Abstract: Provided are compositions comprising compounds or precursors to compounds which may be used for a variety of therapeutic applications including, for example, treating and/or preventing a disease or disorder related to reduced or inadequate mitochondrial activity, including aging or stress, diabetes, obesity, and neurodegenerative diseases. The compounds relate generally to urolithins and precursors thereof, including but not limited to ellagitannins and urolithin A. In certain embodiments the compositions are presented in or as food products or nutritional supplements. These same compounds and compositions can also be used advantageously in generally healthy individuals to increase or maintain metabolic rate, decrease percent body fat, increase or maintain muscle mass, manage body weight, improve or maintain mental performance (including memory), improve or maintain muscle performance, improve or maintain mood, and manage stress.

Abstract: A method for image-based orthodontic treatment may include receiving image data of a patient's dentition and an orthodontic appliance, identifying, from the image data, the orthodontic appliance, calculating a misalignment height of a misalignment of the orthodontic appliance with respect to the patient's dentition, determining whether the misalignment height satisfies a misalignment threshold, and in response to satisfying the misalignment threshold, providing a notification.

Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand with open ends around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The preferred embodiment of the catheter includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.

Abstract: A navigation apparatus for use in navigating a pipe having a sidewall defining an interior cavity is provided. The navigation apparatus includes a body assembly having a first end and a second end and configured to move through the interior cavity of the pipe. The navigation apparatus also includes a channel defining a fluid passageway extending at least partly between the first end and the second end of the body assembly, an inlet for fluid from the interior cavity of the pipe to enter the fluid passageway, and an outlet for the fluid to exit the fluid passageway and return to the interior cavity of the pipe. The channel is configured to allow the fluid to flow through the fluid passageway and from the first end of the body assembly to the second end of the body assembly as the body assembly moves through the interior cavity of the pipe.

Abstract: A helmet is provided that can include a cage defining a front end, a back end opposite the front end, a first lateral end and a second lateral end opposite the first lateral end. The cage can include multiple longitudinal beams that extend between the back end of the cage and the front end of the cage; and a transverse beam that extends between the first lateral end of the cage and the second lateral end of the cage. The transverse beam can be anchored to the multiple longitudinal beams. The helmet can include a body that fully encapsulates the multiple longitudinal beams of the cage and that partially encapsulates the transverse beam. The body can define multiple vents. Each vent can be situated between two adjacent longitudinal beams. The transverse beam can extend through one of the multiple vents.

Abstract: A tunneling device includes a body assembly, an expander coupled to the body assembly and extending along a longitudinal axis, and a tip coupled to the expander. The expander is disposed between a force transmitter and the tip. The expander is expandable in a direction perpendicular to the longitudinal axis between a first configuration having a first width measured perpendicular to the longitudinal axis and a second configuration having a second width measured perpendicular to the longitudinal axis. The tip has a width measured perpendicular to the longitudinal axis. The first width of the expander is equal to or less than the width of the tip. The force transmitter is configured to deliver a force through the expander to the tip to move the tip in a direction parallel to the longitudinal axis with the expander in the second configuration.

Abstract: In some embodiments, a wearable device detects a trigger event. The trigger event indicates a type of measurement to take. Based on the trigger event, the wearable device selects an instruction audio message corresponding to the type of measurement to be taken. The instruction audio message includes instructions for how to conduct the type of measurement. The wearable device connects to an appropriate measuring apparatus based on the type of measurement to be taken and the instruction audio message. The wearable device plays the instruction audio message to a patient of the wearable device. The wearable device receives measurements from the appropriate measuring apparatus.

Abstract: A method of selectively recovering a lipophilic target substance. An insoluble adsorbent is exposed to a solution of the target substance in a lipophilic solvent. Adsorption of the adsorbent with the target substance is facilitated by addition of hydrophilic solvent, which is less hydrophobic than the lipophilic solvent, to the solution during or after exposure of the solution to the insoluble adsorbent, lowering the temperature of the solution or evaporating a portion of the lipophilic solvent. The adsorbent Is isolated from the solution. For desorbing and recovering the target substance, a hydrophobic dissociation fluid may be combined with the adsorbent, a temperature of the adsorbent may be increased or a portion of the hydrophilic solvent may be evaporated. A solution may be exposed to one or more adsorbents for recovering additional lipophilic target substances, recovering hydrophilic target substances or removing unwanted substances.

Abstract: In one embodiment, a catheter apparatus is configured to be inserted into a body part of a living subject, and including an elongated deflectable element including a distal end, an expandable basket assembly disposed at the distal end and comprising a plurality of splines and a plurality of electrodes disposed on the splines, an irrigation channel disposed in the elongated deflectable element, and an inflatable balloon disposed in the expandable basket assembly and including a plurality of irrigation holes in fluid connection with the irrigation channel.

Abstract: Compositions are provided for dissolvable solid unit dose formulations that can be used with a wand apparatus to clean a toilet surface. The formulations include anionic surfactant, a carbonate or bicarbonate salt, an organic acid, and virgin soap pellets wherein a ratio of the virgin soap pellets to the surfactant is from about 0.5:1 to about 2:1, preferably about 1:1 to about 1.5:1, and most preferably about 1.2:1 to 1.3:1. Compressed compositions retain sufficient hardness to facilitate cleaning a toilet surface but are still able to have a time to breakage when submerged in toilet water of less than 5 minutes to enable easy disposal by flushing with toilet water.

Abstract: An orthopedic spacer assembly can include a bone plate and a spacer. The bone plate can include a first end portion and a second end portion, the second end portion defining a plurality of anchor openings. The spacer can have a c-shaped body and can include a central bore extending through a thickness of the spacer. The spacer can be disposed between the bone plate and a subject's bone such that the central bore of the spacer aligns with an anchor opening of the plurality of anchor openings.

Abstract: A portable cooler container is provided. The temperature control system cools a chamber of the container to transport temperature sensitive contents via the container. An electronic display screen on one of the lid and the container body selectively displays an electronic shipping label for the portable cooler container.

Abstract: An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.

Abstract: Described are a system, method, and computer program product for secure client device and consumer authentication. The method includes receiving a primary account number (PAN) of an account of a consumer from a merchant system and determining whether the PAN has been registered with a public key of a public-private key pair of a client device of the consumer. The method also includes, in response to determining that the PAN has been registered, transmitting a login request to a transaction processing system including a device identifier of the client device based on the PAN. The method further includes receiving a login response from the transaction processing system associated with successful authentication of the client device and, in response to receiving the login response, processing a transaction by generating a transaction authorization request message including the PAN to the transaction processing system.

Abstract: Materials and methods for producing tactile anatomical structures are described. These are intended primarily for use for high-value, in-depth surgical training for novice or expert surgeons. They may also be used for medical education, sales demonstrations, or for research and development. Examples of embodiments refer to their use in knee and shoulder models. The tactile tissue-simulating structures include, amongst others: skin, fat, muscles, ligaments, tendons, cartilage, bursa, fat pad, and periosteum. A method for creating a musculotendinous junction is also described.

Abstract: A strengthened cover glass or glass-ceramic sheet or article as well as processes and systems for making the strengthened glass or glass-ceramic sheet or article is provided for use in consumer electronic devices. The process comprises cooling the cover glass sheet by non-contact thermal conduction for sufficiently long to fix a surface compression and central tension of the sheet. The process results in thermally strengthened cover glass sheets for use in or on consumer electronic products.

Abstract: Methods, devices and systems are disclosed for inter-app communications between software applications on a mobile communications device. In one aspect, a computer-readable medium on a mobile computing device comprising an inter-application communication data structure to facilitate transitioning and distributing data between software applications in a shared app group for an operating system of the mobile computing device includes a scheme field of the data structure providing a scheme id associated with a target software app to transition to from a source software app, wherein the scheme id is listed on a scheme list stored with the source software app; and a payload field of the data structure providing data and/or an identification where to access data in a shared file system accessible to the software applications in the shared app group, wherein the payload field is encrypted.

Abstract: The present invention is related to the prevention of intrusions on an in-vehicle network.

Abstract: A cuffed tracheal tube has a shaft (10) with an inner component (30) having an inflation lumen (23) extending along a rib (33) along the outside of the component. The rib (33) terminates a short distance rearwardly of the patient end (14) of the inner component. The inflation lumen (23) is closed by an outer layer (51) applied over the inner component (30) and covering the patient end of the rib. Two closely spaced openings (54) through the rib (33) are spaced in the inflatable region of a silicone sealing cuff (13) secured around the patient end of the shaft.