Patents by Inventor Christopher D. Batich
Christopher D. Batich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20080045825Abstract: The present invention provides systems and methods for analyzing glucose present in exhaled breath condensate (EBC). In certain embodiments of the invention, electrochemical- or coulometric-based sensing technologies are used to analyze EBC for the presence and/or concentration of glucose.Type: ApplicationFiled: August 15, 2006Publication date: February 21, 2008Inventors: Richard J. Melker, David G. Bjoraker, Donn M. Dennis, Jon D. Stewart, Christopher D. Batich, Matthew M. Booth, John Frederick Horn, Ronald E. Youngblood
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Patent number: 7122030Abstract: A method of localized cell heating introduces a plurality of ferroelectric comprising particles into a target region of a patient, and applies a time varying electrical field to the target region. The ferroelectric particles absorb energy from the electrical field and heat the target region in response, such as to a temperature sufficient to induce apoptosis of cancer cells in the target region. A ferroelectric hyperthermia-based cancer treatment system includes a time varying electrical field source for applying a time varying electrical field to a plurality of ferroelectric particles disposed in a target cancer containing region of a patient. A composition of matter includes a particle having a ferroelectric portion, the particle being non-toxic, slowly biodegradable in body fluids, and less than 15 ?m in its maximum dimension.Type: GrantFiled: July 13, 2004Date of Patent: October 17, 2006Assignee: University of Florida Research Foundation, Inc.Inventors: Glen Patrick Flores, Christopher D. Batich
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Patent number: 7045673Abstract: Absorbent dressings, including highly-absorbent dressings having antimicrobial polymer attached thereto via non-siloxane bonds are disclosed. Bandages (i.e. wound dressing), sanitary napkins and the like are useful applications for the intrinsically bactericidal absorbent dressings whose method of manufacture and use are disclosed and claimed.Type: GrantFiled: December 8, 1999Date of Patent: May 16, 2006Assignees: Quick-Med Technologies, Inc., University of Florida Research Foundation, Inc.Inventors: Christopher D. Batich, Bruce A Mast, Gregory Schultz, Gerald M. Olderman, David S. Lerner
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Patent number: 7001616Abstract: The subject invention pertains to novel materials and methods for use in treating patients afflicted with oncological disorders, such as tumors. One aspect of the invention concerns methods for treating tumors comprising the administration of drug loaded pH-sensitive microspheres to a patient in need of anticancer therapy. The pH-sensitive microspheres have a swelling transition with the pH range found in or near tumor tissue. When the microspheres swell, the loaded drug is released into the microenvironment of the tumor tissue. The subject invention also pertains to novel microspheres useful in the methods of the invention. The microspheres are capable of effectively releasing a loaded substance at a predetermined pH. The subject invention also concerns novel methods for synthesizing the microspheres of the present invention.Type: GrantFiled: May 8, 2003Date of Patent: February 21, 2006Assignee: University of FloridaInventors: Christopher D. Batich, Adam Leckey, J. Nicolas Vauthey
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Patent number: 6812314Abstract: The subject invention pertains to branched polyolefin materials that exhibit temperature-sensitive permeability. The subject invention also concerns a package including a polymer material that exhibits temperature-sensitive permeability and separates a respiring article from the surrounding atmosphere. Methods of the subject invention involve placing a respiring article within a container comprising a polymer material exhibiting temperature-sensitive permeability.Type: GrantFiled: October 17, 2001Date of Patent: November 2, 2004Assignee: University of FloridaInventors: Gilberto Joao Lunardi, Christopher D. Batich, Jorge Jardim Zacca, Kenneth Ray Berger, Steven Sargent
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Publication number: 20030236457Abstract: Disclosed are the following strategies for endovascularly mapping the brain with a chemical agent capable of staining the preselected region of the brain to a color visibly contrasting with non-stained portions of the brain and of passing through the blood-brain barrier to the preselected region of the brain: 1) Passive transport: (a) pro-drug, (b) Modification of mapping agent to mimic molecules that readily cross the BBB (e.g., amino acid, glucose, etc.); 2) Active transport; 3) Receptor-mediated transport (e.g., antibody mediated); 4) Blood brain barrier (BBB) manipulation; 5) Emulsification of agent (such as carotene, organic dye, etc.) to stain capillary endothelium; 6) Embolization of brain capillaries; 7) Grafted-nanoparticle systems for brain delivery of mapping agent.Type: ApplicationFiled: April 24, 2003Publication date: December 25, 2003Inventors: Robert A. Mericle, Christopher D. Batich, Courtney S. Watkins, Matthew V. Burry, O. Erich Richter, Swadeshmukul Santra
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Publication number: 20030202936Abstract: The subject invention pertains to novel materials and methods for use in treating patients afflicted with oncological disorders, such as tumors. One aspect of the invention concerns methods for treating tumors comprising the administration of drug loaded pH-sensitive microspheres to a patient in need of anticancer therapy. The pH-sensitive microspheres have a swelling transition with the pH range found in or near tumor tissue. When the microspheres swell, the loaded drug is released into the microenvironment of the tumor tissue. The subject invention also pertains to novel microspheres useful in the methods of the invention. The microspheres are capable of effectively releasing a loaded substance at a predetermined pH. The subject invention also concerns novel methods for synthesizing the microspheres of the present invention.Type: ApplicationFiled: May 8, 2003Publication date: October 30, 2003Inventors: Christopher D. Batich, Adam Leckey, J. Nicolas Vauthey
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Patent number: 6602524Abstract: The subject invention pertains to novel materials and methods for use in treating patients afflicted with oncological disorders, such as tumors. One aspect of the invention concerns methods for treating tumors comprising the administration of drug loaded pH-sensitive microspheres to a patient in need of anticancer therapy. The pH-sensitive microspheres have a swelling transition with the pH range found in or near tumor tissue. When the microspheres swell, the loaded drug is released into the microenvironment of the tumor tissue. The subject invention also pertains to novel microspheres useful in the methods of the invention. The microspheres are capable of effectively releasing a loaded substance at a pre-determined pH. The subject invention also concerns novel methods for synthesizing the microspheres of the present invention.Type: GrantFiled: August 10, 2001Date of Patent: August 5, 2003Assignee: University of FloridaInventors: Christopher D. Batich, Adam Leckey, J. Nicolas Vauthey
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Publication number: 20030072849Abstract: The subject invention pertains to branched polyolefin materials that exhibit temperature-sensitive permeability. The subject invention also concerns a package including a polymer material that exhibits temperature-sensitive permeability and separates a respiring article from the surrounding atmosphere. Methods of the subject invention involve placing a respiring article within a container comprising a polymer material exhibiting temperature-sensitive permeability.Type: ApplicationFiled: October 17, 2001Publication date: April 17, 2003Inventors: Gilberto Joao Lunardi, Christopher D. Batich, Jorge Jardim Zacca, Kenneth Ray Berger, Steven Sargent
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Publication number: 20020177828Abstract: This invention relates to methods and compositions for materials having a non-leaching coating that has antimicrobial properties. The coating is applied to substrates such as gauze-type wound dressings. Covalent, non-leaching, non-hydrolyzable bonds are formed between the substrate and the polymer molecules that form the coating. A high concentration of anti-microbial groups on multi-length polymer chains and relatively long average chain lengths, contribute to an absorbent or superabsorbent surface with a high level antimicrobial effect.Type: ApplicationFiled: September 28, 2001Publication date: November 28, 2002Inventors: Christopher D. Batich, Gregory Schultz, Bruce A. Mast, Gerald M. Olderman, David S. Lerner, William Toreki
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Publication number: 20020009415Abstract: The subject invention pertains to novel materials and methods for use in treating patients afflicted with oncological disorders, such as tumors. One aspect of the invention concerns methods for treating tumors comprising the administration of drug loaded pH-sensitive microspheres to a patient in need of anticancer therapy. The pH-sensitive microspheres have a swelling transition with the pH range found in or near tumor tissue. When the microspheres swell, the loaded drug is released into the microenvironment of the tumor tissue. The subject invention also pertains to novel microspheres useful in the methods of the invention. The microspheres are capable of effectively releasing a loaded substance at a pre-determined pH. The subject invention also concerns novel methods for synthesizing the microspheres of the present invention.Type: ApplicationFiled: August 10, 2001Publication date: January 24, 2002Inventors: Christopher D. Batich, Adam Leckey, J. Nicolas Vauthey
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Patent number: 6306422Abstract: A method for the controlled release of a biologically active agent wherein the agent is released from a hydrophobic, pH-sensitive polymer matrix is disclosed and claimed. In one embodiment, the polymer matrix swells when the environment reaches pH 8.5, releasing the active agent. A polymer of hydrophobic and weakly acidic comonomers is disclosed for use in the controlled release system. In another embodiment, weakly basic comonomers are used and the active agent is released as the pH drops. Further disclosed is a specific embodiment in which the controlled release system may be used. The pH-sensitive polymer is coated onto a latex catheter used in ureteral catheterization. A common problem with catheterized patients is the infection of the urinary tract with urease-producing bacteria. In addition to the irritation caused by the presence of the bacteria, urease produced by these bacteria degrade urea in the urine, forming carbon dioxide and ammonia. The ammonia causes an increase in the pH of the urine.Type: GrantFiled: August 3, 1998Date of Patent: October 23, 2001Assignee: CApHCO, Inc.Inventors: Christopher D. Batich, Marc S. Cohen, Kirk Foster, William Toreki, III
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Patent number: 6274159Abstract: An improved implantable pharmaceutical depot for the prolonged release of at least one biologically active substance, the depot comprising a polymeric carrier and the biologically active substance, the improvement wherein the depot is coated or surface modified with a biologically active and biocompatible glass, glass-ceramic or ceramic material, the coating or modified surface being capable of forming a bond to soft tissue upon implantation. Methods for forming the biologically active and biocompatible glass, glass-ceramic or ceramic coating or modified surface on the silicone based depot are also disclosed.Type: GrantFiled: October 28, 1999Date of Patent: August 14, 2001Assignee: University of FloridaInventors: James S. Marotta, Christopher D. Batich, Nancy S. Hardt
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Patent number: 6139821Abstract: This invention relates to novel compositions containing temporary visual indicators and methods for using these compositions. Specifically, this invention relates to a sunscreen composition containing an indicator that is visible when the substance is applied to the skin, but becomes invisible shortly after application. The continued presence of the indicator allows the indicator to be reactivated temporarily to the visible form so that a user can verify the presence of the sunscreen. The visible indicator ensures that the sunscreen is applied evenly and completely to the area to be protected, but becomes invisible so as not to interfere with the action of the sunscreen or discolor the skin.Type: GrantFiled: July 27, 1999Date of Patent: October 31, 2000Assignee: IPA, LLCInventors: Ronnie S. Fuerst, Christopher D. Batich, Richard J. Melker
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Patent number: 5997891Abstract: This invention relates to novel compositions containing temporary visual indicators and methods for using these compositions. Specifically, this invention relates to a sunscreen composition containing an indicator that is visible when the substance is applied to the skin, but becomes invisible shortly after application. The continued presence of the indicator allows the indicator to be reactivated temporarily to the visible form so that a user can verify the presence of the sunscreen. The visible indicator ensures that the sunscreen is applied evenly and completely to the area to be protected, but becomes invisible so as not to interfere with the action of the sunscreen or discolor the skin.Type: GrantFiled: August 18, 1998Date of Patent: December 7, 1999Assignee: IPA, LLCInventors: Ronnie S. Fuerst, Richard Melker, Christopher D. Batich
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Patent number: 5851942Abstract: A method of preparing polymer derived silicon fibers comprising the steps of providing a spin dope solution comprising a silicon carbide forming organosilicon polymer, preferably polycarbosilane, a solvent, a soluble boron precursor, preferably solid boron hydride, and a nitrogen containing precursor, preferably polyvinylsilazane; spinning the solution to form high strength green fibers; and heat treating the green fibers to produce high strength, homogeneously doped, boron containing fibers. The fibers produced are high strength, homogeneously boron doped silicon carbide fibers with average tensile strength in the range of from about 2.0 to 4.0 GPa at room temperature.Type: GrantFiled: August 20, 1997Date of Patent: December 22, 1998Assignee: University of FloridaInventors: Michael D. Sacks, William Toreki, Christopher D. Batich, Guang J. Choi
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Patent number: 5837645Abstract: This invention relates to novel compositions containing temporary visual indicators and methods for using these compositions. Specifically, this invention relates to a sunscreen composition containing an indicator that is visible when the substance is applied to the skin, but becomes invisible shortly after application. The continued presence of the indicator allows the indicator to be reactivated temporarily to the visible form so that a user can verify the presence of the sunscreen. The visible indicator ensures that the sunscreen is applied evenly and completely to the area to be protected, but becomes invisible so as not to interfere with the action of the sunscreen or discolor the skin.Type: GrantFiled: July 1, 1996Date of Patent: November 17, 1998Inventors: Ronnie S. Fuerst, Richard Melker, Christopher D. Batich
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Patent number: 5792416Abstract: A method of preparing polymer derived silicon fibers comprising the steps of providing a spin dope solution comprising a silicon carbide forming organosilicon polymer, preferably polycarbosilane, a solvent, a soluble boron precursor, preferably solid boron hydride, and a nitrogen containing precursor, preferably polyvinylsilazane; spinning the solution to form high strength green fibers; and heat treating the green fibers to produce high strength, homogeneously doped, boron containing fibers. The fibers produced are high strength, homogeneously boron doped silicon carbide fibers with average tensile strength in the range of from about 2.0 to 4.0 GPa at room temperature.Type: GrantFiled: July 18, 1996Date of Patent: August 11, 1998Assignee: University of FloridaInventors: Michael D. Sacks, William Toreki, Christopher D. Batich, Guang J. Choi
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Patent number: 5788687Abstract: A method for the controlled release of a biologically active agent wherein the agent is released from a hydrophobic, pH-sensitive polymer matrix is disclosed and claimed. In one embodiment, the polymer matrix swells when the environment reaches pH 8.5, releasing the active agent. A polymer of hydrophobic and weakly acidic comonomers is disclosed for use in the controlled release system. In another embodiment, weakly basic comonomers are used and the active agent is released as the pH drops. Further disclosed is a specific embodiment in which the controlled release system may be used. The pH-sensitive polymer is coated onto a latex catheter used in ureteral catheterization. A common problem with catheterized patients is the infection of the urinary tract with urease-producing bacteria. In addition to the irritation caused by the presence of the bacteria, urease produced by these bacteria degrade urea in the urine, forming carbon dioxide and ammonia. The ammonia causes an increase in the pH of the urine.Type: GrantFiled: July 31, 1995Date of Patent: August 4, 1998Assignee: CApHCO, IncInventors: Christopher D. Batich, Marc S. Cohen, Kirk Foster, William Toreki, III
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Patent number: 5776701Abstract: The subject invention pertains to a novel assay device for detecting oxalate in a sample. The assay device comprises enzyme and dye compositions immobilized on a solid carrier matrix. The subject invention can also be used to measure the concentration of oxalate in a sample. The subject invention further pertains to a novel oxalate oxidase composition and methods of preparing the subject enzyme composition. The oxalate oxidase composition can be used in the assay device of the subject invention.Type: GrantFiled: May 31, 1996Date of Patent: July 7, 1998Assignee: University of FloridaInventors: Rusty Jay Mans, Christopher D. Batich, Ian McFetridge