Patents by Inventor Christopher D. Howe
Christopher D. Howe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230338974Abstract: A powder spray applicator system may include an applicator device configured to eject particles of powder in a stream of a heated gas. The applicator device defining a particle path along which particles of the powder stream move upon introduction into a flow chamber and a gas path along which a primary gas stream moves upon introduction into the flow chamber. The applicator device may include a body assembly defining an outer annular gap forming a first section of the gas path and an inner annular gap forming a second section of the gas path, and a spray nozzle defining a flow passage extending between an entry opening of the spray nozzle and an exit opening of the spray nozzle. The flow passage may have an initial section with a converging shape and a final section with a straight shape.Type: ApplicationFiled: March 28, 2023Publication date: October 26, 2023Inventors: HELMUT P. HOELL, AARON T. NARDI, CHRISTOPHER D. HOWE
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Patent number: 9926287Abstract: A method of crystallizing docetaxel is disclosed. The method comprises (a) combining docetaxel and at least one solubilizing solvent to obtain a solution, wherein the solubilizing solvent is selected from the group consisting of acetone, methyl-tert-butyl ether, tetrahydrofuran (THF), and acetonitrile and (b) adding an anti-solvent to the solution to obtain a crystalline docetaxel, wherein the anti-solvent is water.Type: GrantFiled: November 18, 2016Date of Patent: March 27, 2018Assignee: Phyton Holdings, LLCInventors: Brian A. Bucher, Edward M. Desimone, III, Roland R. Franke, Rex T. Gallagher, Barry J. Hand, Christopher D. Howe, James H. Johnson, John S. Juchum, Marc A. Plante, T.G. Sambandam, Dong S. Yang
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Publication number: 20170066734Abstract: A method of crystallizing docetaxel is disclosed. The method comprises (a) combining docetaxel and at least one solubilizing solvent to obtain a solution, wherein the solubilizing solvent is selected from the group consisting of acetone, methyl-tert-butyl ether, tetrahydrofuran (THF), and acetonitrile and (b) adding an anti-solvent to the solution to obtain a crystalline docetaxel, wherein the anti-solvent is water.Type: ApplicationFiled: November 18, 2016Publication date: March 9, 2017Inventors: Brian A. Bucher, Edward M. Desimone, III, Roland R. Franke, Rex T. Gallagher, Barry J. Hand, Christopher D. Howe, James H. Johnson, John S. Juchum, Marc A. Plante, T.G. Sambandam, Dong S. Yang
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Patent number: 9527825Abstract: Disclosed is a method of crystallizing docetaxel comprising combining docetaxel and at least one solubilizing solvent to obtain a solution, wherein the solubilizing solvent is methylene chloride and adding an anti-solvent to the solution to obtain a crystalline docetaxel, wherein the anti-solvent is water.Type: GrantFiled: February 25, 2016Date of Patent: December 27, 2016Assignee: Phyton Holdings, LLCInventors: Brian A. Bucher, Edward M. Desimone, III, Roland R. Franke, Rex T. Gallagher, Barry J. Hand, Christopher D. Howe, James H. Johnson, John S. Juchum, Marc A. Plante, T. G. Sambandam, Dong S. Yang
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Publication number: 20160176837Abstract: Disclosed is a method of crystallizing docetaxel comprising combining docetaxel and at least one solubilizing solvent to obtain a solution, wherein the solubilizing solvent is methylene chloride and adding an anti-solvent to the solution to obtain a crystalline docetaxel, wherein the anti-solvent is water.Type: ApplicationFiled: February 25, 2016Publication date: June 23, 2016Inventors: Brian A. Bucher, Edward M. Desimone, III, Roland R. Franke, Rex T. Gallagher, Barry J. Hand, Christopher D. Howe, James H. Johnson, John S. Juchum, Marc A. Plante, T.G. Sambandam, Dong S. Yang
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Patent number: 9303004Abstract: Disclosed is a method of crystallizing a taxane comprising combining the taxane and methylene chloride to obtain a solution and adding an anti-solvent to the solution to obtain a crystalline taxane, wherein the anti-solvent is selected from the group consisting of hexane and heptane.Type: GrantFiled: February 24, 2014Date of Patent: April 5, 2016Assignee: Phyton Holdings, LLCInventors: James H. Johnson, T. G. Sambandam, Barry J. Hand, Christopher D. Howe, Roland R. Franke, Brian A. Bucher, John S. Juchum, Rex T. Gallagher, Marc A. Plante, Edward M. Desimone, III, Dong S. Yang
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Publication number: 20150005517Abstract: Disclosed is a method of crystallizing a taxane comprising combining the taxane and methylene chloride to obtain a solution and adding an anti-solvent to the solution to obtain a crystalline taxane, wherein the anti-solvent is selected from the group consisting of hexane and heptane.Type: ApplicationFiled: February 24, 2014Publication date: January 1, 2015Applicant: Phyton Holdings LLCInventors: James H. Johnson, T.G. Sambandam, Barry J. Hand, Christopher D. Howe, Roland R. Franke, Brian A. Bucher, John S. Juchum, Rex T. Gallagher, Marc A. Plante, Edward M. Desimone, III, Dong S. Yang
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Patent number: 8703982Abstract: Disclosed is a method of crystallizing a taxane comprising combining the taxane and methylene chloride to obtain a solution and adding an anti-solvent to the solution to obtain a crystalline taxane, wherein the anti-solvent is selected from the group consisting of hexane and heptane.Type: GrantFiled: February 12, 2010Date of Patent: April 22, 2014Assignee: Phyton Holdings LLCInventors: Brian A. Bucher, Edward M. Desimone, III, Roland R. Franke, Rex T. Gallagher, Barry J. Hand, Christopher D. Howe, James A. Johnson, John S. Juchum, Marc A. Plante, T. G. Sambandam, Dong S. Yang
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Patent number: 7897796Abstract: This invention is directed to a method for isolating and/or purifying one or more taxanes from materials comprising taxanes. In one embodiment, the method comprises the steps of: (a) treating a taxane containing material with an amino containing material attached to a solid matrix, such as a polyethyleneimine-bonded silica chromatographic resin; (b) eluting the desired taxane compound from the resin; and (c) recovering the eluted taxane compound.Type: GrantFiled: June 18, 2007Date of Patent: March 1, 2011Assignee: Phyton Holdings, LLCInventors: James H. Johnson, T. G. Sambandam, Barry J. Hand, Christopher D. Howe, Roland R. Franke, Brian A. Bucher, John S. Juchum, Rex T. Gallagher, Marc A. Plante, Edward M. Desimone, III, Dong S. Yang
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Publication number: 20100145080Abstract: Disclosed is a method of crystallizing a taxane comprising combining the taxane and methylene chloride to obtain a solution and adding an anti-solvent to the solution to obtain a crystalline taxane, wherein the anti-solvent is selected from the group consisting of hexane and heptane.Type: ApplicationFiled: February 12, 2010Publication date: June 10, 2010Applicant: Phyton Holdings LLCInventors: James H. Johnson, T.G. Sambandam, Barry J. Hand, Christopher D. Howe, Roland R. Franke, Brian A. Bucher, John S. Juchum, Rex T. Gallagher, Marc A. Plante, Edward M. Desimone, III, Dong S. Yang
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Patent number: 6956123Abstract: This invention is directed to a method for isolating and/or purifying one or more taxanes from materials comprising taxanes. In one embodiment, the method comprises the steps of: (a) treating a taxane containing material with an amino containing material attached to a solid matrix, such as a polyethyleneimine-bonded silica chromatographic resin; (b) eluting the desired taxane compound from the resin; and (c) recovering the eluted taxane compound.Type: GrantFiled: September 18, 2003Date of Patent: October 18, 2005Assignee: Natural Pharmaccuticals, Inc.Inventors: James H. Johnson, T. G. Sambandan, Barry J. Haad, Christopher D. Howe, Roland R. Franke, Brian A. Bucher, John S. Juchum, Rex T. Gallagher, Marc A. Plant, Edward M. De Simone, III, Dong S. Yang
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Publication number: 20040186305Abstract: This invention is directed to a method for isolating and/or purifying one or more taxanes from materials comprising taxanes. In one embodiment, the method comprises the steps of: (a) treating a taxane containing material with an amino containing material attached to a solid matrix, such as a polyethyleneimine-bonded silica chromatographic resin; (b) eluting the desired taxane compound from the resin; and (c) recovering the eluted taxane compound.Type: ApplicationFiled: September 18, 2003Publication date: September 23, 2004Inventors: James H. Johnson, T.G. Sambandan, Barry J. Hand, Christopher D. Howe, Roland R. Franke, Brian A. Bucher, John S. Jucham, Rex T. Gallagher, Marc A. Plant, Edward M. De Simone, Dong S. Yang