Patents by Inventor Christopher A. Tsu

Christopher A. Tsu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acids encoding a collagenase
    Patent number: 6017747
    Abstract: An isolated sequence is provided that encodes crab serine collagenase I. The mature recombinant collagenase (SEQ. I.D. No:4) has a molecular weight of 23,500 and may be expressed in a variety of expression systems for production of readily isolated and reliably pure collagenase with excellent specificity. The recombinant collagenase, however, may be expressed in inactive, zymogen form so as to provide long-term, shelf-stable protease that can be readily activated when collagenolytic activity is desired.
    Type: Grant
    Filed: December 3, 1997
    Date of Patent: January 25, 2000
    Assignee: The Regents of the University of California
    Inventors: Charles S. Craik, Christopher A. Tsu
  • Recombinant crab collagenase
    Patent number: 5747322
    Abstract: An isolated sequence is provided that encodes crab procollagenase (Seq ID NO 5) that upon cleaving off the 29 amino acid propeptide (Seq ID NO 6) transforms into an active collagenase (Seq ID NO 4). The procollagenase has the MW of about 26.6 kD and the mature collagenase has a MW of 23.5 kD. Procollagenase mutated at positions 201 and 235 is also provided. A storage-stabilized composition providing long-term, shelf-stable protease that can be readily activated when collagenolytic activity is desired is disclosed.
    Type: Grant
    Filed: May 9, 1996
    Date of Patent: May 5, 1998
    Assignee: The Regents of the University of California
    Inventors: Charles S. Craik, Christopher A. Tsu