Patents by Inventor Christopher Fang-Yen
Christopher Fang-Yen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11795423Abstract: A composition, including a substrate having a planar array of depressions each defined by concave walls and a moat disposed around each depression of said array of depressions.Type: GrantFiled: June 26, 2015Date of Patent: October 24, 2023Assignee: The Trustees of the University of PennsylvaniaInventor: Christopher Fang-Yen
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Publication number: 20210084867Abstract: Systems and methods for automated imaging and manipulation of a plurality of small organisms are provided. In exemplary embodiments, the disclosed subject matter provides a housing, comprising an upper gantry, a lower gantry, and a tray with an array of plates, wherein the tray includes at least one source plate and at least one destination plate. The tray is adapted to hold the plurality of small organisms. A carriage, disposed within the upper gantry, is adapted to move relative to the tray. A camera, also disposed within the carriage, is adapted to acquire images of at least a portion of the small organisms. A computational processor, coupled to the camera, is adapted to identify an approximate size and shape for at least a portion of the small animals from the images, and to select one or more small animals based therefrom on its size and shape.Type: ApplicationFiled: November 16, 2020Publication date: March 25, 2021Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Christopher FANG-YEN, Anthony FOUAD
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Publication number: 20170107470Abstract: A composition, including a substrate having a planar array of depressions each defined by concave walls and a moat disposed around each depression of said array of depressions.Type: ApplicationFiled: June 26, 2015Publication date: April 20, 2017Inventor: Christopher Fang-Yen
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Patent number: 9546952Abstract: The present invention relates to systems and methods for quantitative three-dimensional mapping of refractive index in living or non-living cells, tissues, or organisms using a phase-shifting laser interferometric microscope with variable illumination angle. A preferred embodiment provides tomographic imaging of cells and multicellular organisms, and time-dependent changes in cell structure and the quantitative characterization of specimen-induced aberrations in high-resolution microscopy with multiple applications in tissue light scattering.Type: GrantFiled: September 18, 2014Date of Patent: January 17, 2017Assignee: Massachusetts Institute of TechnologyInventors: Wonshik Choi, Ramachandra Dasari, Christopher Fang-Yen, Michael Feld
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Patent number: 9528817Abstract: Preferred embodiments of the present invention are directed to systems for phase measurement of biological materials which can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. The structure and dynamics of sub-cellular constituents cannot be currently studied in their native state using the existing methods and technologies including, for example, x-ray and neutron scattering.Type: GrantFiled: December 14, 2012Date of Patent: December 27, 2016Assignee: Massachusetts Institute of TechnologyInventors: Christopher Fang-Yen, Gabriel Popescu, Changhuei Yang, Adam Wax, Ramachandra Dasari, Michael Feld
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Patent number: 9433351Abstract: The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively.Type: GrantFiled: May 4, 2012Date of Patent: September 6, 2016Assignee: Massachusetts Institute of TechnologyInventors: Chung-Chieh Yu, Condon Lau, Stephen Fulghum, Christopher Fang-yen, Ramachandra Dasari, Michael Feld, David Feld, Alison Hearn, Jonathan Feld
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Patent number: 8334982Abstract: Preferred embodiments of the present invention are directed to systems for phase measurement which address the problem of phase noise using combinations of a number of strategies including, but not limited to, common-path interferometry, phase referencing, active stabilization and differential measurement. Embodiment are directed to optical devices for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code.Type: GrantFiled: June 30, 2009Date of Patent: December 18, 2012Assignee: Massachusetts Institute of TechnologyInventors: Christopher Fang-Yen, Gabriel Popescu, Changhuei Yang, Adam Wax, Ramachandra Dasari, Michael Feld
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Publication number: 20120259228Abstract: The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively.Type: ApplicationFiled: May 4, 2012Publication date: October 11, 2012Inventors: Chung-Chieh Yu, Condon Lau, Stephen Fulghum, Christopher Fang-yen, Ramachandra Dasari, Michael Feld, David Feld, Alison Hearn, Jonathan Feld
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Publication number: 20070167835Abstract: The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively.Type: ApplicationFiled: July 25, 2006Publication date: July 19, 2007Inventors: Chung-Chieh Yu, Condon Lau, Stephen Fulghum, Christopher Fang-Yen, Ramachandra Dasari, Michael Feld
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Publication number: 20050105097Abstract: Preferred embodiments of the present invention are directed to systems for phase measurement which address the problem of phase noise using combinations of a number of strategies including, but not limited to, common-path interferometry, phase referencing, active stabilization and differential measurement. Embodiment are directed to optical devices for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code.Type: ApplicationFiled: June 18, 2004Publication date: May 19, 2005Applicant: Massachusetts Institute of TechnologyInventors: Christopher Fang-Yen, Gabriel Popescu, Changhuei Yang, Adam Wax, Ramachandra Dasari, Michael Feld
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Publication number: 20050057756Abstract: Preferred embodiments of the present invention are directed to systems for phase measurement which address the problem of phase noise using combinations of a number of strategies including, but not limited to, common-path interferometry, phase referencing, active stabilization and differential measurement. Embodiment are directed to optical devices for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code.Type: ApplicationFiled: April 13, 2004Publication date: March 17, 2005Applicant: Massachusetts Institute of TechnologyInventors: Christopher Fang-Yen, Gabriel Popescu, Changhuei Yang, Adam Wax, Ramachandra Dasari, Michael Feld