is provided a needle assembly support member, on which may be mounted a needle assembly, said needle assembly comprising means to be mounted on the needle support member, and further comprising: -at least one hollow cannula for transportation of liquid from the barrel or cartridge to the body of the patient; -and at least one hub surrounding part of the cannula and attached to cannula; said hub possibly including a hollow part; characterized in that the first inje