Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A brake arrangement for a vehicle comprising a braking system arranged to vary hydraulic or pneumatic brake pressure that is arranged to apply a pressure to a brake caliper; an electric motor arranged to generate a braking torque that is applied to a first wheel when the electric motor is placed in a braking mode of operation, wherein the electric motor is arranged to vary brake torque generated when the electric motor is in the braking mode dependent upon a predetermined operating condition of the braking system.

Abstract: A control system for a vehicle having a first wheel (101) arranged to be driven by a first drive source and a second wheel (101) arranged to be driven by a second drive source, wherein the first wheel and the second wheel are transversely located on the vehicle, the control system comprising a controller (102) and a monitoring device, wherein the monitoring device is arranged to monitor the power differential between the power being applied to the first wheel by the first drive source and the power being applied to the second wheel by the second drive source, wherein upon a determination that the power differential between the power being applied to the first wheel and the second wheel is greater than a predetermined value, the controller is arranged to reduce the power differential.

Abstract: A control system for a vehicle having a first wheel (101) arranged to be driven by a first drive source and a second wheel (101) arranged to be driven by a second drive source, wherein the first wheel and the second wheel are transversely located on the vehicle, the control system comprising a controller (102) and a monitoring device, wherein the monitoring device is arranged to monitor the power differential between the power being applied to the first wheel by the first drive source and the power being applied to the second wheel by the second drive source, wherein upon a determination that the power differential between the power being applied to the first wheel and the second wheel is greater than a predetermined value, the controller is arranged to reduce the power differential.

Abstract: A communications system comprises a transmitter, receiver and channel. The transmitter transmits multiple copies of each data bit in a multi-dimension modulation scheme matrix, the dimensions being selected from frequency, time and code. Each dimension is divided into sub-groups. A bit-loading method is used such that copies of each data bit (b11, b12, b13) are allocated within the matrix according to a predetermined arrangement so that within each dimension copies of the same data bit reside within different sub-groups.

Abstract: A suspension control system for a vehicle having a wheel (52) mounted to the vehicle via a suspension device mounted to a mounting point on the vehicle with an electric motor being arranged to apply to the wheel a torque for driving the wheel, the suspension control system comprising a controller arranged to modulate a torque applied to the wheel by the electric motor based on the relative longitudinal movement of the wheel with respect to the mounting point on the vehicle.

Abstract: A communications system comprises a transmitter, receiver and channel. The transmitter transmits multiple copies of each data bit in a multi-dimension modulation scheme matrix, the dimensions being selected from frequency, time and code. Each dimension is divided into sub-groups. A bit-loading method is used such that copies of each data bit (b11, b12, b13) are allocated within the matrix according to a predetermined arrangement so that within each dimension copies of the same data bit reside within different sub-groups.

Abstract: A brake arrangement for a vehicle comprising a braking system arranged to vary hydraulic or pneumatic brake pressure that is arranged to apply a pressure to a brake calliper; an electric motor arranged to generate a braking torque that is applied to a first wheel when the electric motor is placed in a braking mode of operation, wherein the electric motor is arranged to vary brake torque generated when the electric motor is in the braking mode dependent upon a predetermined operating condition of the braking system.

Abstract: A suspension control system for a vehicle having a wheel (52) mounted to the vehicle via a suspension device mounted to a mounting point on the vehicle with an electric motor being arranged to apply to the wheel a torque for driving the wheel, the suspension control system comprising a controller arranged to modulate a torque applied to the wheel by the electric motor based on the relative longitudinal movement of the wheel with respect to the mounting point on the vehicle.

Abstract: Owing to the complexity of integrated circuits, circuit parameters such as component values must be determined to achieve an optimised measure of circuit performance. A method of determining a preferred value of at least one electronic system component, 12, 14, 16, 18, 20, 22, 24, 26 or 28, which optimises one or more characteristics of an electronic system 10. The method comprising: expressing a steady state condition; selecting a trial value for the or each system component and calculating said steady state at the or each point; and applying a perturbation to the value of at least one of the said system components, such that a localised region around said steady state condition is linearised; and determining, as a consequence of said perturbation, a new steady state condition of said electronic system. A computer program carries out the prescribed optimisation method.