Abstract: Disclosed herein are systems for aspirating, irrigating, and/or mechanically disrupting body cavities, such as abdominal abscesses, empyemas, and/or (e.g., complicated) pleural effusions, and associated devices and methods. In some embodiments, an aspiration and irrigation system includes an inner catheter defining an aspiration lumen and an outer tube positioned coaxially around the inner catheter and defining an irrigation lumen. A distal portion of the outer tube can be bonded to the inner catheter, and a plurality of apertures can be formed through the outer tube proximal of the bond. The aspiration lumen can be fluidly coupled to an aspiration circuit configured to aspirate through the aspiration lumen, and the irrigation lumen can be fluidly coupled to an irrigation circuit configured to flow an irrigation fluid through the irrigation lumen and out of the apertures.

Abstract: Disclosed herein are clot treatment systems with filtering syringes, and associated devices and methods. The filtering syringe can be coupled to a catheter subsystem insertable within a patient. The filtering syringe can aspirate material (e.g., clot material, blood, etc.) from a patient via the catheter subsystem. The filtering syringe can include a plunger assembly, and the plunger assembly can include one or more filters. Each of the filters can be configured to (i) allow at least a first portion of aspirated material (e.g., blood) to pass through at least one of the filters, and (ii) prevent at least a second portion of the aspirated material (e.g., clot material) from passing through at least one of the filters. In some embodiments, the filtering syringe is fluidly coupled to a filtered material subsystem that can fluidly couple the filtering syringe to the patient or another suitable fluid outflow location.

Abstract: Automatically-locking syringes are disclosed herein. A syringe in accordance with embodiments of the present technology can include (i) a barrel, (ii) a plunger slidably positioned within the barrel, and (iii) a lock plate coupled to the barrel. The plunger also extends through an opening in the lock plate, and a biasing member is configured to bias the lock plate to a locking position. When the plunger is moved from a depressed position to a withdrawn position, the lock feature engages the lock plate to drive the lock plate away from the locking position to thereby permit the lock feature to pass through the opening in the lock plate. After the lock feature passes through the opening, the biasing member drives the lock plate to the locking position to inhibit movement of the plunger from the withdrawn position to the depressed position.

Abstract: Systems and methods for the intravascular treatment of clot material within a blood vessel of a human patient are disclosed herein. In one embodiment, a funnel catheter assembly includes an outer shaft and an inner shaft extending through and coaxial with the outer shaft. An expandable funnel can be coupled to a distal portion of the inner shaft. The funnel catheter assembly further includes a control assembly operably coupled to the proximal portion of the outer shaft and configured to move the outer shaft between a first position and a second position. In the first position, the outer shaft is positioned at least partially over the funnel to constrain the funnel in a compressed state. In the second position, the outer shaft is retracted proximally relative to the funnel such that the funnel can expand to an expanded state.