Abstract: Methods are provided for acutely treating migraine headache with or without aura. The methods comprise administering to a subject with migraine headache an effective dose of a liquid pharmaceutical composition comprising dihydroergotamine (DHE) or a salt thereof, wherein the dose is administered by an intranasal delivery device that provides, following intranasal administration, (a) a mean peak plasma DHE concentration (Cmax) of at least 750 pg/ml, (b) with a mean time to Cmax (Tmax) of DHE of less than 45 minutes, and (c) a mean plasma AUC0-inf of DHE of at least 2500 pg*hr/ml. Also provided are kits for acutely treating migraine with or without aura in which a liquid pharmaceutical composition comprising DHE or DHE salt is contained within a sealed vial that is attachable to a precision intranasal olfactory delivery device packaged therewith.

Abstract: An apparatus for handling three-dimensionally curved snack food chips. The apparatus includes a first conveyor for conveying a series of the snack food chips on a conveying surface and an inverting station located at an output end of the first conveyor. The inverting station includes an inverter configured for transferring the snack food chips from an output end of the first conveyor into contact with an internal concave surface of the inverter. A drive system for the inverter is configured to move the internal concave surface downwardly to cause movement of the snack food chips downward from an upper portion to a lower portion of the internal concave surface. A depositing station is located and configured for depositing the snack food chips from the lower portion of the internal concave surface onto a second conveyor configured for receiving snack food chips from the depositing station and conveying them away.

Abstract: A delivery device for a compound including: a housing, vial holding a compound; and a source of propellant, wherein the housing provides an inlet and an outlet for the vial, wherein the inlet is in fluid communication with the source of propellant and is directed against the in-line nasal delivery device compound and the outlet allows for delivery of the compound.

Abstract: Techniques are provided for determining a propensity or likelihood that a person in a social network will perform a particular action. A statistical model that is trained based on multiple features of each member in a first plurality of members of a social network is stored. The multiple features include a subset pertaining to profile information provided by the first plurality of members and stored in a plurality of profiles of the first plurality of members. For each member of a second plurality of members of the social network, multiple feature values that correspond to the plurality of features are identified, the statistical model is used to generate a score for the member. The score indicates a likelihood that the member will perform the particular action.

Abstract: A unit dose container for the containment of an intranasal formulation for use with the POD device.

Abstract: A system comprising a payment account generated by the payor and adapted to receive the payment from the payor and transfer the payment to the payee in at least one form of payment, a funding account to provide funds to a fund holding account which is adapted to provide the payment to the payment account, a payment processor to process the payment from the payor to the payment account and process the payment from the payment account to the payee, and a payee portal to be accessed by the payee and receive the payment from the payment account. The payment account is a dedicated account for only the payee, and the payee self-directs the transfer of funds and controls the form of payment made from the payment account. A method further comprising generating a payment account, providing funds to the payment account, and self-directing funds from the payment account.

Abstract: A radar system includes at least one transmit array comprising a plurality of metamaterial elements. The radar system further includes at least one near-field stimulator for inputting electromagnetic signal to the transmit array so that a sub-wavelength target is illuminated with an electromagnetic wave.

Abstract: Techniques are described for wireless energy transmission and projecting magnetic fields over relatively long near-fields. In one example, a device for transmitting near-field energy comprises at least one source that generates a radiofrequency (RF) signal, an antenna that generates near-field signals from the RF signal, and a plurality of sub-wavelength sized elements that form a lens in communication with the antenna that captures the near-field signals, generates near-field energy, and re-directs the near-field energy toward an object in the near-field of the lens, where the sub-wavelength sized elements are disposed about the antenna.

Abstract: A radar system includes at least one transmit array comprising a plurality of metamaterial elements. The radar system further includes at least one near-field stimulator for inputting electromagnetic signal to the transmit array so that a sub-wavelength target is illuminated with an electromagnetic wave.

Abstract: An antenna array includes at least one transmit array comprising a plurality of metamaterial elements. The antenna array further includes at least one near-field stimulator for inputting electromagnetic signal to the transmit array so that a sub-wavelength target is illuminated with an electromagnetic wave.

Abstract: A radar system includes at least one transmit array comprising a plurality of metamaterial elements. The radar system further includes at least one near-field stimulator for inputting electromagnetic signal to the transmit array so that a sub-wavelength target is illuminated with an electromagnetic wave.

Abstract: A medical system includes a body-contacting signal source adapted to transmit an oscillatory signal though a body to a transducer of a device implanted therein. A detector that is coupled to the transducer, upon detection of a response of the transducer to the signal, activates a radio-frequency (RF) telemetry component of the device.

Abstract: An implantable medical device (“IMD”) configured in accordance with an example embodiment of the invention generally includes a housing, a connector header block coupled to the housing, and a telemetry antenna located within the header block. The header block is formed from a dielectric material, which encapsulates the antenna. The antenna is configured to support far field telemetry with an external device such as a programmer. In one example embodiment, the antenna is formed from a thin round wire, has a feed point on the top perimeter sidewall of the housing, and has a floating endpoint in the header block. The antenna is contoured to form a simple curve in a plane that is approximately parallel with the major sides of the housing.

Abstract: An implantable medical device (“IMD”) as described herein is configured to support concurrent multichannel data communication with one or more other devices within a body area network corresponding to a patient. The IMD, and possibly other devices within the body area network, can support the multichannel communication with any number of additional IMDs implanted within the body of the same patient. Moreover, one or more of the concurrent data communication channels may be a full-duplex channel. Example embodiments can be flexibly configured to support different data communication protocols and/or different modulation schemes as needed to suit the particular application or operating environment.

Abstract: A core unit for a heat exchanger comprises a pair of headers spaced from one another each defining a fluid space for receiving a fluid therein and each defining a plurality of apertures. A first region comprising a plurality of first tubes extends between the headers and a first fin is disposed between adjacent pairs of the first tubes. A second region comprising a plurality of second tubes extends between the headers and a second fin is disposed between adjacent pairs of the second tubes. A crushable center different than the first and second regions is disposed parallelly between the first and second regions for controllably crushing when the headers are bent.

Abstract: An implantable medical device (“IMD”) configured in accordance with an example embodiment of the invention generally includes a housing, a connector header block coupled to the housing, a dielectric sheath located around at least a portion of the housing and/or around at least a portion of the header block, and a telemetry antenna located within the dielectric sheath. The antenna is configured to support far field telemetry with an external device such as a programmer. In one example embodiment, the antenna is configured as a balanced antenna having two separate antenna elements driven 180 degrees out of phase. Each of the antenna elements has a feed point on a perimeter edge of the IMD housing and a floating endpoint. A number of alternate embodiments are also provided.

Abstract: An implantable medical device (“IMD”) configured in accordance with an example embodiment of the invention generally includes a housing, a connector header block coupled to the housing, and a telemetry antenna located within the header block. The header block is formed from a dielectric material, which encapsulates the antenna. The antenna is configured to support far field telemetry with an external device such as a programmer. In one example embodiment, the antenna is formed from a thin round wire, has a feed point on the top perimeter sidewall of the housing, and has a floating endpoint in the header block. The antenna is contoured to form a simple curve in a plane that is approximately parallel with the major sides of the housing.

Abstract: The subject invention provides a heat exchanger assembly including a tank having a wall defining an aperture with a fitting secured thereto and a method of securing the fitting thereto. The fitting has a first end with an outer perimeter disposed exteriorly thereof and smaller than the aperture for inserting the first end of the fitting into the aperture. The fitting also has an internal tunnel extending along an axis thereto from the first end. A step of material is disposed in the tunnel at the first end, which is at least in part, radially and longitudinally displaced relative to the axis into contact with the wall to prevent rotational movement of the fitting in the aperture.

Abstract: Vibration or acoustic sound control is achieved using an elastic layer of thermal or insulation material in which a plurality of discrete masses are distributed throughout. The elastic layer may be installed as a pre-formed layer, or be blown into position within a structure where vibration or acoustic sound control is required.

Abstract: A heat exchanger assembly includes a core having first and second header tanks covered by tank caps. A pair of core reinforcing members presenting terminal ends extend between the first and second header tanks. A least one tab and an opening for receiving the tab are used for connecting the core reinforcing members to the tank caps.