Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.

Abstract: Systems and methods for maintaining an electronic health records system, including a server storing a medical records database. Requests for medical data for a patient in a master problem list are received from a user device, and appropriate list permissions are determined and granted for hierarchical derivative problem lists. Annotated data is received at the server from a user device based on annotations made to a derivative problem list, and problem lists are updated with the received annotated data in real time. The received annotated data is compared with current entries using natural language processing to detect duplicate entries, the duplicate entries are iteratively detected and removed from the master problem list, and non-duplicate entries are stored in authorized derivative problem lists based on the natural language processing and list update permissions for each of the derivative problem lists.

Abstract: Systems and methods provide logic for decentralized request routing. In one implementation, a computer-implemented method routes a request. The method includes receiving, by a client server, the request. The client server evaluates feedback information received by the client server from at least one of a plurality of host servers. The client server selects one of the plurality of host servers to process the request, based on the evaluation, and transmits the request to the selected one of the plurality of host servers.

Abstract: Systems and methods provide logic for decentralized request routing. In one implementation, a computer-implemented method routes a request. The method includes receiving, by a client server, the request. The client server evaluates feedback information received by the client server from at least one of a plurality of host servers. The client server selects one of the plurality of host servers to process the request, based on the evaluation, and transmits the request to the selected one of the plurality of host servers.

Abstract: Systems and methods provide logic for decentralized request routing. In one implementation, a computer-implemented method routes a request. The method includes receiving, by a client server, the request. The client server evaluates feedback information received by the client server from at least one of a plurality of host servers. The client server selects one of the plurality of host servers to process the request, based on the evaluation, and transmits the request to the selected one of the plurality of host servers.

Abstract: Systems and methods provide automated provisioning of load balancing. In one implementation, a computer-implemented method configures an access point. A request to create the access point may be received and data for the access point may be stored in a data store. The method may invoke a workflow engine. The workflow engine may assign the access point to a load balancer, configure the load balancer, assign a network address to the load balancer, and publish the network address for a plurality of clients.