Abstract: A syringe comprises a body member detachably secured onto one end of a syringe barrel provided at its other end with a delivery tube and containing a movable piston member; a piston actuating assembly movably mounted in the body member and comprising a tube generally coaxial with the barrel and a rod movably mounted within the tube; and a pawl for moving said piston actuating assembly whereby the tube is first displaced to move the piston to the distal end of the barrel and the rod is then moved to pierce the central region of the piston member and to pass through the piston into the delivery tube.